自动化物流系统组盘模式分析

本文针对烟草行业自动化物流系统的物料组盘模式进行分析,结合烟草行业各类物流系统及各种物流场景,归纳总结出相应的物料组盘策略。各种组盘策略均以满足工艺设计、可配置性及用户需求为主,同时兼顾系统的可扩展性。

超声振动对风扇盘组叶片装配压装力的影响

为研究超声振动对风扇盘组叶片装配压装力的影响,提出一种将超声振动与压装进行结合的装配方法。并利用控制变量法研究压装形式、压装位移、压装速度、振动幅值4个因素对风扇盘组相邻叶片装配压装力的影响规律。研究表明,叠加超声振动能够有效减小风扇盘组相邻叶片装配的压装力;压装位移越大,装配所需压装力越大,叠加一定振动幅值的超声振动能有效缩小不同压装位移之间的压装力差距;无论是否叠加超声振动,在一定的压装速度范围内,压装速度基本不会对压装力产生影响;在一定振动幅值范围内,随着叠加振动幅值的增加其减小压装力的效果越好,到达某一振动幅值,减小压装力的效果达到最好,可以使压装力减小75%,超过该振动幅值,减小压装力的效果趋于稳定甚至会减弱。

用盘铣刀组展成切齿的方法

<正> 图1所示为苏联研制的用盘形铣刀组展成切齿的一种新方法。它可在普通的滚齿机上进行加工而无需添加其他专用部件或装置。

MNS抽屉式开关柜在罗田泵站中的应用及设计

MNS抽屉式开关柜具有设计紧凑、组装灵活、更替方便等优点,在低压供配电系统中起着重要作用。为了提高低压供配电设计效率,采用将负荷分类和划分盘柜区域的方法,形成了8种组盘策略。该研究成果应用于珠江三角洲水资源配置工程罗田泵站低压站用电设计,可为同类型水利工程的厂(站)用电设计提供借鉴。

Mesenchymal stem cells derived from human placenta suppress allogeneic umbilical cord blood lymphocyte proliferation

Human placenta-derived mononuclear cells （MNC） were isolated by a Percoll density gradient and cultured in mesenchymal stem cell （MSC） maintenance medium. The homogenous layer of adherent cells exhibited a typical fibroblastlike morphology, a large expansive potential, and cell cycle characteristics including a subset of quiescent cells. In vitro differentiation assays showed the tripotential differentiation capacity of these cells toward adipogenic, osteogenic and chondrogenic lineages. Flow cytometry analyses and immunocytochemistry stain showed that placental MSC was a homogeneous cell population devoid of hematopoietic cells, which uniformly expressed CD29, CD44, CD73, CD105, CD166, laminin, fibronectin and vimentin while being negative for expression of CD31, CD34, CD45 and m-smooth muscle actin. Most importantly, immuno-phenotypic analyses demonstrated that these cells expressed class Ⅰ major histocompatibility complex （MHC-I）, but they did not express MHC-Ⅱ molecules. Additionally these cells could suppress umbilical cord blood （UCB） lymphocytes proliferation induced by cellular or nonspecific mitogenic stimuli. This strongly implies that they may have potential application in allograft transplantation. Since placenta and UCB are homogeneous, the MSC derived from human placenta can be transplanted combined with hematopoietic stem cells （HSC） from UCB to reduce the potential graft-versus-host disease （GVHD） in recipients.

Dynamic probabilistic analysis of stress and deformation for bladed disk assemblies of aeroengine

In order to describe and control the stress distribution and total deformation of bladed disk assemblies used in the aeroengine, a highly efficient and precise method of probabilistic analysis which is called extremum response surface method(ERSM) is produced based on the previous deterministic analysis results with the finite element model(FEM). In this work, many key nonlinear factors, such as the dynamic feature of the temperature load, the centrifugal force and the boundary conditions, are taken into consideration for the model. The changing patterns with time of bladed disk assemblies about stress distribution and total deformation are obtained during the deterministic analysis, and at the same time, the largest deformation and stress nodes of bladed disk assemblies are found and taken as input target of probabilistic analysis in a scientific and reasonable way. Not only their reliability, historical sample, extreme response surface(ERS) and the cumulative probability distribution function but also their sensitivity and effect probability are obtained. Main factors affecting stress distribution and total deformation of bladed disk assemblies are investigated through the sensitivity analysis of the model. Finally, compared with the response surface method(RSM) and the Monte Carlo simulation(MCS), the results show that this new approach is effective.

