Defect detection is vital in the nonwoven material industry,ensuring surface quality before producing finished products.Recently,deep learning and computer vision advancements have revolutionized defect detection,maki...Defect detection is vital in the nonwoven material industry,ensuring surface quality before producing finished products.Recently,deep learning and computer vision advancements have revolutionized defect detection,making it a widely adopted approach in various industrial fields.This paper mainly studied the defect detection method for nonwoven materials based on the improved Nano Det-Plus model.Using the constructed samples of defects in nonwoven materials as the research objects,transfer learning experiments were conducted based on the Nano DetPlus object detection framework.Within this framework,the Backbone,path aggregation feature pyramid network(PAFPN)and Head network models were compared and trained through a process of freezing,with the ultimate aim of bolstering the model's feature extraction abilities and elevating detection accuracy.The half-precision quantization method was used to optimize the model after transfer learning experiments,reducing model weights and computational complexity to improve the detection speed.Performance comparisons were conducted between the improved model and the original Nano Det-Plus model,YOLO,SSD and other common industrial defect detection algorithms,validating that the improved methods based on transfer learning and semi-precision quantization enabled the model to meet the practical requirements of industrial production.展开更多
Objective: To investigate the expression and clinical significance of Fas andFasL in lung cancer. Methods: SP immunohistochemical technique was used to detect the expression ofFas and FasL in 46 cases of lung cancer a...Objective: To investigate the expression and clinical significance of Fas andFasL in lung cancer. Methods: SP immunohistochemical technique was used to detect the expression ofFas and FasL in 46 cases of lung cancer and 30 cases of adjacent non-neoplastic tissue. Results:Down-regulation, of Fas and up-regulation of FasL were found in lung carcinoma. The levels of Fasexpression in squamous cell carcinoma, adenocarcinoma and SCLC were significantly lower than that ofadjacent normal tissues (P<0. 01) , while the expression levels of FasL were the opposite (P< 0.05). Fas expression was associated with high histological grade and no metastasis (P<0. 05). FasLexpression was related to histological grade, late clinical stage and metastasis (P<0. 05). BothFas and FasL expression was not related to the histological type of lung cancer (P>0. 05). Thelevel of Fas expression was negatively related to that of FasL (P<0. 05). Conclusion:Down-regulation of Fas and up-regulation of FasL may work in coordination with the occurrence,development and metastasis of lung cancer. Fas or FasL can be used as one of markers in earlydiagnosis of lung cancer. Therefore, the combined assay may be helpful in predicting the grade ofmalignancy and the prognosis of patients with lung cancer.展开更多
An access control model is proposed based on the famous Bell-LaPadula (BLP) model.In the proposed model,hierarchical relationships among departments are built,a new concept named post is proposed,and assigning secur...An access control model is proposed based on the famous Bell-LaPadula (BLP) model.In the proposed model,hierarchical relationships among departments are built,a new concept named post is proposed,and assigning security tags to subjects and objects is greatly simplified.The interoperation among different departments is implemented through assigning multiple security tags to one post, and the more departments are closed on the organization tree,the more secret objects can be exchanged by the staff of the departments.The access control matrices of the department,post and staff are defined.By using the three access control matrices,a multi granularity and flexible discretionary access control policy is implemented.The outstanding merit of the BLP model is inherited,and the new model can guarantee that all the information flow is under control.Finally,our study shows that compared to the BLP model,the proposed model is more flexible.展开更多
Schistosomal appendicitis is very rare in developed countries like the USA,Europe,and Japan.The author reviewed 311 pathologic archival specimens of vermiform appendix over the past 10 years.One case of schistosomal a...Schistosomal appendicitis is very rare in developed countries like the USA,Europe,and Japan.The author reviewed 311 pathologic archival specimens of vermiform appendix over the past 10 years.One case of schistosomal appendicitis was recognized.Therefore,the incidence of this disease was 0.32% in all appendices surgically resected in our hospital.The patient was a 41-year-old woman presenting with lower abdominal pain.She was a sailor traveling to many countries including endemic areas.Physical examination,laboratory data,and imaging modalities suggested an acute appendicitis,and appendectomy was performed under the diagnosis of ordinary appendicitis.Histologically,numerous schistosomal eggs were present in the vasculatures throughout the appendiceal walls.Some of the eggs were calcified.Stromal foreign body reaction was also recognized.The appendicitis was phlegmonous consisting of severe infiltrations of neutrophils and eosinophils.Acute serositis was also noted.Examination of feces revealed numerous eggs of Schistosoma mansoni.Clinicians should be aware of schistosomal appendicitis.展开更多
Objective: The expression of tumor biomarkers may change after chemotherapy. However, whether secreted protein acidic and rich in cysteine (SPARC) expression changes after chemotherapy in gastric cancer (GC) is u...Objective: The expression of tumor biomarkers may change after chemotherapy. However, whether secreted protein acidic and rich in cysteine (SPARC) expression changes after chemotherapy in gastric cancer (GC) is unclear, qqais study investigated the influence of chemotherapy on SPARC expression in GC. Methods: Immunohistochemistry was used to analyze SPARC expression in 132 GC cases (including 54 cases with preoperative chemotherapy and 78 cases without preoperative chemotherapy). SPARC expression of postoperative specimens with and without preoperative chemotherapy was assessed to analyze the influence of chemotherapy on SPARC expression. Results: SPARC was highly expressed in GC compared with the desmoplastic stroma surrounding tumor cells and noncancerous tissues. High SPAKC expression was correlated with invasion depth, lymph node, and TNM stage. After chemotherapy, a lower proportion of high SPARC expression was observed in patients with preoperative chemotherapy than in the controls. For 54 patients with preoperative chemotherapy; gross type, histology, depth of invasion, lymph node, TNM stage, and SPARC expression were related to overall survival. Further multivariate analysis showed that lymph node, histology, and SPARC expression after chemotherapy were independent prognostic factors. Conclusiou: SPARC expression may change after chemotherapy in GC. SPARC expression should be reassessed for patients with GC after chemotherapy.展开更多
