白马洞断裂新认识及其意义

1白马洞断裂特征贵州白马洞断裂是黔中重要的深大断裂,为纳雍-玉屏深大断裂的重要组成部分,走向75°~80°,长度60 km,倾向变化大,在白马洞一带破碎带宽度较大,一般20~40 m,最宽100 m。破碎带由灰色、黑色、褐黄色片理化断层泥、构造角砾岩、碎裂白云岩、黑色蚀变硅化角砾岩、细粒状黄铁矿、构造透镜体组成,沿走向。

乳房微小钙化点为啥要活检

江苏常州晓琴 我有时会有乳房疼痛不适,去医院就诊,拍了乳腺X线片,发现有微小钙化点,说要穿刺活检。我感觉心里不踏实,请问微小钙化点与乳腺癌有关吗？乳腺癌是成年女性最常见的恶性肿瘤之一,如能早发现、早治疗,则预后较好。在医学影像学检查手段中,以乳腺钼靶X线摄影对显示钙化最为敏感,而早期肿块的钙化是诊断早期乳腺癌的重要征象。当然,钙化也有良恶性之分。

“珍珠汤”的加工方法与烹饪技术

“珍珠汤”是龙南民间的地方菜肴,用精制薯粉加工成珠入高汤、料精烹饪而成。烹饪上碗后,可见碗中珠丸累累、闪闪发光、芳草香花点缀其间、幽香袭人;食之滑润、柔中带韧、清淡香甜、回味无穷。 “珍珠汤”具有滋补降压、清热醒脑、明目又清肠胃的功效。是宴请宾客、防暑祛暑、老少皆宜、价廉物美的上乘佳肴。现将“珍珠汤”

Microstructure,mechanical and shape memory properties of Ti-55Ta-xSi biomedical alloys

The effects of Si addition on microstructures, mechanical and shape memory properties of Ti-55Ta biomedical alloy were investigated. The results show that the microstructures consist of mainly α′′ martensite and a little β phase, and the grain size decreases obviously with increasing Si addition. When x = 0.2, small （Ti, Ta）3Si precipitates are formed at grain boundaries. With further increasing Si content, the amount of the precipitates gradually increases. The tensile and yield strength of Ti-55Ta-xSi alloys gradually increase with increasing Si addition, whereas elongation decreases. Ti-55Ta-0.1Si alloy exhibits the lowest elastic modulus and the best shape memory recoverable strain. It is revealed that the refinement of grain and the precipitation of （Ti, Ta）3Si phase are responsible to the changes of their mechanical and shape memory properties.

云南景洪先坦接触变质交代型磁铁矿

磁铁矿体赋存于元古界澜沧群南勒组(Ptnl)和华力西期花岗岩体(γ34)接触带内,圈定7个矿体,严格交接触带控制,经后期低温热液作用叠加富集。

稀土镁合金的孕育作用

我国球铁生产所用球化剂大多为稀土镁合金。我厂使用南京6~#稀士镁合金,成份为Re6～8％,Mg9～11％,Si≤44％,块状购回,自己破碎,约10％的合金粒度小于工艺要求,不能用作球化剂,重新熔制比较困难,回收也不合算,有效利用这些小颗粒合金有着良好的经济效益。

硫氰酸钾喷雾法显现鞋印与指纹

罪犯留在现场的鞋印通常由尘土构成,这些鞋印常常不明显、不完整、有时不易用肉眼察觉。硫氰酸钾喷雾法是一种新的尘土鞋印增强技术。硫氰酸钾能与尘土中的铁分子起氧化还原反应,使鞋印呈棕红色。这与茚三酮给潜在指纹里的氨基酸上色相类似。

Distribution of Oxytocin Hypothamic-Picuitary-Ovary Axis in Guangxi Local Buffalo

To study the association of oxytocin (OT)'s distribution in hypothalamatic,pituitary and ovary,and understand how the OT secrete releasing in hypothalamus,pituitary and ovaries,the paraffin section immunohistochemistry SuperPicTureTM two step method was used to detect the distribution of OT in hypothalamatic-pituitary-ovary axis of five femal Guangxi local buffalo. The test results could provide morphology according to study the OT's synthesis and mechanism of action,and could play reference and directions part in breeding Guangxi local buffalo. The test results display:oxytocin immuno reactive (OT-IR) neuronsw eremainly distributed arcuate nucleus,supraoptic nucleus and paraventricular nucleus,and OT-IR neurons was also found in ventromedial nucleus,ventrolateralis nucleus,suprachiasmaticus nucleus,dorsomedial nucleus,mamillary body,anterior hypothalamic nucleus and so on. The OT immunoactive production was found in pituitary and few OT-IR nerve fibers extended to post pituitary from hypophyseal stalk and medium eminence. In ovaries,OT immunoactive productions were only distributed in germinal epithelium cells,granulosa cells and lutein cells. The OT was first discovered in singulorum link of hypothalamatic-pituitary-ovary axis of Guangxi local buffalo. The OT immunoactive neurons were first discovered in every main nucleus of Guangxi local buffalo hypothalamus,especially distributed in arcuate nucleus,supraoptic nucleus and paraventricular nucleus.