Placental expressions of estrogen receptor α,estrogen receptor β in intrahepatic cholestasis of pregnancy

To investigate the association of the expression of estrogen receptor ct, estrogen receptor 13 in placenta with intrahepatic cholestasis of pregnancy （ICP） susceptibility. Methods： In 14 cases of mild ICP, 14 cases of severe ICP and 14 cases of normal cases （control group） with corresponding age and gestation weeks, the expressions of ERa and ERD were detected by means of immunohistochemical method S-P. Results： The mean grey numbers of ERa in each group mentioned above were 151.684±3.76, 149.854±3.69, 153.184±3.18, without significant difference （P〉0.05） The mean grey numbers of ERβ in each group mentioned above were 146.51±3.81, 139.434±9.97, 149.87±4.17, with significant difference （P〉0.05）; the expression of ERI3 of severe ICP group was significantly higher than that of the mild ICP group and the control group （P〈0.05）. The expression of ERβ in every group was higher than that of ERa （P〈0.05）. Conclusion： ERβ maybe play an important part in the etiology and development of ICP

Altered expression of adipose differentiation-related protein gene in placental tissue of pre-eclampsia

Objective: To investigate the altered expression of lipid metabolism-related gene adipose differentiation-related protein (ADRP) in pre-eclampsia. Methods: Semi-quantitative RT-PCR and Western blotting were used to validate the altered expression of ADRP gene between pre-eclamptic placentas (pre-eclampsia group) and normotensive placentas (control group) respectively. In situ hybridization (ISH) was used to localize ADRP mRNA in pre-eclamptic placentas. Results: There was a significant difference in the levels of placental ADRP mRNA between pre-eclampsia group and control group (1. 98±0. 50 vs 1. 09±0. 20, P<0. 01). Western blotting showed that placentas both in pre-eclampsia group and control group expressed the special ADRP band at 48. 1 kD. The relative levels of ADRP protein in pre-eclampsia group were significantly higher than those of control group (0. 40 ±0. 19 vs 0. 19 ±0. 09, P<0. 01 ). ADRP mRNA was diffusely distributed in pre-eclamptic placentas. Their positive staining existed in cytoplasm of trophoblast. Conclusion: Abnormal expression of ADRP gene in pre-eclamptic placenta may be associated with the pathogenesis of pre-eclampsia.

Increased apoptosis in third - trimester placental tissue from gestations complicat-ed by PIH

Objective: To investigate a possible role of apoptosis in the pathophysiologic mechanisms of PIH (pregnancy-induced hypertension syndrome).Methods: In this study, placental samples were obtained from 16 uncomplicated third-trimester pregnancies and from 16 cases of PIH.We used light microscopy, electron microscopy to identify apoptosis.Light microscopy was used to quantify their incidence of apoptosis.Electron microscopy was used to confirm the occurrence of apoptosis.Results: Apoptosis has been conclusively demonstrated within human third-trimester placental tissue.Medians and interquartile ranges of normal placenta (n=16) was 0.12% (0.08%-0.19%); Medians and interquartile ranges of PIH group (n=16) was 0.37% (0.15%-0.49%).Compared to normal placentas, the incidence of apoptosis was higher in placentas from gestations complicated by PIH (P<0.05, T'-test).Conclusion: Placental apoptosis increases significantly in PIH, and it may play a role in the pathophysiologic mechanisms of this syndrome.

Linear Combination of Derivative Weighted Composition Operators

The relation between composition operators on the Dirichlet spaces in the open unit disk and derivative weighted composition operators on the Bergman spaces in the open unit disk is investigated firstly,and for a combination of several derivative weighted composition operators which acts on classic Bergman space,the lower bound of its essential norm is estimated in terms of the boundary data of the symbols of d-composition operators.Some similar results about composition operators on the Dirichlet space are also presented.A necessary condition is given to determine the compactness of the combination of several derivative weighted composition operators on Bergman spaces.

