期刊文献+
共找到5篇文章
< 1 >
每页显示 20 50 100
激动素通过抑制纤溶酶原激活物抑制因子1减轻博莱霉素诱导的大鼠肺纤维化 被引量:2
1
作者 王欣燕 黄坤 +3 位作者 康小文 李兆国 阳成成 吴晓梅 《中国呼吸与危重监护杂志》 CAS 2014年第1期44-48,共5页
目的研究激动素对博莱霉素A5(BLM-A5)诱导的大鼠肺纤维化的干预作用。方法雌性Wistar大鼠60只随机分为对照组、模型组和治疗组,每组20只。模型组与治疗组大鼠经穿刺向气管内注入BLM-A5(5 mg/kg),对照组在相同条件下注入等体积生理盐水... 目的研究激动素对博莱霉素A5(BLM-A5)诱导的大鼠肺纤维化的干预作用。方法雌性Wistar大鼠60只随机分为对照组、模型组和治疗组,每组20只。模型组与治疗组大鼠经穿刺向气管内注入BLM-A5(5 mg/kg),对照组在相同条件下注入等体积生理盐水。治疗组于灌注BLM-A5的第1 d开始腹腔注入0.5%激动素(0.5 mL/100 g),每日1次。分别于第3、7、14、28 d处死大鼠,取肺组织病理切片行HE及Masson染色观察肺部炎症和纤维化情况,ELISA方法检测肺组织羟脯氨酸(HYP)含量及肺组织和血浆中尿激酶型纤溶酶原激活物(u-PA)、组织型纤溶酶原激活物(t-PA)、PAI-1含量。结果模型组第7 d肺泡炎最明显,到28 d时肺纤维化最严重;治疗组肺泡炎及肺纤维化程度均较模型组显著减轻,但仍较对照组严重(P<0.05)。模型组第7 d时HYP含量开始升高,28 d最高;各组变化趋势与肺纤维化变化相一致。模型组肺组织u-PA在第3 d开始下降,至7 d时最低,14 d仍显著低于其他两组(P<0.05),28 d时三组间无明显差异(P>0.05)。模型组血浆u-PA水平在第3 d开始下降,至7 d时最低,与其他两组比较有显著差异(P<0.05),14 d后三组之间无明显差异(P>0.05)。三组t-PA在肺组织和血浆中的含量变化与u-PA基本一致,但在14 d时模型组血浆t-PA含量仍较对照组显著降低(P<0.05)。模型组肺组织PAI-1在第3 d开始升高,至7 d时最高,14 d时仍显著高于其他两组(P<0.05),28 d时三组之间无明显差异(P>0.05);治疗组肺组织PAI-1水平较模型组下降(P<0.05),但仍高于对照组(P<0.05),至14 d时无显著差异(P>0.05)。模型组血浆PAI-1在第3 d开始升高,至7 d时最高,显著高于其他两组(P<0.05),但14 d后三组间无明显差异(P>0.05)。结论激动素通过抑制肺组织PAI-1生成,使u-PA、t-PA含量升高,减轻了博莱霉素A5所致的大鼠肺纤维化。 展开更多
关键词 维化 激动素 酶原激活物抑制物1 尿激酶酶原激活物 织型纤溶酶原激活物
原文传递
An Experimental Study of Pathogenesis of Steroid-induced Avascular Necrosis of Femoral Head 被引量:1
2
作者 李毅 陈君长 +3 位作者 康斌 王坤正 张珍妮 同志超 《Journal of Nanjing Medical University》 2003年第4期191-195,共5页
Objective: To explore the pathogenesis of avascular necrosis of femoral head(ANFH) and search an effective method for clinical practice. Methods: Twenty-four Japanese rabbitswere divided into 2 groups of models and co... Objective: To explore the pathogenesis of avascular necrosis of femoral head(ANFH) and search an effective method for clinical practice. Methods: Twenty-four Japanese rabbitswere divided into 2 groups of models and controls. ANFH models were produced byintramuscular-injection of large dosage of steroid to rabbits for 8 weeks. From the 4th, 8th and12th week after production of models, 2 rabbits of each group were sacrificed to observe thestructure of femoral head through light microscope and scanning electron microscope. The contents ofNitric Oxide (NO), tissue-type plasminogen activator (t-PA) and -plasminogen activator inhibitor(PAI) in plasma of the 4 rabbits in each group were estimated at the same time. Results: Comparedwith control group, the rabbits of model group exhibited many differences: such as osteoporosis offemoral head, the presence of more bone lacuna and fat cell through light microscope observing; thebroken and sunk bone trabecula, the loosen and broken collagen fibers on the surface of bone matrixthrough scanning electron microscope observing. Compared with control group, the Concentration ofNO and t-PA in plasma of the model rabbits decreased obviously, but the Concentration of the PAIincreased obviously. Conclusion: The steroid-induced ANFH might be related to the lower level of NOand the descent of fibrinolytic activity. 展开更多
关键词 femoral head necrosis pathological process nitric oxide tissue-typeplasminogen activator plasminogen activator inhibitor
下载PDF
The Role of Tissue-type Plasminogen Activator in Rat Corpus Luteum 被引量:2
3
作者 陈亚雄 陈宜峰 刘以训 《Developmental and Reproductive Biology》 1993年第1期28-32,共5页