Objective To evaluate the sensitivity and specificity of international classification criteria (2002) for primary Sjogren's syndrome (pSS) and the role of lower lip biopsy in diagnosis of pSS in Chinese patients....Objective To evaluate the sensitivity and specificity of international classification criteria (2002) for primary Sjogren's syndrome (pSS) and the role of lower lip biopsy in diagnosis of pSS in Chinese patients. Mothoda Patients who were diagnosed by the experts/rheumatologists as pSS during 1990-2002 from the Department of Rheumatology, Peking Union Medical College Hospital were retrospectively collected as experimental group. Patients who were diagnosed as non-pSS connective tissue diseases or non-connective tissue diseases served as control group. Those with a history of head-neck radiation, hepatitis C virus infection, AIDS, lymphoma, sarcoidosis, graft versus host disease (GVHD), and anti-acetylcholine drug use were exempted. Both groups were required to complete questionnaires about symptoms such as dry eyes and dry mouth, and complete the objective tests of keratoconjunctivitis and xerostomia including Schirmer test, corneal staining, unstimulated salivary flow, sialography, lower lip biopsy, and antinuclear antibodies (including anti-SSA/SSB antibodies) test. Results A total of 330 pSS patients were included in experimental group and 185 non-pSS patients in control group. The mean age of both groups matched (47.8 ± 10.9 years vs. 46.2±13.6 years, P 〉 0.05). The sensitivities of the criteria in pSS patients with lower lip biopsy and in pSS patients without lower lip biopsy were 89.2% and 87.2%, respectively; the overall sensitivity was 88.5%. The specificity was 97.3%. A total of 11.3% pSS patients with negative anti-SSA/SSB antibodies were diagnosed as pSS by lower lip biopsy. Coadwion The international classification criteria (2002) for pSS is feasible in Chinese patients. It has high sensitivity and specificity, and may serve as diagnosis criteria in routine clinical practice.展开更多
AIM: To investigate the reliability of massive hepatectomy models by using clip techniques. METHODS: We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70%. The i...AIM: To investigate the reliability of massive hepatectomy models by using clip techniques. METHODS: We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70%. The impact of various factors in the different models was also analyzed, including learning curves, operative time, survival curves, and histopathological findings.RESULTS: According to anatomical results, models with 75%, 80%, and 90% hepatectomy produced massive hepatectomy. Learning curves and operative times were most optimal with the clip technique. Each hepatectomy performed using the clip technique produced a reasonable survival curve, and there were no differences in histopathological findings between the suture and clip techniques. CONCLUSION: Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data.展开更多
To evaluate gambiered Guangdong silk's ecology properties, the raw materials ecology, production ecology and use ecology are analyzed; and the safety to human is tested according to GB/T18885 - 2002. Gambiered Guangd...To evaluate gambiered Guangdong silk's ecology properties, the raw materials ecology, production ecology and use ecology are analyzed; and the safety to human is tested according to GB/T18885 - 2002. Gambiered Guangdong silk is a kind of natural product. All its raw materials are reproducible and degradable natural resources, and it can decompose completely when being discarded. R is comfortable to wear, and easy to clean and dry. It is mainly manufactured by dip-dyeing in dye yam solution, and insolating under the burning sun. The production energy is solar, a kind of clean and reproducible energy. The production process is clean and environmental friendly. There is neither the utilization of synthetic dyestuff and chemical auxiliary, nor the discharge of environment pollutant, and even the dreg of dye yam is used as fuel. The safety test results show that pH value of water extract, heavy metal content (except for Pb content), color fastness and odor meet the requirements of GB/T18885 - 2002 and Okeo-tex standard 100.展开更多
Chronic liver diseases are very common worldwide, particularly those linked to viral hepatitis and to alcoholic and non-alcoholic fatty liver. Their natural history is variable and long-term evolution differs in indiv...Chronic liver diseases are very common worldwide, particularly those linked to viral hepatitis and to alcoholic and non-alcoholic fatty liver. Their natural history is variable and long-term evolution differs in individual patients. Optimised clinical management of compensated chronic liver diseases requires precise definition of the stage of liver fibrosis, the main determinant of prognosis and of most therapeutic decisions. Liver biopsy is the gold standard for assessment of hepatic fibrosis. However, it is invasive with possible complications, costly and prone to sampling errors. Many non-invasive markers of liver fibrosis have been recently proposed and assessed in the clinical setting as surrogates of liver biopsy. Direct markers are based on biochemical parameters directly linked to fibrogenesis while indirect markers use simple or more sophisticated parameters that correlate with liver fibrosis stages. Non-invasive markers of liver fibrosis have been tested in different forms of chronic liver disease and showed variable diagnostic performance, but accuracy rarely was above 75%-80%. Better results were obtained when markers were combined. On this line, we have recently proposed a set of algorithms that combine sequentially indirect non-invasive markers of liver fibrosis, reaching 90%-95% diagnostic accuracy with significant reduction in the need for liver biopsy. Based on available evidence, it can be anticipated that non-invasive markers of liver fibrosis and their combined use will soon become a most useful tool in the clinical management of many forms of chronic liver disease. However, their implementation is expected to reduce, but not to completely eliminate, the need for liver biopsy.展开更多