Contribution of placental leptin to the serum levels in preeclampsia and the effect of hypoxia on synthesis of placental leptin

Objective: To investigate the contribution of placental leptin to the serum levels in preeclampsia and the effect of hypoxia on synthesis of placental leptin. Methods: Fifteen preeclamptic women and 20 normotensive pregnant women were recruited in present study. Leptin concentrations in peripheral venous blood samples and uterine venous blood samples were measured by radioimmunoassay. Eight cases of normal human term placental villi were cultured either in normaxia （21%O2） or in hypoxia （2%O2） followed by determining leptin in the culture medium by radioimmunoassay. Results: Leptin concentrations were significantly higher in preeclamptic women than in normotensive pregnant women, both in the peripheral vein （[23.29±12.87] μg/L vs [13.87±5.57] μg/L, P<0.01） and uterine vein （[16.44±8.62] μg/L vs [11.21±4.20] μg/L, P<0.05）. Leptin concentrations were significantly higher in the peripheral vein than in uterine vein, both in the preeclamptic （P<0.01） and in normotensive pregnant women （P<0.01）. Concentrations of leptin in the culture medium were significantly increased in hypoxia than in normoxia （P<0.05）. Conclusion: The pathogenesis of preeclampsia may be associated with an increase of maternal serum leptin and placenta leptin, and hypoxia in placenta may be an important factor that results in preeclamptic placenta to produce more leptin. Placenta is not the principal source of the serum leptin in the preeclamptic women or normotensive pregnant women.

Metallurgical behavior and variation of vibro-acoustic signal during preheating assisted friction stir welding between AA6061-T6 and AA7075-T651 alloys

The present work investigated the effects of pin profiles(cylindrical and square),pin eccentricity(0.5 mm and 1 mm)in cylindrical tool and preheating(secondary heating)on metallurgical behavior,variation of vibro-acoustic signal pattern and joint strength during friction stir welding(FSW)between AA6061-T6 and AA7075-T651 alloys.The eccentric tool pins were observed to provide good flowability and intermixing between dissimilar metals,increased the size of stir zone,and the grains in stir zone were sufficiently finer with eccentric tool pin than concentric pin.The magnitude of vibro-acoustic signal increased when shoulder plunging started and drop in signal was noted when the tool shoulder reached its desired depth.The signal magnitude was noted to be higher in welding stage compared to tool plunging stage as the tool took in fresh material during tool movement along the weld path.Preheating the workpiece prior to pin plunging and during welding notably influenced the flow behavior and mixing pattern,and the grains in stir zone were slightly coarser than those in specimen without preheating.Significant reduction in the magnitude of the signal was also observed after preheating.Tensile and flexural strength of joints were also improved slightly when additional heating was employed.

Effect of Dietary Lipid on the Growth, Fatty Acid Composition and Δ5 Fads Expression of Abalone(Haliotis discus hannai Ino) Hepatopancreas

This study investigated the effect of dietary lipid on the growth, fatty acid composition and Δ5 fatty acyl desaturase genes(Fads) expression of juvenile abalone(Haliotis discus hannai Ino) hepatopancreas. Six purified diets were formulated to contain tripalmitin(TP), olive oil(OO, 72.87% 18:1n-9), grape seed oil(GO, 68.67% 18:2n-6), linseed oil(LO, 70.48% 18:3n-3), ARA oil(AO, 41.81% ARA) or EPA oil(EO, 44.09% EPA and 23.67% DAH). No significant difference in survival rate was observed among abalone fed with different diets. Weight gain rate(WGR) and daily growth rate of shell length(DGRSL) were significantly increased in abalone fed with diets containing OO, AO and EO, but decreased in abalone fed with LO diet(P < 0.05) in comparison with those fed with TP. High level of dietary 18:2n-6 resulted in higher content of n-6 polyunsaturated fatty acids(PUFAs) in abalone fed with GO than those fed with TP, OO, LO and EO(P < 0.05). n-3 PUFAs in abalone fed with LO was significantly higher than those in abalone fed with TP, OO, GO and AO(P < 0.05). The highest contents of 20:1n-9 and 22:1n-9 were observed in abalone fed with OO. The expression of Δ5 Fads in hepatopancreas of abalone was enhanced by high concentration of 18:3n-3 and suppressed by dietary LC-PUFAs; however it was not affected by dietary high concentration of 18:1n-9 or 18:2n-6. These results provided valuable information for understanding the synthesis of LC-PUFAs and nutritional regulation of Δ5 Fads expression in abalone.

