目的:探究南蛇藤素(Celastrol,Cel)调节高迁移率组框1(high mobility group box 1,HMGB1)-晚期糖基化终产物(receptor for advanced glycation end products,RAGE)信号通路对牙周炎大鼠牙周组织损伤的影响及其机制。方法:建立牙周炎大...目的:探究南蛇藤素(Celastrol,Cel)调节高迁移率组框1(high mobility group box 1,HMGB1)-晚期糖基化终产物(receptor for advanced glycation end products,RAGE)信号通路对牙周炎大鼠牙周组织损伤的影响及其机制。方法:建立牙周炎大鼠模型。将大鼠分为对照组(Control组)、模型组(Model组)、南蛇藤素低、中、高剂量组[Cel-L组,1 mg/(kg·d)Cel,Cel-M组,2 mg/(kg·d)Cel和Cel-H组,4 mg/(kg·d)Cel]和Cel-H+HMGB1重组蛋白[4 mg/(kg·d)Cel-H+R-HMGB1]。评定牙周组织炎症情况;微计算机断层扫描观察牙槽骨吸收情况;苏木精-伊红染色和抗酒石酸酸性磷酸酶染色分别观察牙周组织病理变化和破骨细胞数变化;酶联免疫吸附试验检测白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)和γ-干扰素(interferon-gamma,IFN-γ)超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(Malondialdehyde,MDA)、过氧化氢酶(catalase,CAT)、活性氧(reactive oxygen species,ROS)、一氧化氮(nitric oxide,NO)和前列腺素E2(prostaglandin E2,PGE2)水平;Westernblot检测HMGB1、RAGE蛋白水平。结果:与Control组相比,Model组大鼠牙龈乳头部分缺失和牙龈上皮侵蚀或溃疡,牙龈上皮和固有层发现大量炎性细胞浸润,牙周胶原束排列不规则,部分胶原纤维溶解变性,牙槽骨吸收明显;大鼠牙龈指数、牙龈出血指数、釉牙骨质界到牙槽嵴顶的距离值、牙周组织破骨细胞数、血清IL-6、TNF-α和IFN-γ水平、牙周组织MDA、ROS、NO和PGE2水平及HMGB1和RAGE蛋白表达显著增加(P<0.05),牙周组织SOD和CAT水平显著降低(P<0.05);与Model组相比,Cel-L组、Cel-M组和Cel-H组大鼠牙槽骨损伤和炎症侵蚀减轻,大鼠牙龈指数、牙龈出血指数、CEJ-ABC值、牙周组织破骨细胞数、血清IL-6、TNF-α和IFN-γ水平、牙周组织MDA、ROS、NO和PGE2水平及HMGB1和RAGE蛋白表达显著降低(P<0.05),牙周组织SOD和CAT水平显著增加(P<0.05),且呈剂量依赖性;HMGB1重组蛋白可逆转南蛇藤素对牙周炎大鼠牙周组织损伤的抑制作用(P<0.05)。结论:南蛇藤素通过抑制HMGB1-RAGE信号通路从而抑制牙周炎大鼠牙周组织损伤。展开更多
Building a model for a object through model composition is a interesting topics, this paper research the interface composit ion of models in the Zeigler’s modeling methodology DEVS.
