Study of cell-in-cell phenomena began with the desire to understand the complex phenotype, which stemmed from Lewis＇ observation ofnon-phagocytotic process of cell-eating-cell in 1925. Humble et al. coined the term ...Study of cell-in-cell phenomena began with the desire to understand the complex phenotype, which stemmed from Lewis＇ observation ofnon-phagocytotic process of cell-eating-cell in 1925. Humble et al. coined the term ＂emperipolesis＂ （from the Greek, wandering round about within） in 1950s, to define the heterogeneous cell-in-cell phenomena when they studied bio- logical interaction of lymphocytes with other cells . Emperipolesis has since been found to be commonly enacted by lymphocytes in physiological and pathophysiological settings . Since the term ＂emperipolesis＂ was annotated, a challenge has been set to understand how a cell inhabits in the other, what are their respective fates, and the biological relevance of co-habitation.展开更多
文摘Study of cell-in-cell phenomena began with the desire to understand the complex phenotype, which stemmed from Lewis＇ observation ofnon-phagocytotic process of cell-eating-cell in 1925. Humble et al. coined the term ＂emperipolesis＂ （from the Greek, wandering round about within） in 1950s, to define the heterogeneous cell-in-cell phenomena when they studied bio- logical interaction of lymphocytes with other cells . Emperipolesis has since been found to be commonly enacted by lymphocytes in physiological and pathophysiological settings . Since the term ＂emperipolesis＂ was annotated, a challenge has been set to understand how a cell inhabits in the other, what are their respective fates, and the biological relevance of co-habitation.