Objective:To assess the diagnostic accuracy of whole-body MRI using diffusion-weighted sequence(WB-DWI)to determine the peritoneal cancer index(PCI)in correlation with surgical and histopathological findings.Meth...Objective:To assess the diagnostic accuracy of whole-body MRI using diffusion-weighted sequence(WB-DWI)to determine the peritoneal cancer index(PCI)in correlation with surgical and histopathological findings.Methods:Twenty-seven patients underwent preoperative WB-MRI,followed by cytoreductive surgery for primary tumors of the appendix(n=15),colorectum(n=12),and associated peritoneal disease.A total of 351 regions were retrospectively reviewed.The sensitivity,specificity,and accuracy were calculated at 13 anatomical sites.The WB-DWI PCI and PCI type were compared with surgical and histopathological findings.Results:No statistical difference was found between the WB-DWI PCI and surgical PCI(P=0.574).WB-DWI correctly predicted the PCI type in 24 of 27 patients with high accuracy(88.9%),including 10 of 10 patients with small-volume tumor,12 of 14 with moderate-volume tumor,and 2 of 3 with large-volume tumor.WB-DWI correctly depicted tumors in 163 of 203 regions,with 40false-negative and 23 false-positive regions.The overall sensitivity,specificity,and accuracy of WB-DWI for the detection of peritoneal tumors were 80.3%,84.5%,and 82.1%,respectively.For lesions&lt;0.5 cm in diameter,WB-DWI demonstrated good sensitivity(69.4%).Conclusions:WB-DWI accurately predicted PCI before surgery in patients undergoing evaluation for cytoreductive surgery.展开更多
Abstract: Estimation of evapotranspiration (ET) for mountain ecosystem is of absolute importance since it serves as an important component in balancing the hydrologic cycle. The present study evaluates the performa...Abstract: Estimation of evapotranspiration (ET) for mountain ecosystem is of absolute importance since it serves as an important component in balancing the hydrologic cycle. The present study evaluates the performance of original and location specific calibrated Hargreaves equation (HARG) with the estimates of Food and Agricultural Organization (FAO) Penman Monteith (PM) method for higher altitudes in East Sikkim, India. The results show that the uncalibrated HARG model underestimates ET0 by 0.35 mm day^-1 whereas the results are significantly improved by regional calibration of the model. In addition, this paper also presents the variability in the trajectory associated with the climatic variables with the changing climate in the study site. Non- parametric Mann-Kendall (MK) test was used to investigate and understand the mean monthly trend of eight climatic parameters including reference evapotranspiration (ET0) for the period of 1985 - 2009. Trend of ET0 was estimated for the calculations done by FAO PM equation. The outcomes of the trend analysis show significant increasing (p ≤ 0.05) trend represented by higher Z-values, through MK test, for net radiation (Rn), maximum temperature (Tmax) and minimum temperature (Train), especially in the first months of the year. Whereas, significant (0.01 ≥ p ≤0.05) decreasing trend in vapor pressure deficit (VPD) and precipitation (P) is observed throughout the year. Declining trend in sunshine duration, VPD and ET0 is found in spring (March - May) and monsoon (June - November) season. The result displays significant (0.01≤ p ≤0.05) decreasing ET0 trend between (June - December) except in July, exhibiting the positive relation with VPD followed by sunshine duration at the station. Overall, the study emphasizes the importance of trend analysis of ET0 and other climatic variables for efficient planning and managing the agricultural practices, in identifying the changes in the meteorological parameters and to accurately assess the hydrologic water balance of the hilly regions.展开更多
AIM:To investigate the expression and potential prognostic role of vascular endothelial growth factor(VEGF) and endoglin in gastroenteropancreatic neuroendocrine tumors(GEP-NETs) . METHODS:Microvessel density(MVD) in ...AIM:To investigate the expression and potential prognostic role of vascular endothelial growth factor(VEGF) and endoglin in gastroenteropancreatic neuroendocrine tumors(GEP-NETs) . METHODS:Microvessel density(MVD) in GEP-NETs was evaluated using endoglin and CD31 immunohistochemistry.In addition,tissue levels of endoglin and VEGF were determined in homogenates by ELISA. RESULTS:Endoglin was highly expressed on tumor endothelial cells.CD31 MVD in GEP-NETs was significantly higher compared to endoglin MVD(P<0.01) .Two-tofour-fold higher tissue levels of endoglin and VEGF were seen in tumors compared to associated normal tissue. This increased endoglin tissue expression in tumors was significantly related to tumor size(P<0.01) ,presence of metastases(P=0.04) ,and a more advanced tumor stage(P=0.02) ,whereas expression of VEGF was not. CONCLUSION:We suggest that endoglin is a potential marker to indicate and predict metastases,which might be useful in the post-resection therapeutic approach of patients with GEP-NETs.展开更多
Hepatocellular carcinoma(HCC) remains one of the major public health problems throughout the world.Although originally associated with tumorigenic processes,liver angiogenesis has also been observed in the context of ...Hepatocellular carcinoma(HCC) remains one of the major public health problems throughout the world.Although originally associated with tumorigenic processes,liver angiogenesis has also been observed in the context of different liver in-flammatory,fibrotic,and ischemic conditions.Here we investigate the fractal dimension as a quantitator of non-Euclidean two-dimensional vascular geometry in a series of paired specimens of primary HCC and surrounding non-tumoral tissue,and discuss why this parameter might provide additional information regarding cancer behavior.The application of fractal geometry to the measurement of liver vascularity and the availability of a computer-aided quantitative method can eliminate errors in visual interpretation,and make it possible to obtain closer-to-reality numerals that are compulsory for any measurement process.展开更多
