一、选择题:在A^E选项中选择最佳选项填入对应的题目1.D;2.B;3.A;4.C;5.E;6.E;7.B;8.C;9.D;10.A;11 B;12.A;13.E;14.D;15.C二、填空题1.3 Werdnig-Hoffmann病慢性婴儿型Kugelberg-Welander病2.运动神经元存活基因1(survival motor neuro...一、选择题:在A^E选项中选择最佳选项填入对应的题目1.D;2.B;3.A;4.C;5.E;6.E;7.B;8.C;9.D;10.A;11 B;12.A;13.E;14.D;15.C二、填空题1.3 Werdnig-Hoffmann病慢性婴儿型Kugelberg-Welander病2.运动神经元存活基因1(survival motor neuron 1,SMN1)3.脊髓前角细胞变性肌无力、肌萎缩4.展开更多
To determine whether levels of beta human choriogonadotropin (β - hCG) during the second trimester are a predictor of pre-eclampsia. Methods. A prospective study of 784 women was conducted between their 16th and 20th...To determine whether levels of beta human choriogonadotropin (β - hCG) during the second trimester are a predictor of pre-eclampsia. Methods. A prospective study of 784 women was conducted between their 16th and 20th week of pregnancy. Primigravidas and multigravidas were analyzed separately, and the cutoff point was determined using a receiver operating characteristic curve. The accuracy of β - hCG levels in the prediction of preecla-mpsiawas evaluated. The likelihood ratios were calculated for different levels of β - hCG in both groups. Results. Pre-eclampsia prevalence was 7.1% among primigravidas and 4.6% among multigravidas. The cutoff concentration was 2.0 MoM in both groups. For primigravidas and multigravidas, respectively, the area below the curve was 0.96 and 0.95; sensitivity was 88.5% and 100% ; specificity was 92.0% and 85.6% ; positive predictive value was 0.46 and 0.25; and negative predictive value was 0.99 and 1.0. With a cutoff concentration of 2.0 MoM of β - hCG, the positive likelihood ratio was 11.1 in primigravidas and 6.9 in multigravidas. Conclusion. This study shows that measuring levels of β - hCG during the second trimester of pregnancy is useful in clinical practice to identify pregnant women who will develop pre-eclampsia.展开更多
文摘To determine whether levels of beta human choriogonadotropin (β - hCG) during the second trimester are a predictor of pre-eclampsia. Methods. A prospective study of 784 women was conducted between their 16th and 20th week of pregnancy. Primigravidas and multigravidas were analyzed separately, and the cutoff point was determined using a receiver operating characteristic curve. The accuracy of β - hCG levels in the prediction of preecla-mpsiawas evaluated. The likelihood ratios were calculated for different levels of β - hCG in both groups. Results. Pre-eclampsia prevalence was 7.1% among primigravidas and 4.6% among multigravidas. The cutoff concentration was 2.0 MoM in both groups. For primigravidas and multigravidas, respectively, the area below the curve was 0.96 and 0.95; sensitivity was 88.5% and 100% ; specificity was 92.0% and 85.6% ; positive predictive value was 0.46 and 0.25; and negative predictive value was 0.99 and 1.0. With a cutoff concentration of 2.0 MoM of β - hCG, the positive likelihood ratio was 11.1 in primigravidas and 6.9 in multigravidas. Conclusion. This study shows that measuring levels of β - hCG during the second trimester of pregnancy is useful in clinical practice to identify pregnant women who will develop pre-eclampsia.
