The authors investigate the comparative classification performance of the two groups linear classification techniques. They compared the Fisher linear classification analysis, its robust version based on the minimum c...The authors investigate the comparative classification performance of the two groups linear classification techniques. They compared the Fisher linear classification analysis, its robust version based on the minimum covariance determinant with the Filter linear classification rule and the linear combination linear classification technique. These procedures are investigated using laboratory reared aedes albopictus mosquito data set and simulated data set generated based on heteroscedastic covariance matrices with various proportion of contamination. The evaluation procedure is based on the effect of contamination on the mean probabilities of correct classification obtain for each technique. The comparative analysis revealed that the robust Fisher linear classification rule and the linear combination linear classification rule are robust and comparable than the other procedures.展开更多
Research has shown that the hypomagnetic field(HMF)can affect embryo development,cell proliferation,learning and memory,and in vitro tubulin assembly.In the present study,we aimed to elucidate the molecular mechanism ...Research has shown that the hypomagnetic field(HMF)can affect embryo development,cell proliferation,learning and memory,and in vitro tubulin assembly.In the present study,we aimed to elucidate the molecular mechanism by which the HMF exerts its effect,by comparing the transcriptome profiles of human neuroblastoma cells exposed to either the HMF or the geomagnetic field.A total of 2464 differentially expressed genes(DEGs)were identified,216 of which were up-regulated and2248 of which were down-regulated after exposure to the HMF.These DEGs were found to be significantly clustered into several key processes,namely macromolecule localization,protein transport,RNA processing,and brain function.Seventeen DEGs were verified by real-time quantitative PCR,and the expression levels of nine of these DEGs were measured every 6 h.Most notably,MAPK1 and CRY2,showed significant up-and down-regulation,respectively,during the first 6 h of HMF exposure,which suggests involvement of the MAPK pathway and cryptochrome in the early bio-HMF response.Our results provide insights into the molecular mechanisms underlying the observed biological effects of the HMF.展开更多
文摘The authors investigate the comparative classification performance of the two groups linear classification techniques. They compared the Fisher linear classification analysis, its robust version based on the minimum covariance determinant with the Filter linear classification rule and the linear combination linear classification technique. These procedures are investigated using laboratory reared aedes albopictus mosquito data set and simulated data set generated based on heteroscedastic covariance matrices with various proportion of contamination. The evaluation procedure is based on the effect of contamination on the mean probabilities of correct classification obtain for each technique. The comparative analysis revealed that the robust Fisher linear classification rule and the linear combination linear classification rule are robust and comparable than the other procedures.
基金supported by the Queensland-Chinese Academy of Sciences(QCAS)Biotechnology Fund(GJHZ1131)the Project of Chinese Academy of Sciences for the Development of Major Scientific Research Equipment(YZ201148)+1 种基金the National Natural Science Foundation of China(31200628)the External Cooperation Program of Bureau of International Cooperation,Chinese Academy of Sciences(GJHZ201302)
文摘Research has shown that the hypomagnetic field(HMF)can affect embryo development,cell proliferation,learning and memory,and in vitro tubulin assembly.In the present study,we aimed to elucidate the molecular mechanism by which the HMF exerts its effect,by comparing the transcriptome profiles of human neuroblastoma cells exposed to either the HMF or the geomagnetic field.A total of 2464 differentially expressed genes(DEGs)were identified,216 of which were up-regulated and2248 of which were down-regulated after exposure to the HMF.These DEGs were found to be significantly clustered into several key processes,namely macromolecule localization,protein transport,RNA processing,and brain function.Seventeen DEGs were verified by real-time quantitative PCR,and the expression levels of nine of these DEGs were measured every 6 h.Most notably,MAPK1 and CRY2,showed significant up-and down-regulation,respectively,during the first 6 h of HMF exposure,which suggests involvement of the MAPK pathway and cryptochrome in the early bio-HMF response.Our results provide insights into the molecular mechanisms underlying the observed biological effects of the HMF.