The purpose of this paper is to investigate reasonable cost benefit criteria within the framework of environmental formal safety assessment (FSA). In this study a statistical analysis of oil spill data was carried o...The purpose of this paper is to investigate reasonable cost benefit criteria within the framework of environmental formal safety assessment (FSA). In this study a statistical analysis of oil spill data was carried out based on the report of International Oil Pollution Compensation Funds. According to the statistical study of actual oil spill from tankers, it is found that collisions and groundings are the most probable causes of the oil spills from tankers. Probability distributions of costs of oil spill and oil spill amount are investigated, and a non-linear regression formula between costs of oil spills and oil spill weight are derived. Using the regression formula, an oil spill weight dependent CATStm (Cost of Averting a Ton of oil Spilt) is proposed. Moreover in order to apply the weight dependent CATSthr to cost benefit analysis (CBA), a new cost-effective criterion is newly proposed with considering its concrete application to environmental FSA.展开更多
As an open standard of data representation,XML breathes new energy to the Web application and the network computing.The development,advantage and status of XML and some standards relating to XML are reviewed.In additi...As an open standard of data representation,XML breathes new energy to the Web application and the network computing.The development,advantage and status of XML and some standards relating to XML are reviewed.In addition,the authors put forward a method representing logging data and using UML language to establish the conceptual and logical model of logging data;using a logging data,explain how to establish the model as well as how to use XML to display and process geology data.展开更多
Co-occurrence matrices have been successfully applied in texture classification and segmentation.However,they have poor computation performance in real-time application.In this paper,the efficient co-occurrence matrix...Co-occurrence matrices have been successfully applied in texture classification and segmentation.However,they have poor computation performance in real-time application.In this paper,the efficient co-occurrence matrix solution for defect detection is focused on,and a method of Fuzzy Label Co-occurrence Matrix (FLCM) set is proposed.In this method,all gray levels are supposed to subject to some fuzzy sets called fuzzy tonal sets and three defective features are defined.Features of FLCM set with various parameters are combined for the final judgment.Unlike many methods,image acquired for learning hasn't to be entirely free of defects.It is shown that the method produces high accuracy and can be a competent candidate for plain colour fabric defect detection.展开更多
Objective To evaluate the epicardial fat tissue thickness (EFTT) as a diagnostic criterion for geriatric patients with metabolic syn- drome (MetS). Methods Sixty geriatric patients over 65 years of age were recrui...Objective To evaluate the epicardial fat tissue thickness (EFTT) as a diagnostic criterion for geriatric patients with metabolic syn- drome (MetS). Methods Sixty geriatric patients over 65 years of age were recruited for the study. Patients were divided into two groups: Group 1 (n = 30) consisted of patients with MetS; Group 2 (n = 30) consisted of patients without MetS. Echocardiography was used to measure EFTT in all patients, and blood samples were analyzed for biochemical parameters. Results Compared to Group 2, EFTT levels of Group 1 were statistically higher (P 〈 0.05). In a binary logistic regression analysis, EFTT levels served as the independent factor for meta- bolic syndrome 03 = 17.35, SE = 4.93, Wald = 12.36, P 〈 0.001). Receivers operating characteristic Curve (ROC-curve) analysis revealed that EFTT predicted MetS with 96.7% sensitivity and 86.7% specificity above the level of 7.3 mm [area under the curve = 0.969; 95% con- fidence interval (CI): 0.928-1.00]. Conclusions The present study demonstrated that serum EFTT levels were higher in geriatric patients with MetS and can therefore be used as a diagnostic criterion for MetS.展开更多
AIM:To establish an appropriate primate model of fulminant hepatic failure (FHF).METHODS:We have,for the first time,established a large animal model of FHF in Macaca mulatta by intraperitoneal infusion of amatoxin and...AIM:To establish an appropriate primate model of fulminant hepatic failure (FHF).METHODS:We have,for the first time,established a large animal model of FHF in Macaca mulatta by intraperitoneal infusion of amatoxin and endotoxin.Clinical features,biochemical indexes,histopathology and iconography were examined to dynamically investigate the progress and outcome of the animal model.RESULTS:Our results showed that the enzymes and serum bilirubin were markedly increased and the enzyme-bilirubin segregation emerged 36 h after toxin administration.Coagulation activity was significantly decreased.Gradually deteriorated parenchymal abnormality was detected by magnetic resonance imaging (MRI) and ultrasonography at 48 h.The liver biopsy showed marked hepatocyte steatosis and massive parenchymal necrosis at 36 h and 49 h,respectively.The autopsy showed typical yellow atrophy of the liver.Hepatic encephalopathy of the models was also confirmed by hepatic coma,MRI and pathological changes of cerebral edema.The lethal effects of the extrahepatic organ dysfunction were ruled out by their biochemical indices,imaging and histopathology.CONCLUSION:We have established an appropriate large primate model of FHF,which is closely similar to clinic cases,and can be used for investigation of the mechanism of FHF and for evaluation of potential medical therapies.展开更多
