细菌非编码小RNA（non-coding small RNA,简称sRNA）是一类长度为40~500个核苷酸,在基因组中被转录但不编码蛋白质的一类RNA分子。它们大多数在Hfq的协助下,通过碱基配对识别靶标mRNA,在转录后水平调节基因的表达,是细菌代谢、群体感应...细菌非编码小RNA（non-coding small RNA,简称sRNA）是一类长度为40~500个核苷酸,在基因组中被转录但不编码蛋白质的一类RNA分子。它们大多数在Hfq的协助下,通过碱基配对识别靶标mRNA,在转录后水平调节基因的表达,是细菌代谢、群体感应和适应环境变化及毒力基因表达的重要调节因子。本文对sRNA的分类及功能作如下综述。展开更多
Fifty bacterial strains isolated from dairy product, skin and blood from cancer and kidney failure dialysis patients were identified to 22 species and the following genera： Brevibacterium, Corynebacterium, Arthrobact...Fifty bacterial strains isolated from dairy product, skin and blood from cancer and kidney failure dialysis patients were identified to 22 species and the following genera： Brevibacterium, Corynebacterium, Arthrobacter, Actinomyces, Exiguobacterium, Kocuria, Micrococcus, Rothia, Rhodococcus and classified numerically using a set of 52 phenetic characteristics, using simple matching coefficient （Ssm） and clustering method of unweighted average linkage between groups by SPSS program. They were also grouped to 7 main clusters and 29 sub-clusters in the hierarchical tree. Twelve isolates of the different species from the genera Brevibacterium, Arthrobacter, Corynebacterium, Kocuria, Rhodococcus, Rothia were selected from the taxonomic clusters and probed for lin gene by peR. One species Kocuria rhizophila which inhibited most of the test organism did not have lin gene in the chromosome while the species Corynebacterium glucuronolyticum, Arthrobacter comminsii, Arthrobacter oxydans have the lin gene. Our results establish a wide distribution of the structural gene encoding this Iinocin M 18 within coryneform bacteria and also in the genus Kocuria.展开更多
Rather than random degradation products, the 18 to 40 nucleotides(nt) transfer RNA-derived small RNAs(tsRNAs) are RNA species generated specifically from pre-RNAs or mature tRNAs in archaea, bacteria and eukaryotes. R...Rather than random degradation products, the 18 to 40 nucleotides(nt) transfer RNA-derived small RNAs(tsRNAs) are RNA species generated specifically from pre-RNAs or mature tRNAs in archaea, bacteria and eukaryotes. Recent studies from animal systems have shown that tsRNAs are important non-coding RNAs that regulate gene expression at the transcriptional and/or post-transcriptional levels. They are involved in various biological processes, such as cell proliferation, tumor genesis, stress response and intergenerational epigenetic inheritance. In this review, we will summarize the discovery, biogenesis, and function of tsRNAs in higher plants. In addition, analysis on tsRNAs from lower plants is shown.展开更多
文摘细菌非编码小RNA（non-coding small RNA,简称sRNA）是一类长度为40~500个核苷酸,在基因组中被转录但不编码蛋白质的一类RNA分子。它们大多数在Hfq的协助下,通过碱基配对识别靶标mRNA,在转录后水平调节基因的表达,是细菌代谢、群体感应和适应环境变化及毒力基因表达的重要调节因子。本文对sRNA的分类及功能作如下综述。
文摘Fifty bacterial strains isolated from dairy product, skin and blood from cancer and kidney failure dialysis patients were identified to 22 species and the following genera： Brevibacterium, Corynebacterium, Arthrobacter, Actinomyces, Exiguobacterium, Kocuria, Micrococcus, Rothia, Rhodococcus and classified numerically using a set of 52 phenetic characteristics, using simple matching coefficient （Ssm） and clustering method of unweighted average linkage between groups by SPSS program. They were also grouped to 7 main clusters and 29 sub-clusters in the hierarchical tree. Twelve isolates of the different species from the genera Brevibacterium, Arthrobacter, Corynebacterium, Kocuria, Rhodococcus, Rothia were selected from the taxonomic clusters and probed for lin gene by peR. One species Kocuria rhizophila which inhibited most of the test organism did not have lin gene in the chromosome while the species Corynebacterium glucuronolyticum, Arthrobacter comminsii, Arthrobacter oxydans have the lin gene. Our results establish a wide distribution of the structural gene encoding this Iinocin M 18 within coryneform bacteria and also in the genus Kocuria.
基金supported by the General Program of National Natural Science Foundation of China (31471165 to Zhicheng Dong)
文摘Rather than random degradation products, the 18 to 40 nucleotides(nt) transfer RNA-derived small RNAs(tsRNAs) are RNA species generated specifically from pre-RNAs or mature tRNAs in archaea, bacteria and eukaryotes. Recent studies from animal systems have shown that tsRNAs are important non-coding RNAs that regulate gene expression at the transcriptional and/or post-transcriptional levels. They are involved in various biological processes, such as cell proliferation, tumor genesis, stress response and intergenerational epigenetic inheritance. In this review, we will summarize the discovery, biogenesis, and function of tsRNAs in higher plants. In addition, analysis on tsRNAs from lower plants is shown.