鲜虾蒲茸饼

这是一款高级汤肴,相传于隋炀帝下扬州看琼花乘龙舟路过淮安府,地方官员为讨好皇帝欢心、特地请了当地有名望的厨师烹制了这道上等汤肴.原料:鲜虾仁350克,鲜蒲菜嫩茎80克,清汤750克,猪肥肉泥20克,蛋清1只, 菜心8只,葱15克,姜5克,盐。

薯蓣的鉴别要点

1.药材鉴别商品中药材,由于加工方法不同分为毛山药和光山药。毛山药：外观形状不一,多为扁圆形,略弯曲之柱体状,长15-30 cm,直径1.5-6 cm,表面灰白色至黄白色,有明显的皱缩及栓皮未除尽的痕迹,或有小疙瘩,两头不齐。质坚脆,易折断,断面白色,粉性足,显颗粒性。气微,味甘淡而微酸。光山药：呈圆柱形,长10-20 cm,直径1.5-3 cm,

拉线铁塔安装地锚时应注意的问题

正确安装地锚是消除拉线铁塔故障的关键。为使铁塔在整个寿命期内不倾斜或不需要经常调节拉线,安装人员必须: a.掌握安装地锚处的泥土性质和环境。 b.要考虑泥土季节性变化,如地下水位上升或冻土的融化。 c.使用尽可能长的拉线,以减少载荷。 d.地锚尺寸要与载荷适应,埋土深度要与泥土情况相配。泥土主要分为两大类:粘性泥土和非粘性泥土。粘性泥土又细分为软土、结实的泥土等。非粘性泥土,可分为松土、密实的泥土等。问题是,泥土的情况实际上更为复杂,如泥土很少是均匀的。

碟形刀盘的热处理

碟形刀盘锻件毛坯采用球化退火,或调质预处理得到细粒球状珠光体或微细晶粒的索氏体组织,经高频加热、加压、淬火得到细针状+隐晶马氏体的工艺方法,使刀盘刃部达到高硬度、高强轫性,刃口锋利而耐磨的优良性能,且变形小。

The effect of Jujuboside A on the evoked field potentials of Granule cells in dentate gyrus

Jujuboside A (JuA) is a main component of Jujubogenin extracted from the seeds of Ziziphus. The authors have not seen any report on JuA's direct effect on the neurons of the central nervous system. This study aimed to assess the effect of JuA on paired pulse responses of dentate gyrus granule cells in urethane anaesthetized rats, used intracerebroventricular (i.c.v.) JuA to mimic in vitro bath conditions in vivo. Paired pulse stimuli with 80ms interpulse interval were used to stimulate the perforant pathway. Evoked responses were recorded in the dentate gyrus cell layer after i.c.v. administration of 0.9% normal saline or JuA. In the first responses, the slopes of excitatory postsynaptic potential (EPSP1) and the amplitudes of population spike (PS1) decreased significantly after administration of JuA while the PS1 latencies increased significantly. In the second responses, the EPSP2 slopes and PS2 latencies were changed similarly to those of the first ones, but PS2 amplitudes increased. The results showed that JuA may have some inhibitory effect on the granule cell excitability mediated by presynaptic mechanism but may have little effect on the excitability mediated by postsynaptic mechanism since the second evoked N methyl D aspartic mediating paired pulse facilitation is a postsynaptic mechanism.

