Direction relation is an important spatial relation. Descriptions and representations for direction relations have different levels of detail because of the varying dimensions of spatial objects and different scales o...Direction relation is an important spatial relation. Descriptions and representations for direction relations have different levels of detail because of the varying dimensions of spatial objects and different scales of the embedding spaces. Based on a direction- relation matrix, the hierarchical frame of spatial direction relations which partitions direction relations orderly and thoroughly is built. Interior direction relations are used to perfect the representation of direction relations and the binary-encoding idea is creatively applied to construct an interior detailed matrix describing multiple interior direction relations by a uniform matrix. The model integrates topological information into the description model for direction relations, which will lay the foundations of spatial compositive reasoning.展开更多
AIM: To assess the absolute number of T-regulatory cells (Tregs; CD4+CD25+Foxp3+) in the peripheral blood of gastric and colorectal cancer patients. METHODS: We enrolled 70 cancer patients (33 gastric cancer, 37 color...AIM: To assess the absolute number of T-regulatory cells (Tregs; CD4+CD25+Foxp3+) in the peripheral blood of gastric and colorectal cancer patients. METHODS: We enrolled 70 cancer patients (33 gastric cancer, 37 colorectal cancer) and 17 healthy volunteers. The CD3+CD4+ lymphocytes and CD4+CD25+Foxp3+ Tregs in the peripheral blood were analyzed with flow cytometry. The absolute numbers of Tregs were calculated based on the CD4+CD25+Foxp3+ cells percent-age of CD3+CD4+ cells and the absolute numbers of CD3+CD4+ cells per microliter. RESULTS: The mean number of CD4+CD25+Foxp3+ cells per microliter in colorectal cancer patients was 15.7 (SD: 21.8), for gastric cancer patients 12.2 (SD: 14.3), and for controls 17.5 (SD: 11.4). The absolute number of Tregs was significantly lower in gastric cancer patients than in controls (P = 0.026). There was no statistically significant difference for gastric vs colorectal cancer or colorectal cancer vs controls. The absolute number of Tregs was also significantly depressed in N+ vs Ncancer patients [22.0 (27.7) vs 10.1 (9.0), P = 0.013], and in the subgroup of gastric cancer patients [30.3 (27.6) vs 9.6 (8.0), P = 0.003]. No statistical difference was observed in the proportion of Tregs in the CD4+ population between the groups. CONCLUSION: The absolute number of Tregs in peripheral blood of gastric cancer but not colorectal cancer patients was significantly decreased in comparison with that in healthy controls.展开更多
Direct shear tests were conducted on the rock joints under constant normal load(CNL), while the acoustic emission(AE) signals generated during shear tests were monitored with PAC Micro-II system. Before and after shea...Direct shear tests were conducted on the rock joints under constant normal load(CNL), while the acoustic emission(AE) signals generated during shear tests were monitored with PAC Micro-II system. Before and after shearing, the surfaces of rock joints were measured by the Talysurf CLI 2000. By correlating the AE events with the shear stress-shear displacement curve, one can observe four periods of the whole course of shearing of rock joints. By the contrast of AE location and actual damage zone, it is elucidated that the AE event is related to the morphology of the joint. With the increase of shearing times, the shear behavior of rock joints gradually presents from the response of brittle behavior to that of ductile behavior. By combining the results of topography measurement, four morphological parameters of joint surface, S p(the maximum height of joint surface), N(number of islands), A(projection area) and V(volume of joint) were introduced, which decrease with shearing. Both the joint roughness coefficient(JRC) and joint matching coefficient(JMC) drop with shearing, and the shear strength of rock joints can be predicted by the JRC-JMC model. It establishes the relationship between micro-topography and macroscopic strength, which have the same change rule with shearing.展开更多
Osteoarthritis(OA)is a degenerative articular disorder manifested by cartilage destruction,subchondral sclerosis,osteophytes,and synovitis,resulting in chronic joint pain and physical disability in the elderly.The pur...Osteoarthritis(OA)is a degenerative articular disorder manifested by cartilage destruction,subchondral sclerosis,osteophytes,and synovitis,resulting in chronic joint pain and physical disability in the elderly.The purpose of this study was to investigate mitochondrial DNA copy number(mtDNACN)and inflammatory cytokines in primary knee OA patients and healthy volunteers.A total of 204 knee OA patients and 169 age-matched healthy volunteers were recruited.Their relative blood leukocyte mtDNACN was assessed by quantitative real-time polymerase chain reaction(qRT-PCR),and ten inflammatory cytokines in their plasma were detected by multiplex immunoassay.Blood leukocyte mtDNACN in the OA group was significantly lower than that in the control group.Leukocyte mtDNACN in the control group was negatively correlated with their age(r=−0.380,P<0.0001),whereas mtDNACN in the OA group was positively correlated with their age(r=0.198,P<0.001).Plasma interleukin-4(IL-4)and IL-6 were significantly higher in the knee OA group than in the control group.The plasma IL-6 level was positively correlated with blood leukocyte mtDNACN in the OA group(r=0.547,P=0.0014).IL-5 showed as a major factor(coefficient 0.69)in the second dimension of principle components analysis(PCA)-transformed data and was significantly higher in the OA group(P<0.001)as well as negatively correlated with mtDNACN(r=−0.577,P<0.001).These findings suggest that elevation of plasma IL-4 and IL-6 and a relative reduction in mtDNACN might be effective biomarkers for knee OA.IL-5 is a plausible factor responsible for decreasing blood leukocyte mtDNACN in knee OA patients.展开更多
文摘Direction relation is an important spatial relation. Descriptions and representations for direction relations have different levels of detail because of the varying dimensions of spatial objects and different scales of the embedding spaces. Based on a direction- relation matrix, the hierarchical frame of spatial direction relations which partitions direction relations orderly and thoroughly is built. Interior direction relations are used to perfect the representation of direction relations and the binary-encoding idea is creatively applied to construct an interior detailed matrix describing multiple interior direction relations by a uniform matrix. The model integrates topological information into the description model for direction relations, which will lay the foundations of spatial compositive reasoning.