Nowadays, there exist various standards for individual management systems (MSs), at least, one for each stakeholder. New ones will be published. An integrated management system (IMS) aims to integrate some or all ...Nowadays, there exist various standards for individual management systems (MSs), at least, one for each stakeholder. New ones will be published. An integrated management system (IMS) aims to integrate some or all components of the business into one coherent and efficient MS. Maximizing integration is more and more a strategic priority in that it constitutes an opportunity to eliminate and/or reduce potential factors of destruction of value for the organizations and also to be more competitive and consequently promote its sustainable success. A preliminary investigation was conducted on a Portuguese industrial company which, over the years, has been adopting gradually, in whole or in part, individualized management system standards (MSSs). A research, through a questionnaire, was performed with the objective to develop, in a real business environment, an adequate and efficient IMS-QES (quality, environment, and safety) model and to potentiate for the future a generic IMS model to integrate other MSSs. The strategy and research methods have taken into consideration the case study. It was obtained a set of relevant conclusions resulting from the statistical analyses of the responses to the survey. Globally, the investigation results, by themselves, justified and prioritized the conception of a model of development of the IMS-QES and consequent definition and validation of a structure of an IMS-QES model, to be implemented at the small- and medium-sized enterprise (SME) where the investigation was conducted.展开更多
基金National Key Research and Development Program of China(Nos.2022YFB4700600 and 2022YFB4700605)National Natural Science Foundation of China(Nos.61771123 and 62171116)+1 种基金Fundamental Research Funds for the Central UniversitiesGraduate Student Innovation Fund of Donghua University,China(No.CUSF-DH-D-2022044)。
文摘Defect detection is vital in the nonwoven material industry,ensuring surface quality before producing finished products.Recently,deep learning and computer vision advancements have revolutionized defect detection,making it a widely adopted approach in various industrial fields.This paper mainly studied the defect detection method for nonwoven materials based on the improved Nano Det-Plus model.Using the constructed samples of defects in nonwoven materials as the research objects,transfer learning experiments were conducted based on the Nano DetPlus object detection framework.Within this framework,the Backbone,path aggregation feature pyramid network(PAFPN)and Head network models were compared and trained through a process of freezing,with the ultimate aim of bolstering the model's feature extraction abilities and elevating detection accuracy.The half-precision quantization method was used to optimize the model after transfer learning experiments,reducing model weights and computational complexity to improve the detection speed.Performance comparisons were conducted between the improved model and the original Nano Det-Plus model,YOLO,SSD and other common industrial defect detection algorithms,validating that the improved methods based on transfer learning and semi-precision quantization enabled the model to meet the practical requirements of industrial production.
文摘Objective: To investigate the expression and clinical significance of Fas andFasL in lung cancer. Methods: SP immunohistochemical technique was used to detect the expression ofFas and FasL in 46 cases of lung cancer and 30 cases of adjacent non-neoplastic tissue. Results:Down-regulation, of Fas and up-regulation of FasL were found in lung carcinoma. The levels of Fasexpression in squamous cell carcinoma, adenocarcinoma and SCLC were significantly lower than that ofadjacent normal tissues (P<0. 01) , while the expression levels of FasL were the opposite (P< 0.05). Fas expression was associated with high histological grade and no metastasis (P<0. 05). FasLexpression was related to histological grade, late clinical stage and metastasis (P<0. 05). BothFas and FasL expression was not related to the histological type of lung cancer (P>0. 05). Thelevel of Fas expression was negatively related to that of FasL (P<0. 05). Conclusion:Down-regulation of Fas and up-regulation of FasL may work in coordination with the occurrence,development and metastasis of lung cancer. Fas or FasL can be used as one of markers in earlydiagnosis of lung cancer. Therefore, the combined assay may be helpful in predicting the grade ofmalignancy and the prognosis of patients with lung cancer.
基金The National Natural Science Foundation of China(No.60403027,60773191,70771043)the National High Technology Research and Development Program of China(863 Program)(No.2007AA01Z403)
文摘An access control model is proposed based on the famous Bell-LaPadula (BLP) model.In the proposed model,hierarchical relationships among departments are built,a new concept named post is proposed,and assigning security tags to subjects and objects is greatly simplified.The interoperation among different departments is implemented through assigning multiple security tags to one post, and the more departments are closed on the organization tree,the more secret objects can be exchanged by the staff of the departments.The access control matrices of the department,post and staff are defined.By using the three access control matrices,a multi granularity and flexible discretionary access control policy is implemented.The outstanding merit of the BLP model is inherited,and the new model can guarantee that all the information flow is under control.Finally,our study shows that compared to the BLP model,the proposed model is more flexible.
文摘Schistosomal appendicitis is very rare in developed countries like the USA,Europe,and Japan.The author reviewed 311 pathologic archival specimens of vermiform appendix over the past 10 years.One case of schistosomal appendicitis was recognized.Therefore,the incidence of this disease was 0.32% in all appendices surgically resected in our hospital.The patient was a 41-year-old woman presenting with lower abdominal pain.She was a sailor traveling to many countries including endemic areas.Physical examination,laboratory data,and imaging modalities suggested an acute appendicitis,and appendectomy was performed under the diagnosis of ordinary appendicitis.Histologically,numerous schistosomal eggs were present in the vasculatures throughout the appendiceal walls.Some of the eggs were calcified.Stromal foreign body reaction was also recognized.The appendicitis was phlegmonous consisting of severe infiltrations of neutrophils and eosinophils.Acute serositis was also noted.Examination of feces revealed numerous eggs of Schistosoma mansoni.Clinicians should be aware of schistosomal appendicitis.