It is here reported for the first time that luteal cells are capable of secreting plasminogen activators(PA),(both tissue-type,tPA,and urokinase-type,uPA),and plasminogen activator inhibitor type-1(PAl-1).Using organ ... It is here reported for the first time that luteal cells are capable of secreting plasminogen activators(PA),(both tissue-type,tPA,and urokinase-type,uPA),and plasminogen activator inhibitor type-1(PAl-1).Using organ culture model,we have demonstrated that tPA,but not uPA,showed markedchange during luteolytic period in rat corpus luteum.A great amount oftPA was secreted in corpusluteum on D 14 and D 17 while very low level of tPA activity was detected before D 12.Correspondingly,the progesterone production in the corpus luteum increased gradually in a time-dependent manner from D 1 to D 12 but dropped abruptly to a very low level on D 14.Additionof exogenous tPA to the CL culture caused considerable decrease in progesterone secretion whileinclusion of purified monoclone tPA antibodies in the culture augmented progesterone productionof CL.It is therefore suggested that tPA may play an important role in luteolytic process. 展开更多
关键词 Tissue-type plasminogen activator PROGESTERONE LUTEOLYSIS
下载PDF
Clinical significance of plasma tissue factor pathway and urokinase-type plasminogen activator system in cancer patients 被引量:1
4
作者 赵维莅 王学锋 +2 位作者 璩斌 黄霞萍 王鸿利 《Chinese Medical Journal》 SCIE CAS CSCD 2002年第5期702-704,150,共3页
OBJECTIVE: To evaluate variations in the plasma tissue factor (TF) and urokinase type plasminogen activator (u-PA) system and their relationship with clinical cancer type, pathological classification and metastatic st... OBJECTIVE: To evaluate variations in the plasma tissue factor (TF) and urokinase type plasminogen activator (u-PA) system and their relationship with clinical cancer type, pathological classification and metastatic status in cancer patients. METHODS: Plasma levels of TF and its inhibitor (TFPI), as well as u-PA and its receptor (u-PAR) were measured using ELISA in 76 patients with malignant tumors and 24 patients with benign tumors. RESULTS: Plasma levels of TF and u-PAR in the malignant tumor group were significantly higher than those of the benign tumor group and the normal control. U-PA and u-PAR increased significantly in patients with esophageal and gastric cancer. However, most of these parameters except TFPI did not vary according to pathological classification. A significant elevation was evident in patients with local infiltration, lymph node involvement and distal metastasis, while u-PAR only increased in the latter two categories. CONCLUSIONS: Both the TF and u-PA systems are activated in cancer patients. U-PA and its receptor might prove to be a clinically useful marker for disease progression. 展开更多
关键词 ADULT Aged Aged 80 and over Female Humans LIPOPROTEINS Male Middle Aged Neoplasm Metastasis NEOPLASMS Receptors Cell Surface Research Support Non-U.S. Gov't THROMBOPLASTIN Urinary Plasminogen Activator
原文传递
中西医结合治疗脑梗死急性期临床分析
5
作者 马亮 《中文科技期刊数据库(全文版)医药卫生》 2022年第2期169-172,共4页
深入分析中西医结合治疗脑梗死急性期的临床效果。方法:挑选本医院内2018年6月-2021年3月收纳的96例脑梗死急性期病人当作此次的分析对象,依据Excel函数法把其随机划分成2组,对照组施加常规西医治疗,实验组施加中西医结合治疗,比较2组... 深入分析中西医结合治疗脑梗死急性期的临床效果。方法:挑选本医院内2018年6月-2021年3月收纳的96例脑梗死急性期病人当作此次的分析对象,依据Excel函数法把其随机划分成2组,对照组施加常规西医治疗,实验组施加中西医结合治疗,比较2组病人的临床治疗效果。结果:实验组治疗有效率、ADL评分均明显超过了对照组,肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、C反应蛋白(CRP)水平和NIHSS评分都明显小于对照组,凝血功能指标、组织型纤溶酶原激活物(t-PA)、抑制物(PAI)水平显著优于对照组,P<0.05。结论:中西医结合治疗脑梗死急性期的临床效果明显。所以,在对脑梗死急性期病人进行治疗的过程中最好及时把中西医结合治疗法普遍应用在其中,推动治疗质量、治疗效率等均持续提高。 展开更多
关键词 脑梗死急性期 凝血功能指标 NIHSS评分 ADL评分 织型纤溶酶原激活物
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部