细心脑治疗小儿支气管肺炎281例疗效观察

目的:探讨细心脑治疗小儿支气管肺炎的疗效及安全性。方法:回顾2005年1月～2006年12月我科住院确诊为普通支气管肺炎患儿共566例,其中281例(治疗组)加用细心脑治疗;285例(对照组)未用细心脑治疗。疗程约7～10天;分别观察患儿临床症状、体征持续时间,以确定治疗效果。结果:治疗组咳喘、呼吸频率、三凹征、肺部啰音等临床症状和体征均较对照组持续时间短、缓解快(P<0.05)。治疗组总有效率为89.0%,对照组总有效率为80.7%。治疗过程中未见明显不良反应。结论:细心脑注射液佐治小儿支气管肺炎疗效满意,安全可靠,值得在临床推广使用。

细辛脑注射液治疗毛细支气管炎疗效观察

解除呼吸道阻塞、改善通气、控制憋喘是提高毛细支气管炎疗效的关键[1].用细辛脑注射液辅助治疗毛细支气管炎,国内未见报道.本文用细辛脑注射液辅助治疗毛细支气管炎38例收到理想的效果.现总结报告如下:

Neutrophil-to-lymphocyte ratio compared to N-terminal pro-brain natriuretic peptide as a prognostic marker of adverse events in elderly patients with chronic heart failure

Background The neutrophil-to-lymphocyte （N/L） ratio has been associated with poor prognosis in patients with heart failure, but it has not been compared with N-terminal pro-brain natriuretic peptide （NT-proBNP） in elderly patients with chronic heart failure （CHF）. We sought to make this comparison. Methods A total of 1355 elderly patients with CHF were analyzed. A multivariate logistic regression model was used to analyze the variables associated with atrial fibrillation （AF）. Cox regression analysis was used to assess the multivariable rela- tionship between the N/L ratio, NT-proBNP level, and subsequent major cardiovascular events （MCE）. Results In the multiple logistic regression analysis, the N/L ratio was demonstrated as a risk factor for AF in elderly patients with CHF [odds ratio （OR）： 1.079, 95% confi- dence interval （CI）： 1.027-1.134, P = 0.003]. The median follow-up period was 18 months. In a multivariable model using tertiles of both variables, the highest tertile of the N/L ratio was significantly associated with MCE [hazard ratio （HR）： 1.407, 95% CI： 1.098-1.802, P = 0.007] compared with the lowest tertile. Similarly, the highest NT-proBNP tertile was also significantly associated with MCE （HR： 1.461, 95% CI： 1.104-1.934, P- 0.008）. Conclusions In elderly patients with CHF, the N/L ratio is one of the important risk factors for AF and it is an inexpensive and readily available marker with similar independent prognostic power to NT-proBNP. The risk of MCE increases 1.407-fold when the N/L ratio is elevated to the highest tertile.

Diffuse large B-cell lymphoma of cerebellum five months after left atrial myxoma resection in an old woman

We describe a 70-year-old female patient with diffuse large B-cell lymphoma of the cerebellum;she received resection of a left atrial myxoma five months ago.To the best of our knowledge,to date no association of atrial myxoma with the malignant cerebellar diffuse large B-cell lymphoma has been reported in the literature,except for high level of interleukin-6 (IL-6) in the serum under both conditions.IL-6 as a pro-inflammatory cytokine has been shown to be associated with tumor progression,including inhibition of cancer cell apoptosis and stimulation of angiogenesis.IL-6 concentrations may provide possible aetiological links between atrial myxoma and cerebellar diffuse large B-cell lymphoma in our case.

EFFECT OF DESTRUCTION OF NTS AND PVN ON NEIGUAN (PC6)- ELECTROACUPUNCTURE-I NDUCED IMPROVEMENT OF ISCHEMIC MYOCARDIAL CELLULAR MEMBRANE POTENTIALS IN RABBITS

Objective: To observe the influence of electrolytic destruction of nucleus soli tary tract (NTS) and hypothalamic paraventricular nucleus (PVN) on the effect of electroacupuncture (EA) in improving ischemic myocardia cellular transmembrane action potential (TMAP). Methods: 38 Japanese breed big-ear wh ite rabbits (ane sthetized with 20% Urethane, 4 mL/kg) were randomly divided into acute myocardia l ischemia (AMI) group (n=8), PVN destruction group ( n=12) and PVN+NTS destructio n group (n=18). AMI model was established by occlusion of the descending anterio r branch (DAB) of the coronary artery. TMAP of myocytes was recorded by using a glass microelectrode which was fixed to a suspending spring silver wire. Bilater al "Neiguan"(PC 6) in all the 3 groups were punctured and stimulated electri call y by using parameters of continuous waves, frequency of 7 Hz, intensity of 6 mA a nd duration of 30 minutes. Results: After AMI, ECG-ST elevated significantly whil e APA lowered, APD50 and APD90 shortened clearly in comparison with those of pre -AMI in the 3 groups. Compared with AMI group, ECG-ST values of PVN destructi on group and PVN+NTS destruction group were significantly higher (P <0.05～0.01), whi le APA, APD50 and APD90 all significantly lower in all the recording time course s(P<0.05). The facts displayed that electrolytic destru ction of PVN and PVN+NT S could produce ischemic myocardial injury and reduce the protective effect of E A on ischemic myocardial cells. Comparison between PVN destruction and PVN+NTS g roups showed that all the 4 indexes of the later group were evidently worse than those of the former group (P<0.05), suggesting after des truction of these two n uclei, the effect of EA was worsened further. Conclusion: Electrolytic destru ction of PVN and NTS weakens the protective effect of EA on ischemic myocardial cells, both NTS and PVN take part in the effect of EA of "Neiguan"(PC 6) Point i n improving ischemic myocardium.

Roles of hyaluronan in cardiovascular and nervous system disorders

Hyaluronan is a widely occurring extracellular matrix molecule,which is not only a supporting structural component,but also an active regulator of cellular functions.The chemophysical and biological properties of hyaluronan are greatly affected by its molecular size and several hyaluronan-binding proteins,making hyaluronan a fascinating molecule with great functional diversity.This review summarizes our current understanding of the roles of hyaluronan in cardiovascular and nervous system disorders,such as atherosclerosis,myocardial infarction,and stroke,with the aim to provide a foundation for future research and clinical trials.