Up to now, the primary method for studying critical porosity and porous media are experimental measurements and data analysis. There are few references on how to numerically calculate porosity at the critical point, p...Up to now, the primary method for studying critical porosity and porous media are experimental measurements and data analysis. There are few references on how to numerically calculate porosity at the critical point, pore fluid-related parameters, or framework-related parameters. So in this article, we provide a method for calculating these elastic parameters and use this method to analyze gas-bearing samples. We first derive three linear equations for numerical calculations. They are the equation of density p versus porosity Ф, density times the square of compressional wave velocity p Vp^2 versus porosity, and density times the square of shear wave velocity pVs^2 versus porosity. Here porosity is viewed as an independent variable and the other parameters are dependent variables. We elaborate on the calculation steps and provide some notes. Then we use our method to analyze gas-bearing sandstone samples. In the calculations, density and P- and S-velocities are input data and we calculate eleven relative parameters for porous fluid, framework, and critical point. In the end, by comparing our results with experiment measurements, we prove the viability of the method.展开更多
This paper focuses on solving a problem of improving system robustness and the efficiency of a distributed system at the same time. Fault tolerance with active replication and load balancing techniques are used. The p...This paper focuses on solving a problem of improving system robustness and the efficiency of a distributed system at the same time. Fault tolerance with active replication and load balancing techniques are used. The pros and cons of both techniques are analyzed, and a novel load balancing framework for fault tolerant systems with active replication is presented. Hierarchical architecture is described in detail. The framework can dynamically adjust fault tolerant groups and their memberships with respect to system loads. Three potential task scheduler group selection methods are proposed and simulation tests are made. Further analysis of test data is done and helpful observations for system design are also pointed out, including effects of task arrival intensity and task set size, relationship between total task execution time and single task execution time.展开更多
It's promising to use Software-Defined Networking(SDN) and Network Functions Virtualization(NFV) to integrate satellite and terrestrial networks. To construct network service function chains in such a multi-domain...It's promising to use Software-Defined Networking(SDN) and Network Functions Virtualization(NFV) to integrate satellite and terrestrial networks. To construct network service function chains in such a multi-domain environment, we propose a horizontal-based Multi-domain Service Function Chaining(Md-SFC) orchestration framework. In this framework, multi-domain orchestrators can coordinate with each other to guarantee the end-to-end service quality. Intra-domain orchestrators also coordinate SDN controllers and NFV management components to implement intra-domain service function chains. Based on this, we further propose a heuristic SFC mapping algorithm with a cooperative inter-domain path calculation method to map service function chains to infrastructures. In this method, master multi-domain orchestrator and intra-domain orchestrators coordinate to select proper inter-domain links. We compare the cooperative method with a naive uncooperative way that domains' topology information is provided to the master multi-domain orchestrator and it calculates the shortest inter-domain path between intra-domain service function chains directly. Simulation results demonstrate that our solution is feasible. It is able to construct end-to-end performance guaranteed service function chain by horizontal-based cooperation. The cooperative inter-domain path calculation method decreasesthe mapping load for the master orchestrator and gets the same end-to-end performance.展开更多
The axial charges of the proton and N（1440） are studied in the framework of an extended constituent quark model （CQM） including qqqqq components. The cancellation between the contributions of qqq components and qq...The axial charges of the proton and N（1440） are studied in the framework of an extended constituent quark model （CQM） including qqqqq components. The cancellation between the contributions of qqq components and qqqqq components gives a natural explanation to the experimental value of the proton axial charge, which can not be well reproduced in the traditional CQM even after the SU（6） × O（3） symmetry breaking is taken into account. The experimental value of axial charge pins down the proportion of the qqqqq component in the proton to about 20%, which is consistent with the ones given by the strong decay widths and helicity amplitudes. Besides, an axial charge for N（1440） about 1 is predicted with 30% qqqqq component, which is obtained by the strong and electromagnetic decays.展开更多
This study addresses current status of ESSQ management and integration in steel production organisation. The idea is to benchmark maturity levels with the leading Finnish international companies. The examination has b...This study addresses current status of ESSQ management and integration in steel production organisation. The idea is to benchmark maturity levels with the leading Finnish international companies. The examination has been done in compliance with applied maturity model developed by the target corporation. When examining the benchmarked companies through the ESSQ framework, we found that a similar framework cannot be found in any other company as such; instead, operations are distributed under different organisations. Although many sources criticise system-based development, the results of this study indicate that it is nevertheless an efficient way to develop operations.展开更多
文摘Building a model for a object through model composition is a interesting topics, this paper research the interface composit ion of models in the Zeigler’s modeling methodology DEVS.
