组织驻留记忆T细胞(tissue-resident memory T cells,TRMs)作为一种特殊的记忆T细胞,在免疫应答中发挥着极其重要的作用。其特征是可表达归巢受体,从而具备驻留特性,因此能够驻留在外周组织器官中,当病原体侵袭时可以迅速反应。目前,TR...组织驻留记忆T细胞(tissue-resident memory T cells,TRMs)作为一种特殊的记忆T细胞,在免疫应答中发挥着极其重要的作用。其特征是可表达归巢受体,从而具备驻留特性,因此能够驻留在外周组织器官中,当病原体侵袭时可以迅速反应。目前,TRMs(尤其是CD8+TRMs)与肿瘤的关系及其在抗肿瘤中的应用被愈加重视,一方面是CD8+TRMs可以通过分泌颗粒酶B、穿孔素和INF-γ等因子直接杀伤肿瘤细胞,另一方面一些抗肿瘤措施(如放化疗、免疫治疗等)可以使CD8+TRMs在肿瘤组织中富集,从而进一步提高治疗的效果。本文就CD8+TRMs的亚群分类、在肿瘤中如何调控形成以及其在肿瘤治疗中的作用等方面的研究进展进行综述。展开更多
Introduction. Bullous forms of cutaneous T- cell lymphomas are rare. A new group of cutaneous T- cell lymphomas has recently been identified as a distinct clinicopathological and immunophenotype entity. These cutaneou...Introduction. Bullous forms of cutaneous T- cell lymphomas are rare. A new group of cutaneous T- cell lymphomas has recently been identified as a distinct clinicopathological and immunophenotype entity. These cutaneous T- cell lymphomas express a CD8+ phenotype, rarely expressed in other cutaneous T- cell lymphomas. Case report. We describe a cutaneous CD8+ squamous T- cell lymphoma with polymorphic clinical features, strongly epidermotropic lymphoid infiltrate and spongiosis, classical for this type of lymphoma. Discussion. Bullous lesions in cutaneous T- cell lymphoma should evoke the possibilityofacutaneousCD8+ T- celllymphoma,onceotherbullous diseases have been excluded. Spongiosis, rare in other types of T- cell lymphoma, and strongly epidermotropic pleomorphic lymphoid infiltrate are classical histological features. The association of polymorphic lesions, bullas and atypical CD8+ epidermotropic phenotype should evoke this diagnosis even at the early stage. Treatment is difficult and classical chemotherapy often fails. Prognosis is poor with a mean overall survival of 32 months.展开更多
文摘组织驻留记忆T细胞(tissue-resident memory T cells,TRMs)作为一种特殊的记忆T细胞,在免疫应答中发挥着极其重要的作用。其特征是可表达归巢受体,从而具备驻留特性,因此能够驻留在外周组织器官中,当病原体侵袭时可以迅速反应。目前,TRMs(尤其是CD8+TRMs)与肿瘤的关系及其在抗肿瘤中的应用被愈加重视,一方面是CD8+TRMs可以通过分泌颗粒酶B、穿孔素和INF-γ等因子直接杀伤肿瘤细胞,另一方面一些抗肿瘤措施(如放化疗、免疫治疗等)可以使CD8+TRMs在肿瘤组织中富集,从而进一步提高治疗的效果。本文就CD8+TRMs的亚群分类、在肿瘤中如何调控形成以及其在肿瘤治疗中的作用等方面的研究进展进行综述。
文摘Introduction. Bullous forms of cutaneous T- cell lymphomas are rare. A new group of cutaneous T- cell lymphomas has recently been identified as a distinct clinicopathological and immunophenotype entity. These cutaneous T- cell lymphomas express a CD8+ phenotype, rarely expressed in other cutaneous T- cell lymphomas. Case report. We describe a cutaneous CD8+ squamous T- cell lymphoma with polymorphic clinical features, strongly epidermotropic lymphoid infiltrate and spongiosis, classical for this type of lymphoma. Discussion. Bullous lesions in cutaneous T- cell lymphoma should evoke the possibilityofacutaneousCD8+ T- celllymphoma,onceotherbullous diseases have been excluded. Spongiosis, rare in other types of T- cell lymphoma, and strongly epidermotropic pleomorphic lymphoid infiltrate are classical histological features. The association of polymorphic lesions, bullas and atypical CD8+ epidermotropic phenotype should evoke this diagnosis even at the early stage. Treatment is difficult and classical chemotherapy often fails. Prognosis is poor with a mean overall survival of 32 months.