Kinetic grain growth, shape memory and corrosion behavior of two Cu-based shape memory alloys after thermomechanical treatment

Metallurgical and mechanical properties along with shape memory and corrosion behavior of Cu-11.8% AI-3.7% Ni-1 %Mn and Cu-11% A1 5.6% Mn shape memory alloys （SMAs） were comparatively studied. The influence of grain refinement on the properties was studied by optical microscopy （OM）, scanning electron microscopy （SEM）, differential scanning calorimetry （DSC）, potentiodynamic polarizations and bend and tensile tests. Static recrystallization and kinetic grain growth show a rapid recrystallization in the first 15 s of annealing at 800℃ followed by grain growths. The minimum grain sizes obtained after 15 s are 90 and 260 μm for Cu-A1-Ni-Mn and Cu-A1-Mn, respectively. Tensile tests show typical three-stage curves for both alloys, and it is seen that alloys exhibit high fracture stress and strain after grain refinement. Microstructural observations show zig-zag morphology of β 1martensite in the Cu-A1-Ni-Mn and coexistence of β1 and y1 in the Cu-A1-Mn, which were confirmed by differential scanning calorimetry results. The shape memory ratios （17） of the alloys before thermomechanieal treatment, and after thermomechanical annealing at 800 ℃ for different time up to 15 min followed by water quenching, were evaluated. In addition, corrosion behavior of alloys after grain refinement was analyzed by means of potentiodynamic polarization measurements. The results showed that the anodic reactions were dominated by dissolution of copper, and Cu-AI-Ni-Mn alloy exhibits a better corrosion resistance than Cu-A1-Mn alloy.

“雌黄”何以入成语

雌黄,是一种可以用来制作颜料或褪色剂的矿物,其化学成分为三硫化二砷（As2S3）,呈柠檬黄色,晶体多为细粒状、片状或柱状,多有珍珠光泽,半透明。古代馆阁新书净本写了错别字。

Clinical significance of telomerase and its associate genes expression in the maintenance of telomere length in squamous cell carcinoma of the esophagus

AIM: To observe the interaction between the expression of telomerase activity (TA) and its associate genes in regulation of the terminal restriction fragment length(TRFL) in esophageal squamous cell carcinoma (SCC).METHODS: Seventy-four specimens of esophageal SCC were examined. The TA was measured by telomeric repeat amplification protocol (TRAP) assay, and the associated genes [human telomerase-specific reverse transcriptase (hTERT), hTERC, TP1, c-Myc, TRF1,and TRF2] were detected using RT-PCR method. The TRFL was measured by Telomere Length Assay Kit and Southern blotting. The correlations between the expression of telomerase and its associated genes with the TRFL and survivals were examined.RESULTS: Expressions of the TA, hTERT, hTERC, TP1,c-Myc, TRF1, and TRF2 genes were observed in 85.1%,64.9%, 79.7%, 100.0%, 94.6%, 82.4%, and 91.9% of the tumor tissues, respectively. The TRFL of the tumor and normal esophageal tissues were 2.70±1.42 and 4.93±1.74 kb, respectively (P＜0.0001). The TRFL of the telomerase positive and telomerase negative tumor tissues were 2.72±1.44 and 2.58±1.32 kb, respectively (P = 0.767).The TRFL ratios (TRFLR) of the telomerase positive and telomerase negative tumor tissues were 0.55±0.22 and 0.59±0.41, respectively (P = 0.742). The expression rates of h-TERT (P = 0.0002), hTERC (P＜0.0001), and TRF1(P = 0.002) in the tumor tissues are higher than those of the normal paired tissues. Though TA is markedly activated in tumor tissues (P＜0.0001), its expression is not related to clinicopathological parameters including gender, tumor differentiation, and TNM stages. The cumulative 4-year survival rates of telomerase positive and telomerase negative cases were 35.86% and 31.2%,respectively (P = 0.8442). The cumulative 4-year survival rates of patients with their TRFLR ≤85% and ＞85%were 38.7% and 15.7%, respectively (P = 0.1307).CONCLUSION: Though telomerase expression is not related to tumor stages and prognosis, our data support that the TA increased as the TRFL decreased,probably under the control of hTERT, hTERC, and TRF1.When telomerase expression was activated, only TRF2overexpression persisted to stabilize T-loop formation.Furthermore, as the TRFLR decreased to 85%, a trend of better prognosis was observed. Cox model analysis indicates a higher t/n TRFLR and distant metastasis are independent poorer prognostic factors (P = 0.035 and P = 0.042, respectively).

Helicobacter pylori infection and gastropathy:A comparison between Indonesian and Japanese patients

AIM： To compare the effects of He/icobacter py/ori （Hpylon） infection on gastropathy between Indonesian and Japanese patients. METHODS： Biopsy specimens were obtained during upper gastrointestinal endoscopy from 167 subjects （125 Indonesians and 42 Japanese） with uninvestigated symptoms of dyspepsia. The specimens were analyzed for the presence of H pylori using urease analysis, histopathology, and cell culture. The grade and activity of gastritis was assessed using the updated Sydney system. RESULTS： The percentages of Indonesian and Japanese patients who were H py/ori-positive at the antrum or body of the stomach were similar （68% and 59.5%, respectively; P = 0.316）. Of those who were Hpylori-positive, more Japanese patients than Indonesian patients had high levels of polymorphonuclear cells （P = 0.001）, mononuclear cells （P = 0.013）, glandular atrophy （P = 0.000）, and intestinal metaplasia （P = 0.011） in both the antrum and body of the stomach. CONCLUSION： The grade of gastritis and prevalence of mucosal atrophy and intestinal metaplasia were higher in Japanese patients. The difference between Indonesian and Japanese patients was significant.