文摘Objective: The expression of tumor biomarkers may change after chemotherapy. However, whether secreted protein acidic and rich in cysteine (SPARC) expression changes after chemotherapy in gastric cancer (GC) is unclear, qqais study investigated the influence of chemotherapy on SPARC expression in GC. Methods: Immunohistochemistry was used to analyze SPARC expression in 132 GC cases (including 54 cases with preoperative chemotherapy and 78 cases without preoperative chemotherapy). SPARC expression of postoperative specimens with and without preoperative chemotherapy was assessed to analyze the influence of chemotherapy on SPARC expression. Results: SPARC was highly expressed in GC compared with the desmoplastic stroma surrounding tumor cells and noncancerous tissues. High SPAKC expression was correlated with invasion depth, lymph node, and TNM stage. After chemotherapy, a lower proportion of high SPARC expression was observed in patients with preoperative chemotherapy than in the controls. For 54 patients with preoperative chemotherapy; gross type, histology, depth of invasion, lymph node, TNM stage, and SPARC expression were related to overall survival. Further multivariate analysis showed that lymph node, histology, and SPARC expression after chemotherapy were independent prognostic factors. Conclusiou: SPARC expression may change after chemotherapy in GC. SPARC expression should be reassessed for patients with GC after chemotherapy.
基金Supported by the National Natural Sciences Foundation of China(30300164 ).
文摘Objective To evaluate the sensitivity and specificity of international classification criteria (2002) for primary Sjogren's syndrome (pSS) and the role of lower lip biopsy in diagnosis of pSS in Chinese patients. Mothoda Patients who were diagnosed by the experts/rheumatologists as pSS during 1990-2002 from the Department of Rheumatology, Peking Union Medical College Hospital were retrospectively collected as experimental group. Patients who were diagnosed as non-pSS connective tissue diseases or non-connective tissue diseases served as control group. Those with a history of head-neck radiation, hepatitis C virus infection, AIDS, lymphoma, sarcoidosis, graft versus host disease (GVHD), and anti-acetylcholine drug use were exempted. Both groups were required to complete questionnaires about symptoms such as dry eyes and dry mouth, and complete the objective tests of keratoconjunctivitis and xerostomia including Schirmer test, corneal staining, unstimulated salivary flow, sialography, lower lip biopsy, and antinuclear antibodies (including anti-SSA/SSB antibodies) test. Results A total of 330 pSS patients were included in experimental group and 185 non-pSS patients in control group. The mean age of both groups matched (47.8 ± 10.9 years vs. 46.2±13.6 years, P 〉 0.05). The sensitivities of the criteria in pSS patients with lower lip biopsy and in pSS patients without lower lip biopsy were 89.2% and 87.2%, respectively; the overall sensitivity was 88.5%. The specificity was 97.3%. A total of 11.3% pSS patients with negative anti-SSA/SSB antibodies were diagnosed as pSS by lower lip biopsy. Coadwion The international classification criteria (2002) for pSS is feasible in Chinese patients. It has high sensitivity and specificity, and may serve as diagnosis criteria in routine clinical practice.
基金Supported by Grants to Justin H Nguyen from the Deason Foundation, Sandra and Eugene Davenport, Mayo Clinic CD CRT-II and NIH R01NS051646-01A2partial grant to Tomohide Hori from the Uehara Memorial Foundation, No. 200940051, Tokyo 171-0033, Japan
文摘AIM: To investigate the reliability of massive hepatectomy models by using clip techniques. METHODS: We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70%. The impact of various factors in the different models was also analyzed, including learning curves, operative time, survival curves, and histopathological findings.RESULTS: According to anatomical results, models with 75%, 80%, and 90% hepatectomy produced massive hepatectomy. Learning curves and operative times were most optimal with the clip technique. Each hepatectomy performed using the clip technique produced a reasonable survival curve, and there were no differences in histopathological findings between the suture and clip techniques. CONCLUSION: Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data.
基金Guangdong province science and technology plan project(No.2006B36401001)Guangzhou philosophy and social science planning program in 2005(No.YZ15-10)
文摘To evaluate gambiered Guangdong silk's ecology properties, the raw materials ecology, production ecology and use ecology are analyzed; and the safety to human is tested according to GB/T18885 - 2002. Gambiered Guangdong silk is a kind of natural product. All its raw materials are reproducible and degradable natural resources, and it can decompose completely when being discarded. R is comfortable to wear, and easy to clean and dry. It is mainly manufactured by dip-dyeing in dye yam solution, and insolating under the burning sun. The production energy is solar, a kind of clean and reproducible energy. The production process is clean and environmental friendly. There is neither the utilization of synthetic dyestuff and chemical auxiliary, nor the discharge of environment pollutant, and even the dreg of dye yam is used as fuel. The safety test results show that pH value of water extract, heavy metal content (except for Pb content), color fastness and odor meet the requirements of GB/T18885 - 2002 and Okeo-tex standard 100.
文摘Chronic liver diseases are very common worldwide, particularly those linked to viral hepatitis and to alcoholic and non-alcoholic fatty liver. Their natural history is variable and long-term evolution differs in individual patients. Optimised clinical management of compensated chronic liver diseases requires precise definition of the stage of liver fibrosis, the main determinant of prognosis and of most therapeutic decisions. Liver biopsy is the gold standard for assessment of hepatic fibrosis. However, it is invasive with possible complications, costly and prone to sampling errors. Many non-invasive markers of liver fibrosis have been recently proposed and assessed in the clinical setting as surrogates of liver biopsy. Direct markers are based on biochemical parameters directly linked to fibrogenesis while indirect markers use simple or more sophisticated parameters that correlate with liver fibrosis stages. Non-invasive markers of liver fibrosis have been tested in different forms of chronic liver disease and showed variable diagnostic performance, but accuracy rarely was above 75%-80%. Better results were obtained when markers were combined. On this line, we have recently proposed a set of algorithms that combine sequentially indirect non-invasive markers of liver fibrosis, reaching 90%-95% diagnostic accuracy with significant reduction in the need for liver biopsy. Based on available evidence, it can be anticipated that non-invasive markers of liver fibrosis and their combined use will soon become a most useful tool in the clinical management of many forms of chronic liver disease. However, their implementation is expected to reduce, but not to completely eliminate, the need for liver biopsy.