基金supported by the National Natural Science Foundation of China (Grant No.40874052)the Key Laboratory of Geo-detection (China University of Geosciences,Beijing),Ministry of Education
文摘Up to now, the primary method for studying critical porosity and porous media are experimental measurements and data analysis. There are few references on how to numerically calculate porosity at the critical point, pore fluid-related parameters, or framework-related parameters. So in this article, we provide a method for calculating these elastic parameters and use this method to analyze gas-bearing samples. We first derive three linear equations for numerical calculations. They are the equation of density p versus porosity Ф, density times the square of compressional wave velocity p Vp^2 versus porosity, and density times the square of shear wave velocity pVs^2 versus porosity. Here porosity is viewed as an independent variable and the other parameters are dependent variables. We elaborate on the calculation steps and provide some notes. Then we use our method to analyze gas-bearing sandstone samples. In the calculations, density and P- and S-velocities are input data and we calculate eleven relative parameters for porous fluid, framework, and critical point. In the end, by comparing our results with experiment measurements, we prove the viability of the method.
文摘This paper focuses on solving a problem of improving system robustness and the efficiency of a distributed system at the same time. Fault tolerance with active replication and load balancing techniques are used. The pros and cons of both techniques are analyzed, and a novel load balancing framework for fault tolerant systems with active replication is presented. Hierarchical architecture is described in detail. The framework can dynamically adjust fault tolerant groups and their memberships with respect to system loads. Three potential task scheduler group selection methods are proposed and simulation tests are made. Further analysis of test data is done and helpful observations for system design are also pointed out, including effects of task arrival intensity and task set size, relationship between total task execution time and single task execution time.
基金supported by National High Technology of China ("863 program") under Grant No. 2015AA015702NSAF under Grant No.U1530118+1 种基金NSFC under Grant No.61602030National Basic Research Program of China ("973 program")under Grant No. 2013CB329101
文摘It's promising to use Software-Defined Networking(SDN) and Network Functions Virtualization(NFV) to integrate satellite and terrestrial networks. To construct network service function chains in such a multi-domain environment, we propose a horizontal-based Multi-domain Service Function Chaining(Md-SFC) orchestration framework. In this framework, multi-domain orchestrators can coordinate with each other to guarantee the end-to-end service quality. Intra-domain orchestrators also coordinate SDN controllers and NFV management components to implement intra-domain service function chains. Based on this, we further propose a heuristic SFC mapping algorithm with a cooperative inter-domain path calculation method to map service function chains to infrastructures. In this method, master multi-domain orchestrator and intra-domain orchestrators coordinate to select proper inter-domain links. We compare the cooperative method with a naive uncooperative way that domains' topology information is provided to the master multi-domain orchestrator and it calculates the shortest inter-domain path between intra-domain service function chains directly. Simulation results demonstrate that our solution is feasible. It is able to construct end-to-end performance guaranteed service function chain by horizontal-based cooperation. The cooperative inter-domain path calculation method decreasesthe mapping load for the master orchestrator and gets the same end-to-end performance.
基金Support by National Natural Science Foundation of China under Grant No.10905077
文摘The axial charges of the proton and N（1440） are studied in the framework of an extended constituent quark model （CQM） including qqqqq components. The cancellation between the contributions of qqq components and qqqqq components gives a natural explanation to the experimental value of the proton axial charge, which can not be well reproduced in the traditional CQM even after the SU（6） × O（3） symmetry breaking is taken into account. The experimental value of axial charge pins down the proportion of the qqqqq component in the proton to about 20%, which is consistent with the ones given by the strong decay widths and helicity amplitudes. Besides, an axial charge for N（1440） about 1 is predicted with 30% qqqqq component, which is obtained by the strong and electromagnetic decays.
文摘This study addresses current status of ESSQ management and integration in steel production organisation. The idea is to benchmark maturity levels with the leading Finnish international companies. The examination has been done in compliance with applied maturity model developed by the target corporation. When examining the benchmarked companies through the ESSQ framework, we found that a similar framework cannot be found in any other company as such; instead, operations are distributed under different organisations. Although many sources criticise system-based development, the results of this study indicate that it is nevertheless an efficient way to develop operations.