基金Supported by Ministry of Science and Higher Education of Poland Grants 2P05C 001 29 and K/PBW/000421
文摘AIM: To assess the absolute number of T-regulatory cells (Tregs; CD4+CD25+Foxp3+) in the peripheral blood of gastric and colorectal cancer patients. METHODS: We enrolled 70 cancer patients (33 gastric cancer, 37 colorectal cancer) and 17 healthy volunteers. The CD3+CD4+ lymphocytes and CD4+CD25+Foxp3+ Tregs in the peripheral blood were analyzed with flow cytometry. The absolute numbers of Tregs were calculated based on the CD4+CD25+Foxp3+ cells percent-age of CD3+CD4+ cells and the absolute numbers of CD3+CD4+ cells per microliter. RESULTS: The mean number of CD4+CD25+Foxp3+ cells per microliter in colorectal cancer patients was 15.7 (SD: 21.8), for gastric cancer patients 12.2 (SD: 14.3), and for controls 17.5 (SD: 11.4). The absolute number of Tregs was significantly lower in gastric cancer patients than in controls (P = 0.026). There was no statistically significant difference for gastric vs colorectal cancer or colorectal cancer vs controls. The absolute number of Tregs was also significantly depressed in N+ vs Ncancer patients [22.0 (27.7) vs 10.1 (9.0), P = 0.013], and in the subgroup of gastric cancer patients [30.3 (27.6) vs 9.6 (8.0), P = 0.003]. No statistical difference was observed in the proportion of Tregs in the CD4+ population between the groups. CONCLUSION: The absolute number of Tregs in peripheral blood of gastric cancer but not colorectal cancer patients was significantly decreased in comparison with that in healthy controls.
基金Projects(51274249,51174228)supported by the National Natural Science Foundation of China
文摘Direct shear tests were conducted on the rock joints under constant normal load(CNL), while the acoustic emission(AE) signals generated during shear tests were monitored with PAC Micro-II system. Before and after shearing, the surfaces of rock joints were measured by the Talysurf CLI 2000. By correlating the AE events with the shear stress-shear displacement curve, one can observe four periods of the whole course of shearing of rock joints. By the contrast of AE location and actual damage zone, it is elucidated that the AE event is related to the morphology of the joint. With the increase of shearing times, the shear behavior of rock joints gradually presents from the response of brittle behavior to that of ductile behavior. By combining the results of topography measurement, four morphological parameters of joint surface, S p(the maximum height of joint surface), N(number of islands), A(projection area) and V(volume of joint) were introduced, which decrease with shearing. Both the joint roughness coefficient(JRC) and joint matching coefficient(JMC) drop with shearing, and the shear strength of rock joints can be predicted by the JRC-JMC model. It establishes the relationship between micro-topography and macroscopic strength, which have the same change rule with shearing.
基金Project supported by the 90th Anniversary of Chulalongkorn University(No.RA61/104)the Research Chair Grant from the National Science and Technology Development Agency+1 种基金the 100th Anniversary of Chulalongkorn University Fund for Doctoral Scholarshipthe Overseas Research Experience Scholarship for Graduate Student,Thailand and China Scholarship Council,China
文摘Osteoarthritis(OA)is a degenerative articular disorder manifested by cartilage destruction,subchondral sclerosis,osteophytes,and synovitis,resulting in chronic joint pain and physical disability in the elderly.The purpose of this study was to investigate mitochondrial DNA copy number(mtDNACN)and inflammatory cytokines in primary knee OA patients and healthy volunteers.A total of 204 knee OA patients and 169 age-matched healthy volunteers were recruited.Their relative blood leukocyte mtDNACN was assessed by quantitative real-time polymerase chain reaction(qRT-PCR),and ten inflammatory cytokines in their plasma were detected by multiplex immunoassay.Blood leukocyte mtDNACN in the OA group was significantly lower than that in the control group.Leukocyte mtDNACN in the control group was negatively correlated with their age(r=−0.380,P<0.0001),whereas mtDNACN in the OA group was positively correlated with their age(r=0.198,P<0.001).Plasma interleukin-4(IL-4)and IL-6 were significantly higher in the knee OA group than in the control group.The plasma IL-6 level was positively correlated with blood leukocyte mtDNACN in the OA group(r=0.547,P=0.0014).IL-5 showed as a major factor(coefficient 0.69)in the second dimension of principle components analysis(PCA)-transformed data and was significantly higher in the OA group(P<0.001)as well as negatively correlated with mtDNACN(r=−0.577,P<0.001).These findings suggest that elevation of plasma IL-4 and IL-6 and a relative reduction in mtDNACN might be effective biomarkers for knee OA.IL-5 is a plausible factor responsible for decreasing blood leukocyte mtDNACN in knee OA patients.
