This paper presents a development o f the extended Cellular Automata9CA),based on relational databases(RDB),to model dynamic interactions amon g spatial objects.The integration o f Geographical Information System(GIS)...This paper presents a development o f the extended Cellular Automata9CA),based on relational databases(RDB),to model dynamic interactions amon g spatial objects.The integration o f Geographical Information System(GIS)and CA has the great advantage of simu lationg geographical processes.But standard CA has some restrictions i n cellular shape and neighbourhood and neighbour rules,which restrict the CA’ s ability to simulate complex,real world environ-ments.This paper discusses a cell’ s spatialrelationbasedonthe spatialobject’ s geometricalandmon -geometricalc haracter-istics,and extends the cell’ s neighbour definition,and considers that the cell’ s neighbour lies in the forms of not on ly spa-tial adjacency but also attribute co rrelation.This paper then puts forw ard that spatial relations between t wo different cells can be divided into three types,including spatial adjacency,neighbour hood and complicated separation.Ba sed on tradition-al ideas,it is impossible to settle CA’ s restrictions completely.RDB -based CA is an academic experiment,in which some fields ard desighed to describe the essential information needed to define and select a cell’ s neighbour.The culture innovation diffusion system has mul tiple forms of space diffusion and in herited characteristics that the RD B -based CA is capable of simulating more effectiv ely.Finally this paper details a successful case study on the diffusion o f fashion wear trends.Compared to the original CA,the RDB -based CA is a more natural and efficient representation of human k nowl-edge over space,and is an effective t ol in simulation complex systems that have multiple forms of spatial diff usion.展开更多
Rising worldwide cancer incidence and resistance to current anti-cancer drugs necessitate the need for new pharmaceutical compounds and drug delivery system. Malfunction of the immune system, particularly in the tumor...Rising worldwide cancer incidence and resistance to current anti-cancer drugs necessitate the need for new pharmaceutical compounds and drug delivery system. Malfunction of the immune system, particularly in the tumor microenvironment, causes tumor growth and enhances tumor progression. Thus, cancer immunotherapy can be an appropriate approach to provoke the systemic immune system to combat tumor expansion. Texosomesj which are endogenous nanovesicles released by all tumor cells, contribute to cell-cell communication and modify the phenotypic features of recipient cells due to the texosomes＇ ability to transport biological components. For this reason, texosome-based delivery system can be a valuable strategy for therapeutic purposes. To improve the pharmaceutical behavior of this system and to facilitate its use in medical applications, biotechnology approaches and mimetic techniques have been utilized. In this review, we present the development history oftexosome-based delivery systems and discuss the advantages and disadvantages of each system.展开更多
文摘This paper presents a development o f the extended Cellular Automata9CA),based on relational databases(RDB),to model dynamic interactions amon g spatial objects.The integration o f Geographical Information System(GIS)and CA has the great advantage of simu lationg geographical processes.But standard CA has some restrictions i n cellular shape and neighbourhood and neighbour rules,which restrict the CA’ s ability to simulate complex,real world environ-ments.This paper discusses a cell’ s spatialrelationbasedonthe spatialobject’ s geometricalandmon -geometricalc haracter-istics,and extends the cell’ s neighbour definition,and considers that the cell’ s neighbour lies in the forms of not on ly spa-tial adjacency but also attribute co rrelation.This paper then puts forw ard that spatial relations between t wo different cells can be divided into three types,including spatial adjacency,neighbour hood and complicated separation.Ba sed on tradition-al ideas,it is impossible to settle CA’ s restrictions completely.RDB -based CA is an academic experiment,in which some fields ard desighed to describe the essential information needed to define and select a cell’ s neighbour.The culture innovation diffusion system has mul tiple forms of space diffusion and in herited characteristics that the RD B -based CA is capable of simulating more effectiv ely.Finally this paper details a successful case study on the diffusion o f fashion wear trends.Compared to the original CA,the RDB -based CA is a more natural and efficient representation of human k nowl-edge over space,and is an effective t ol in simulation complex systems that have multiple forms of spatial diff usion.
文摘Rising worldwide cancer incidence and resistance to current anti-cancer drugs necessitate the need for new pharmaceutical compounds and drug delivery system. Malfunction of the immune system, particularly in the tumor microenvironment, causes tumor growth and enhances tumor progression. Thus, cancer immunotherapy can be an appropriate approach to provoke the systemic immune system to combat tumor expansion. Texosomesj which are endogenous nanovesicles released by all tumor cells, contribute to cell-cell communication and modify the phenotypic features of recipient cells due to the texosomes＇ ability to transport biological components. For this reason, texosome-based delivery system can be a valuable strategy for therapeutic purposes. To improve the pharmaceutical behavior of this system and to facilitate its use in medical applications, biotechnology approaches and mimetic techniques have been utilized. In this review, we present the development history oftexosome-based delivery systems and discuss the advantages and disadvantages of each system.
