目的 观察凋亡调节蛋白的表达与脑膜瘤级别和复发的关系。方法 用LSAB免疫组织化学方法对80例脑膜瘤细胞中凋亡调节蛋白Bcl-2、Bax、BcL-XL的表达进行分析。结果 恶性组Bcl-2瘤蛋白阳性率(88％)明显高于良性组(37％，P＞0.05)。分别比...目的 观察凋亡调节蛋白的表达与脑膜瘤级别和复发的关系。方法 用LSAB免疫组织化学方法对80例脑膜瘤细胞中凋亡调节蛋白Bcl-2、Bax、BcL-XL的表达进行分析。结果 恶性组Bcl-2瘤蛋白阳性率(88％)明显高于良性组(37％，P＞0.05)。分别比较良性组、非典型组、恶性组中Bax、BcL-XL癌蛋白表达阳性率，无显著性差异(P＞0.05)。而Bcl-2+BcL-XL／Bax与脑膜瘤级别有统计学相关性(P＞0.01)。非复发组、复发组首次手术组、再次复发组中Bcl-2、Bax、BcL-XL，癌蛋白阳性率两两比较均无显著性差异(P＞0.05)。结论 Bcl-2、Bax、BcL-XL在脑膜瘤发生中起调节作用，BcL-2+BcL-XL／Bax是脑膜瘤生物学行为的有效检测法。 Objective To explore the relationship between expression of apoptosis-modulating proteins and histopathological grade and recurrence in meningioma.Methods Immunohistochemistry method (LSAB) was used to detect the expression of Bcl-2, Bax and Bcl-Xt in 80 cases of meningioma including benign group (38 cases), atypical group (26 cases) and malignant group (16 cases).Results Expression of Bcl-2 oncoprotein positive in 88% cases in malignant group was significantly higher than that of benign group (37%, P < 0.05 ). There was no significant difference in the expression positive rate of Bax, Bcl-XL oncoprotein among benign, atypical and maligant groups (P > 0.05 ), but Bcl-2 + Bcl-XL/Bax was associated statistically with meningioma grade (P <0. 01 ). There was no significant difference in the compare expression of Bcl-2, Bax, Bcl-XL oncoprotein positive in non-recurrent,initially resected recurrent and recurrent meningiomas (P >0.05).Conclusion Bcl-2, Bax and Bcl-XL might play important roles in meningiomas and BCL-2 + BCL-XL/Bax is useful parameters for estimation of biological behavior of meningiomas.展开更多
文摘目的 观察凋亡调节蛋白的表达与脑膜瘤级别和复发的关系。方法 用LSAB免疫组织化学方法对80例脑膜瘤细胞中凋亡调节蛋白Bcl-2、Bax、BcL-XL的表达进行分析。结果 恶性组Bcl-2瘤蛋白阳性率(88％)明显高于良性组(37％，P＞0.05)。分别比较良性组、非典型组、恶性组中Bax、BcL-XL癌蛋白表达阳性率，无显著性差异(P＞0.05)。而Bcl-2+BcL-XL／Bax与脑膜瘤级别有统计学相关性(P＞0.01)。非复发组、复发组首次手术组、再次复发组中Bcl-2、Bax、BcL-XL，癌蛋白阳性率两两比较均无显著性差异(P＞0.05)。结论 Bcl-2、Bax、BcL-XL在脑膜瘤发生中起调节作用，BcL-2+BcL-XL／Bax是脑膜瘤生物学行为的有效检测法。 Objective To explore the relationship between expression of apoptosis-modulating proteins and histopathological grade and recurrence in meningioma.Methods Immunohistochemistry method (LSAB) was used to detect the expression of Bcl-2, Bax and Bcl-Xt in 80 cases of meningioma including benign group (38 cases), atypical group (26 cases) and malignant group (16 cases).Results Expression of Bcl-2 oncoprotein positive in 88% cases in malignant group was significantly higher than that of benign group (37%, P < 0.05 ). There was no significant difference in the expression positive rate of Bax, Bcl-XL oncoprotein among benign, atypical and maligant groups (P > 0.05 ), but Bcl-2 + Bcl-XL/Bax was associated statistically with meningioma grade (P <0. 01 ). There was no significant difference in the compare expression of Bcl-2, Bax, Bcl-XL oncoprotein positive in non-recurrent,initially resected recurrent and recurrent meningiomas (P >0.05).Conclusion Bcl-2, Bax and Bcl-XL might play important roles in meningiomas and BCL-2 + BCL-XL/Bax is useful parameters for estimation of biological behavior of meningiomas.
