Objective:Vitamin D receptor(VDR)mediates vitamin D activity.We examined whether VDR expression in excised melanoma tissues is associated with VDR gene(VDR)polymorphisms.Methods:We evaluated VDR protein expression(by ...Objective:Vitamin D receptor(VDR)mediates vitamin D activity.We examined whether VDR expression in excised melanoma tissues is associated with VDR gene(VDR)polymorphisms.Methods:We evaluated VDR protein expression(by monoclonal antibody immunostaining),melanoma characteristics,and carriage of VDR-Fok I-rs2228570(C>T),VDR-Bsm I-rs1544410(G>A),VDR-ApaI-rs7975232(T>G),and VDR-TaqI-rs731236(T>C)polymorphisms(by restriction fragment length polymorphism).Absence or presence of restriction site was denoted by a capital or lower letter,respectively:"F"and"f"for Fok I,"B"and"b"for Bsm I,"A"and"a"for ApaI,and "T"and"t"for TaqI endonuclease.Seventy-four Italian cutaneous primary melanomas(52.1±12.7 years old)were studied;51.4% were stage Ⅰ,21.6% stage Ⅱ ,13.5% stage Ⅲ,and 13.5% stage Ⅳ melanomas.VDR expression was categorized as follows:100% positive vs.<100%;over the median 20%(high VDR expression)vs.≤20%(low VDR expression);absence vs.presence of VDR-expressing cells.Results:Stage I melanomas,Breslow thickness of<1.00 mm,level II Clark invasion,Aa heterozygous genotype,and AaTT combined genotype were more frequent in melanomas with high vs.low VDR expression.Combined genotypes BbAA,bbAa,AATt,BbAATt,and bbAaTT were more frequent in 100%vs.<100%VDR-expressing cells.Combined genotype AATT was more frequent in melanomas lacking VDR expression(odds ratio=14.5;P=0.025).VDR expression was not associated with metastasis,ulceration,mitosis>1,regression,tumor-infiltrating lymphocytes,tumoral infiltration of vascular tissues,additional skin and non-skin cancers,and melanoma familiarity.Conclusions:We highlighted that VDR polymorphisms can affect VDR expression in excised melanoma cells.Low VDR expression in AATT carriers is a new finding that merits further study.VDR expression possibly poses implications for vitamin D supplementation against melanoma.VDR expression and VDR genotype may become precise medicinal tools for melanoma in the future.展开更多
The network of political participation is relative to the traditional political participation, it takes the Internet as a carrier, with distinctive character, with a more convenient, fast, and even without time and sp...The network of political participation is relative to the traditional political participation, it takes the Internet as a carrier, with distinctive character, with a more convenient, fast, and even without time and space constraints advantage. Political participation has to be affected by the social and economic development, political system, social and environmental factors, countries generally believe that collaboration between the Government and social organizations, networks of enterprises, schools and other interested parties are currently the main mode of network governance. College students are the main power of the network of political participation, the university plays an important role in the political participation process. Therefore, this article takes online political participation of college students as a starting point, through questionnaires and case interviews and other methods to investigate the current status of college students online political participation, analyze network characteristics and problems of college students in political participation, to guide the college network path which provides reference for orderly participation in political studies.展开更多
This paper explores the value creation of business process management （BPM） and managerial accounting system （MAS） using a case study. The findings show that BPM shortens the management chain and increases the con...This paper explores the value creation of business process management （BPM） and managerial accounting system （MAS） using a case study. The findings show that BPM shortens the management chain and increases the connections among functions in the organization by right reassignment. Accounting indicators in MAS provide necessary information about business processes, which assists performance evaluation in BPM, and meanwhile, incentive schemes give enough motives, which guide employees to take actions in accordance with the organizational strategies and processes＇ goals. The information effect and motive effect of MAS increase employees＇ work satisfaction and their cooperation with each other. In the end, the integration of BPM and MAS improves the organizational economic performance, thus creating value for the organization. The results explain the reason why so much BPM fails in practice, because right assignment, performance evaluation system, and incentive schemes constitute organizational architecture, which is critical to organizational value. Additionally, the value creation of BPM and MAS depends on their coordination with the external environment, the internal situation, and the organizational strategy. From the view of managerial accounting perspective, MAS not only changes with the organization development but also facilitates the organization development.展开更多
Low-carbon advanced nanostructured steels have been developed for various structural engineering applications, including bridges, automobiles, and other strength-critical applications such as the reactor pressure vess...Low-carbon advanced nanostructured steels have been developed for various structural engineering applications, including bridges, automobiles, and other strength-critical applications such as the reactor pressure vessels in nuclear power stations. The mechanical performances and applications of these steels are strongly dependent on their microstructural features. By controlling the size,number density, distribution, and types of precipitates, it is possible to produce nanostructured steels with a tensile strength reaching as high as 2 GPa while keeping a decent tensile elongation above 10% and a reduction of area as high as 40%. Besides, through a careful control of strength contributions from multiple strengthening mechanisms, the nanostructured steels with superior strengths and low-temperature impact toughness can be obtained by avoiding the temper embrittlement regime. With appropriate Mn additions, these nanostructured steels can achieve a triple enhancement in ductility(total tensile elongation, TE of ~30%) at no expense of strengths(yield strength, YS of ~1100 to 1300 MPa, ultimate tensile strength, UTS of ~1300 to 1400 MPa). More importantly, these steels demonstrate good fabricability and weldability. In this paper, the microstructure-property relationships of these advanced nanostructured steels are comprehensively reviewed. In addition, the current limitations and future development of these nanostructured steels are carefully discussed and outlined.展开更多
