补体攻膜复合物细胞非致死性效应及其信号转导机制

有核细胞能通过自身机制抵抗同源补体溶破 ,同时亚溶破 MAC在细胞膜上沉积后 ,能刺激多种细胞的多种生物学活性改变 ,包括产生活性氧、释放花生四烯酸及其代谢产物、产生多种细胞因子、诱导膜蛋白表达和诱导细胞进入细胞周期等 ,此称 MAC的细胞非致死效应。这些效应是由 MAC活化细胞跨膜信号转导机制介导的。

The molecular mechanisms of Yang Wei Kang Liu powder on anticancer and reducing chemotherapy side-effect in combination with chemotherapy

Objective:We studied the molecular mechanisms of Yang Wei Kang Liu Power(YWKL,traditional Chinese medicine for nourishing stomach and anticancer) on anticancer and reducing chemotherapy side-effect in combination with chemotherapy.Methods:615 pre-cancer mouse model of YWKL for 10 days and CTX 1 time,semi-quantitative reverse transcription-polymerase chain reaction(RT-PCR) to detect bone marrow granulocyte-macrophage colony-stimulating factor(GM-CSF) gene and cancer proto-oncogene Bcl-2,c-myc expression.Results:YWKL in combination with chemotherapy could obviously promoted the expression of GM-CSF gene and inhibited the expression of Bcl-2 and c-myc oncogenes of FC 615 mice.Conclusion:The molecular mechanisms of anticancer and reducing chemotherapy side-effect of YWKL in combination with chemotherapy are to promote the expression of GM-CSF gene and inhibit the expression of Bcl-2 and c-myc oncogenes.

膜攻击复合物C5b-9的研究现状

C5b-9也称膜攻击复合物，是补体系统经经典、旁路和凝集素三条途径激活后形成的共同末端效应产物。近年来，国内外许多研究发现沉积于细胞表面的C5b-9能刺激多种细胞的多种生物学活性改变，包括产生炎性介质、细胞因子，并诱导膜蛋白表达等，C5b-9的这种细胞刺激效应在多种疾病的发病机制和病程进展中发挥作用，尤其是亚溶解型C5b-9，在炎症、神经系统疾病、肾脏病和动脉粥样硬化等疾病中具有致病等多重作用。