Influence of anti-keratin autoantibodies on telomerase activity of squa-mous cell carcinoma

Objective: To investigate the influence of anti-keratin autoantibodies (AK auto Abs) on telom-erase activity of squamous cell carcinoma cultured in vitro and the mechanisms of the inhibitory effects of AK auto Abs on squamous cell carcinoma. Methods: Influence of AK auto Abs on the proliferation of Tca cells was observed by MTT colorimetry. Telomerase activity of cultured Tca cells and human keratinocytes was determined by telomeric repeat amplication protocol-ELISA (TRAP-ELISA) and polyacrylamide gel elec-trophoresis (PAGE). After being treated with AK auto Abs for 36 h at a concentration of 4, 8, 16 mg/L respectively, the changes of telomerase activity of Tea cells were also detected by TRAP-ELISA and PAGE. Results: MTT colorimetric determination showed that the capacity of proliferation of Tca cells correlated negatively with the concentration of AK auto Abs (r= -0. 74, P<0. 01). TRAP-ELISA and PAGE showed that telomerase activity of Tca cells increased significantly compared to that of cultured human keratinocytes (t = 3. 5396, P<0. 01). AK auto Abs at a concentrations of 4, 8, 16 mg/L had significant dose-dependent inhibitory effects on telomerase activity of Tca cells (r= - 0. 8358, P<0. 01). Conclusion: AK auto Abs have a significant dose-dependent inhibitory effect on the proliferation of cultured Tea cells. AK auto Abs inhibit telomerase activity of cultured Tca cells with dose-dependent pattern. It suggests that decrease of telomerase activity may play an important role in the inhibitory effects of AK auto Abs on squamous cell carcinoma.

Change and Signif icance of Mitochondrial DNA Copy Number in Esophageal Squamous Cell Carcinoma

OBJECTIVE To compare the differences of mitochondrial DNA (mtDNA) copies among the tissues of esophageal squamous cell carcinoma (ESCC), para-neoplastic tissue and normal mucous membrane of the esophagus, and to study the relationship between the mtDNA and the occurrence and devel- opment of esophageal squamous cell carcinoma. METHODS The mtDNA copies of 42 specimens with the ESCC, paraneoplastic mucous tissue and normal mucous membrane of the esophagus were determined using real-time fluorescence quantitative PCR. The mtDNA was analyzed using agarose gel electrophoresis. RESULTS The mtDNA from all of the tissues (42/42) from the ESCC, para-neoplastic tissue and normal esophageal mucous membranes was analyzed, showing that there were an average mtDNA copy number of 27.1894×106 μg DNA, 9.4102×106 μg DNA and 5.9347×106 μg DNA, from the respective tissues. There were signifi cant differences (F=27.83, P<0.05) in mtDNA copy number among the three. A positive band was shown at 403 bp after gel electrophoresis of the PCR products, and the lane where the ESCC mtDNA located was rather bright, which was in accordance with the result of the real-time PCR determination. CONCLUSION An increase in the mtDNA copy number is related to the occurrence and development of ESCC.

Vaccination with dendritic cells pulsed with hepatitis C pseudo particles induces specific immune responses in mice

AIM: To explore dendritic cells (DCs) multiple functions in immune modulation. METHODS: We used bone-marrow derived dendritic cells from BALB/c mice pulsed with pseudo particles from the hepatitis C virus to vaccinate naive BALB/c mice. Hepatitis C virus (HCV) pseudo particles consist of the genotype 1b derived envelope proteins E1 and E2, covering a non-HCV core structure. Thus, not a single epitope, but the whole "viral surface" induces immunogenicity. For vaccination, mature and activated DC were injected subcutaneously twice. RESULTS: Humoral and cellular immune responses measured by enzyme-linked immunosorbent assay and interferon-gamma enzyme-linked immunosorbent spot test showed antibody production as well as T-cellsdirected against HCV. Furthermore, T-cell responses confi rmed two highly immunogenic regions in E1 and E2 outside the hypervariable region 1. CONCLUSION: Our results indicate dendritic cells as a promising vaccination model for HCV infection that should be evaluated further.