智能工厂柔性物流方案与实践

研究某公司在智慧产业城智能工厂柔性物流方案及实践效果,分析了工程机械行业的特点,介绍了某公司智慧产业城智能工厂实施的柔性物流整体解决方案,包括按需供货、柔性配盘、智能分拣、三级联动等。实践证明上述解决方案能够有效提升物流效率、降低成本、提高整体生产效能,为工程机械制造企业在智慧工厂建设中提供了有益的经验和指导意义。

Rotating magnetic field-controlled fabrication of magnetic hydrogel with spatially disk-like microstructures

Composite biomaterials with controllable mi- crostructures play an increasingly important role in tissue engineering and regenerative medicine. Here, we report a magnetic hydrogel composite with disk-like microstructure fabricated by assembly of iron oxide nanopartides during the gelation process in the presence of rotating magnetic field. It should be mentioned that the iron oxide nanoparticles here were synthesized identically following techniques of Fer- umoxytol that is the only inorganic nanodrug approved by FDA for clinical applications. The microstructure of nano- particles inside the hydrogel was ordered three-dimensionally due to the twist of the aligned chains of magnetic nano- particles which leads to the lowest state of systematic energy. The size of microstructure can be tuned from several micro- meters to tens of micrometers by changing the assembly parameters. With the increase of microstructure size, the magnetothermal anisotropy was also augmented. This result confirmed that the assembly-induced anisotropy can occur even for the several micron aggregates of nanopartides. The rotating magnetic field-assisted technique is cost-effective, simple and flexible for the fabrication of composite hydrogel with ordered microstructure. We believe it will be favorable for the quick, green and intelligent fabrication of some com- posite materials.

Gene expression profile of degenerated cervical intervertebral disc tissues in rats

Objective: To analyze the gene expression profile of degenerated cervical intervertebral disc of Sprague Dawley rats on a large scale.Methods: Degenerated models of Sprague Dawley rats of 9 months old (degeneration group, n=9) and normal Sprague Dawley rats of 3 months old (control group, n=9) were prepared, respectively. mRNA was obtained from the cervical intervertebral disc of rats in both groups, respectively, and then labelled by Cy5 and Cy3 fluorescence respectively after reverse transcription to obtain intervertebral disc cDNA probes. cDNA probes were hybridized with BiostarR-40s gene expression profile chips and scanned by laser scanner. The results were treated with portrait analysis, standardization management, and ratio analysis with softwares.Results: Compared with the rats in the control group, (9.6)% (381 pieces in total) gene expression changed obviously in the rats in the degeneration group, among which, the gene expression quantities of 171 pieces increased significantly (r=the ratio of the degeneration group to the control group >(2.0)), 52 pieces of which had certain function. While the gene expression quantities of 211 pieces decreased significantly (r<(0.5)), 41 pieces of which had certain function.Conclusions: Gene chip technology can be used to analyze the gene expression profile of degenerated intervertebral disc of rats in parallel, in quantity and on a large scale, which helps to testify the representative genes and protein expression, and plays an important role in clarifying the pathogenesis of degenerated intervertebral disc.

Electro-acupuncture on the iNOS of Lumbar lntervertebral Disk Tissues in Rats

Objective： The present study is to investigate the mechanism of dectrtyacupuncture in preventing and treating lumbar intervertebral disk displacement. Methods： Seventy-five Sprauge-Dawley rats were used to establish the models of lumbar intervertebral disk displacement by operation, and divided into five groups including electro-acupuncture group, western medicine group, acupuncture plus medicine group, model group and normal control group, then they were treated with corresponding therapeutic method. The expression of inducible nitric oxide synthase （iNOS） mRNA in the lumbar intervertebral disk tissues of rats was detected by RTPCR. Results： The expression of iNOS mRNA in the lumbar intervertebral disk tissues of rats in model group was compared with that in normal control group, the significant difference was found （P〈 0.01）; While the expressions of iNOS mRNA in the lumbar intervertebral disk tissues of rats in electroacupuncture group, western drug group and acupuncture plus medicine group were all inhibited, and compared with the model group, the significant differences were also found （P 〈 0.01）. Conclusion： Electro-acupuncture could inhibit the expression of iNOS mRNA in the lumbar intervertebral disk tissue.