基金supported by the National Natural Science Foundation of China(Grant No.81501437)the Shanghai Municipal Planning Commission of Science and Research Fund(Grant No.JGGG1401)
文摘Objective:To assess the diagnostic accuracy of whole-body MRI using diffusion-weighted sequence(WB-DWI)to determine the peritoneal cancer index(PCI)in correlation with surgical and histopathological findings.Methods:Twenty-seven patients underwent preoperative WB-MRI,followed by cytoreductive surgery for primary tumors of the appendix(n=15),colorectum(n=12),and associated peritoneal disease.A total of 351 regions were retrospectively reviewed.The sensitivity,specificity,and accuracy were calculated at 13 anatomical sites.The WB-DWI PCI and PCI type were compared with surgical and histopathological findings.Results:No statistical difference was found between the WB-DWI PCI and surgical PCI(P=0.574).WB-DWI correctly predicted the PCI type in 24 of 27 patients with high accuracy(88.9%),including 10 of 10 patients with small-volume tumor,12 of 14 with moderate-volume tumor,and 2 of 3 with large-volume tumor.WB-DWI correctly depicted tumors in 163 of 203 regions,with 40false-negative and 23 false-positive regions.The overall sensitivity,specificity,and accuracy of WB-DWI for the detection of peritoneal tumors were 80.3%,84.5%,and 82.1%,respectively.For lesions&lt;0.5 cm in diameter,WB-DWI demonstrated good sensitivity(69.4%).Conclusions:WB-DWI accurately predicted PCI before surgery in patients undergoing evaluation for cytoreductive surgery.
文摘Abstract: Estimation of evapotranspiration (ET) for mountain ecosystem is of absolute importance since it serves as an important component in balancing the hydrologic cycle. The present study evaluates the performance of original and location specific calibrated Hargreaves equation (HARG) with the estimates of Food and Agricultural Organization (FAO) Penman Monteith (PM) method for higher altitudes in East Sikkim, India. The results show that the uncalibrated HARG model underestimates ET0 by 0.35 mm day^-1 whereas the results are significantly improved by regional calibration of the model. In addition, this paper also presents the variability in the trajectory associated with the climatic variables with the changing climate in the study site. Non- parametric Mann-Kendall (MK) test was used to investigate and understand the mean monthly trend of eight climatic parameters including reference evapotranspiration (ET0) for the period of 1985 - 2009. Trend of ET0 was estimated for the calculations done by FAO PM equation. The outcomes of the trend analysis show significant increasing (p ≤ 0.05) trend represented by higher Z-values, through MK test, for net radiation (Rn), maximum temperature (Tmax) and minimum temperature (Train), especially in the first months of the year. Whereas, significant (0.01 ≥ p ≤0.05) decreasing trend in vapor pressure deficit (VPD) and precipitation (P) is observed throughout the year. Declining trend in sunshine duration, VPD and ET0 is found in spring (March - May) and monsoon (June - November) season. The result displays significant (0.01≤ p ≤0.05) decreasing ET0 trend between (June - December) except in July, exhibiting the positive relation with VPD followed by sunshine duration at the station. Overall, the study emphasizes the importance of trend analysis of ET0 and other climatic variables for efficient planning and managing the agricultural practices, in identifying the changes in the meteorological parameters and to accurately assess the hydrologic water balance of the hilly regions.
基金Supported by Centre for Biomedical Genetics and Dutch Cancer Society RUL2005-3371(Hawinkels LJAC)
文摘AIM:To investigate the expression and potential prognostic role of vascular endothelial growth factor(VEGF) and endoglin in gastroenteropancreatic neuroendocrine tumors(GEP-NETs) . METHODS:Microvessel density(MVD) in GEP-NETs was evaluated using endoglin and CD31 immunohistochemistry.In addition,tissue levels of endoglin and VEGF were determined in homogenates by ELISA. RESULTS:Endoglin was highly expressed on tumor endothelial cells.CD31 MVD in GEP-NETs was significantly higher compared to endoglin MVD(P<0.01) .Two-tofour-fold higher tissue levels of endoglin and VEGF were seen in tumors compared to associated normal tissue. This increased endoglin tissue expression in tumors was significantly related to tumor size(P<0.01) ,presence of metastases(P=0.04) ,and a more advanced tumor stage(P=0.02) ,whereas expression of VEGF was not. CONCLUSION:We suggest that endoglin is a potential marker to indicate and predict metastases,which might be useful in the post-resection therapeutic approach of patients with GEP-NETs.
文摘Hepatocellular carcinoma(HCC) remains one of the major public health problems throughout the world.Although originally associated with tumorigenic processes,liver angiogenesis has also been observed in the context of different liver in-flammatory,fibrotic,and ischemic conditions.Here we investigate the fractal dimension as a quantitator of non-Euclidean two-dimensional vascular geometry in a series of paired specimens of primary HCC and surrounding non-tumoral tissue,and discuss why this parameter might provide additional information regarding cancer behavior.The application of fractal geometry to the measurement of liver vascularity and the availability of a computer-aided quantitative method can eliminate errors in visual interpretation,and make it possible to obtain closer-to-reality numerals that are compulsory for any measurement process.