文摘Objective:Vitamin D receptor(VDR)mediates vitamin D activity.We examined whether VDR expression in excised melanoma tissues is associated with VDR gene(VDR)polymorphisms.Methods:We evaluated VDR protein expression(by monoclonal antibody immunostaining),melanoma characteristics,and carriage of VDR-Fok I-rs2228570(C>T),VDR-Bsm I-rs1544410(G>A),VDR-ApaI-rs7975232(T>G),and VDR-TaqI-rs731236(T>C)polymorphisms(by restriction fragment length polymorphism).Absence or presence of restriction site was denoted by a capital or lower letter,respectively:"F"and"f"for Fok I,"B"and"b"for Bsm I,"A"and"a"for ApaI,and "T"and"t"for TaqI endonuclease.Seventy-four Italian cutaneous primary melanomas(52.1±12.7 years old)were studied;51.4% were stage Ⅰ,21.6% stage Ⅱ ,13.5% stage Ⅲ,and 13.5% stage Ⅳ melanomas.VDR expression was categorized as follows:100% positive vs.<100%;over the median 20%(high VDR expression)vs.≤20%(low VDR expression);absence vs.presence of VDR-expressing cells.Results:Stage I melanomas,Breslow thickness of<1.00 mm,level II Clark invasion,Aa heterozygous genotype,and AaTT combined genotype were more frequent in melanomas with high vs.low VDR expression.Combined genotypes BbAA,bbAa,AATt,BbAATt,and bbAaTT were more frequent in 100%vs.<100%VDR-expressing cells.Combined genotype AATT was more frequent in melanomas lacking VDR expression(odds ratio=14.5;P=0.025).VDR expression was not associated with metastasis,ulceration,mitosis>1,regression,tumor-infiltrating lymphocytes,tumoral infiltration of vascular tissues,additional skin and non-skin cancers,and melanoma familiarity.Conclusions:We highlighted that VDR polymorphisms can affect VDR expression in excised melanoma cells.Low VDR expression in AATT carriers is a new finding that merits further study.VDR expression possibly poses implications for vitamin D supplementation against melanoma.VDR expression and VDR genotype may become precise medicinal tools for melanoma in the future.
文摘The network of political participation is relative to the traditional political participation, it takes the Internet as a carrier, with distinctive character, with a more convenient, fast, and even without time and space constraints advantage. Political participation has to be affected by the social and economic development, political system, social and environmental factors, countries generally believe that collaboration between the Government and social organizations, networks of enterprises, schools and other interested parties are currently the main mode of network governance. College students are the main power of the network of political participation, the university plays an important role in the political participation process. Therefore, this article takes online political participation of college students as a starting point, through questionnaires and case interviews and other methods to investigate the current status of college students online political participation, analyze network characteristics and problems of college students in political participation, to guide the college network path which provides reference for orderly participation in political studies.
文摘This paper explores the value creation of business process management （BPM） and managerial accounting system （MAS） using a case study. The findings show that BPM shortens the management chain and increases the connections among functions in the organization by right reassignment. Accounting indicators in MAS provide necessary information about business processes, which assists performance evaluation in BPM, and meanwhile, incentive schemes give enough motives, which guide employees to take actions in accordance with the organizational strategies and processes＇ goals. The information effect and motive effect of MAS increase employees＇ work satisfaction and their cooperation with each other. In the end, the integration of BPM and MAS improves the organizational economic performance, thus creating value for the organization. The results explain the reason why so much BPM fails in practice, because right assignment, performance evaluation system, and incentive schemes constitute organizational architecture, which is critical to organizational value. Additionally, the value creation of BPM and MAS depends on their coordination with the external environment, the internal situation, and the organizational strategy. From the view of managerial accounting perspective, MAS not only changes with the organization development but also facilitates the organization development.
基金supported by the National Natural Science Foundation of China (51801169)Hong Kong Research Grant Council (CityU Grant 9360161, 9042635, 9042879)the internal funding from the City University of Hong Kong (CityU 9380060)。
文摘Low-carbon advanced nanostructured steels have been developed for various structural engineering applications, including bridges, automobiles, and other strength-critical applications such as the reactor pressure vessels in nuclear power stations. The mechanical performances and applications of these steels are strongly dependent on their microstructural features. By controlling the size,number density, distribution, and types of precipitates, it is possible to produce nanostructured steels with a tensile strength reaching as high as 2 GPa while keeping a decent tensile elongation above 10% and a reduction of area as high as 40%. Besides, through a careful control of strength contributions from multiple strengthening mechanisms, the nanostructured steels with superior strengths and low-temperature impact toughness can be obtained by avoiding the temper embrittlement regime. With appropriate Mn additions, these nanostructured steels can achieve a triple enhancement in ductility(total tensile elongation, TE of ~30%) at no expense of strengths(yield strength, YS of ~1100 to 1300 MPa, ultimate tensile strength, UTS of ~1300 to 1400 MPa). More importantly, these steels demonstrate good fabricability and weldability. In this paper, the microstructure-property relationships of these advanced nanostructured steels are comprehensively reviewed. In addition, the current limitations and future development of these nanostructured steels are carefully discussed and outlined.