文摘The purpose of this paper is to investigate reasonable cost benefit criteria within the framework of environmental formal safety assessment (FSA). In this study a statistical analysis of oil spill data was carried out based on the report of International Oil Pollution Compensation Funds. According to the statistical study of actual oil spill from tankers, it is found that collisions and groundings are the most probable causes of the oil spills from tankers. Probability distributions of costs of oil spill and oil spill amount are investigated, and a non-linear regression formula between costs of oil spills and oil spill weight are derived. Using the regression formula, an oil spill weight dependent CATStm (Cost of Averting a Ton of oil Spilt) is proposed. Moreover in order to apply the weight dependent CATSthr to cost benefit analysis (CBA), a new cost-effective criterion is newly proposed with considering its concrete application to environmental FSA.
基金Supported by National Oil-gas Project:No XQ-2004-07
文摘As an open standard of data representation,XML breathes new energy to the Web application and the network computing.The development,advantage and status of XML and some standards relating to XML are reviewed.In addition,the authors put forward a method representing logging data and using UML language to establish the conceptual and logical model of logging data;using a logging data,explain how to establish the model as well as how to use XML to display and process geology data.
基金Open Fund of the Key Lab of the Ministry of Education for Image Information Processing and Intelligent Control,China(No.200702)
文摘Co-occurrence matrices have been successfully applied in texture classification and segmentation.However,they have poor computation performance in real-time application.In this paper,the efficient co-occurrence matrix solution for defect detection is focused on,and a method of Fuzzy Label Co-occurrence Matrix (FLCM) set is proposed.In this method,all gray levels are supposed to subject to some fuzzy sets called fuzzy tonal sets and three defective features are defined.Features of FLCM set with various parameters are combined for the final judgment.Unlike many methods,image acquired for learning hasn't to be entirely free of defects.It is shown that the method produces high accuracy and can be a competent candidate for plain colour fabric defect detection.
文摘Objective To evaluate the epicardial fat tissue thickness (EFTT) as a diagnostic criterion for geriatric patients with metabolic syn- drome (MetS). Methods Sixty geriatric patients over 65 years of age were recruited for the study. Patients were divided into two groups: Group 1 (n = 30) consisted of patients with MetS; Group 2 (n = 30) consisted of patients without MetS. Echocardiography was used to measure EFTT in all patients, and blood samples were analyzed for biochemical parameters. Results Compared to Group 2, EFTT levels of Group 1 were statistically higher (P 〈 0.05). In a binary logistic regression analysis, EFTT levels served as the independent factor for meta- bolic syndrome 03 = 17.35, SE = 4.93, Wald = 12.36, P 〈 0.001). Receivers operating characteristic Curve (ROC-curve) analysis revealed that EFTT predicted MetS with 96.7% sensitivity and 86.7% specificity above the level of 7.3 mm [area under the curve = 0.969; 95% con- fidence interval (CI): 0.928-1.00]. Conclusions The present study demonstrated that serum EFTT levels were higher in geriatric patients with MetS and can therefore be used as a diagnostic criterion for MetS.
基金Supported by National Basic Research Program of China,No.2009CB522401grand from Natural Science Foundation ofChina,No. 30870983 and 30971118
文摘AIM:To establish an appropriate primate model of fulminant hepatic failure (FHF).METHODS:We have,for the first time,established a large animal model of FHF in Macaca mulatta by intraperitoneal infusion of amatoxin and endotoxin.Clinical features,biochemical indexes,histopathology and iconography were examined to dynamically investigate the progress and outcome of the animal model.RESULTS:Our results showed that the enzymes and serum bilirubin were markedly increased and the enzyme-bilirubin segregation emerged 36 h after toxin administration.Coagulation activity was significantly decreased.Gradually deteriorated parenchymal abnormality was detected by magnetic resonance imaging (MRI) and ultrasonography at 48 h.The liver biopsy showed marked hepatocyte steatosis and massive parenchymal necrosis at 36 h and 49 h,respectively.The autopsy showed typical yellow atrophy of the liver.Hepatic encephalopathy of the models was also confirmed by hepatic coma,MRI and pathological changes of cerebral edema.The lethal effects of the extrahepatic organ dysfunction were ruled out by their biochemical indices,imaging and histopathology.CONCLUSION:We have established an appropriate large primate model of FHF,which is closely similar to clinic cases,and can be used for investigation of the mechanism of FHF and for evaluation of potential medical therapies.
基金Acknowledgements: This work had the financial support of the Portuguese National Science Foundation (FCT) through the Research Unit, UI 4005, Project Reference PEst-OE/EME/UI4005/2011.
文摘Nowadays, there exist various standards for individual management systems (MSs), at least, one for each stakeholder. New ones will be published. An integrated management system (IMS) aims to integrate some or all components of the business into one coherent and efficient MS. Maximizing integration is more and more a strategic priority in that it constitutes an opportunity to eliminate and/or reduce potential factors of destruction of value for the organizations and also to be more competitive and consequently promote its sustainable success. A preliminary investigation was conducted on a Portuguese industrial company which, over the years, has been adopting gradually, in whole or in part, individualized management system standards (MSSs). A research, through a questionnaire, was performed with the objective to develop, in a real business environment, an adequate and efficient IMS-QES (quality, environment, and safety) model and to potentiate for the future a generic IMS model to integrate other MSSs. The strategy and research methods have taken into consideration the case study. It was obtained a set of relevant conclusions resulting from the statistical analyses of the responses to the survey. Globally, the investigation results, by themselves, justified and prioritized the conception of a model of development of the IMS-QES and consequent definition and validation of a structure of an IMS-QES model, to be implemented at the small- and medium-sized enterprise (SME) where the investigation was conducted.