目的观察青光眼睫状体炎综合征反复发作是否会对视网膜神经纤维层厚度及视野产生影响。方法收集2014年7月—2016年7月在我院诊断为青光眼睫状体炎综合征且发作2次的患者16例,将其发病眼作为发作眼组,对侧眼列为对侧眼组,选取在我院健康...目的观察青光眼睫状体炎综合征反复发作是否会对视网膜神经纤维层厚度及视野产生影响。方法收集2014年7月—2016年7月在我院诊断为青光眼睫状体炎综合征且发作2次的患者16例,将其发病眼作为发作眼组,对侧眼列为对侧眼组,选取在我院健康体检者为正常对照组。在第1次及第2次发作眼压控制后3 d内及满3个月时均记录一般资料、眼部常规检查,并运用自动视野计行标准全视野检查,眼科相干光断层扫描仪行以视乳头为中心1.73 m m半径内不同象限视网膜神经纤维层厚度检查。结果各组不同时间点视网膜神经纤维层厚度的比较差异无统计学意义(P>0.05);16例患者在反复发作后出现视野缺损和出现鼻侧阶梯或者旁中心暗点的患者均为0例(0眼)。结论青光眼睫状体炎综合征反复发作对视网膜神经纤维层厚度的改变不明显,但可能出现视野损害。展开更多
Objective:To investigate the value of optic disc retinal nerve fiber layer(RNFL)thickness in the diagnosis of diabetic peripheral neuropathy(DPN).Methods:Ninety patients with type 2 diabetes,including 60 patients with...Objective:To investigate the value of optic disc retinal nerve fiber layer(RNFL)thickness in the diagnosis of diabetic peripheral neuropathy(DPN).Methods:Ninety patients with type 2 diabetes,including 60 patients without DPN(NDPN group)and 30 patients with DPN(DPN group),and 30 healthy participants(normal group)were enrolled.Optical coherence tomography(OCT)was used to measure the four quadrants and the overall average RNFL thickness of the optic disc.The receiver operator characteristic curve was drawn and the area under the curve(AUC)was calculated to evaluate the diagnostic value of RNFL thickness in the optic disc area for DPN.Results:The RNFL thickness of the DPN group was thinner than those of the normal and NDPN groups in the overall average((101.07±12.40)μm vs.(111.07±6.99)μm and(109.25±6.90)μm),superior quadrant((123.00±19.04)μm vs.(138.93±14.16)μm and(134.47±14.34)μm),and inferior quadrant((129.37±17.50)μm vs.(143.60±12.22)μm and(144.48±14.10)μm),and the differences were statistically significant.The diagnostic efficiencies of the overall average,superior quadrant,and inferior quadrant RNFL thicknesses,and a combined index of superior and inferior quadrant RNFL thicknesses were similar,and the AUCs were 0.739(95%confidence interval(CI)0.635–0.826),0.683(95%CI 0.576–0.778),0.755(95%CI 0.652–0.840),and 0.773(95%CI 0.672–0.854),respectively.The diagnostic sensitivity of RNFL thickness in the superior quadrant reached 93.33%.Conclusions:The thickness of the RNFL in the optic disc can be used as a diagnostic method for DPN.展开更多
文摘目的观察青光眼睫状体炎综合征反复发作是否会对视网膜神经纤维层厚度及视野产生影响。方法收集2014年7月—2016年7月在我院诊断为青光眼睫状体炎综合征且发作2次的患者16例,将其发病眼作为发作眼组,对侧眼列为对侧眼组,选取在我院健康体检者为正常对照组。在第1次及第2次发作眼压控制后3 d内及满3个月时均记录一般资料、眼部常规检查,并运用自动视野计行标准全视野检查,眼科相干光断层扫描仪行以视乳头为中心1.73 m m半径内不同象限视网膜神经纤维层厚度检查。结果各组不同时间点视网膜神经纤维层厚度的比较差异无统计学意义(P>0.05);16例患者在反复发作后出现视野缺损和出现鼻侧阶梯或者旁中心暗点的患者均为0例(0眼)。结论青光眼睫状体炎综合征反复发作对视网膜神经纤维层厚度的改变不明显,但可能出现视野损害。
基金the Science and Technology Plan Project of Quanzhou(Nos.2018Z114,2018Z115,and 2019N104S)the Qihang Fund of Fujian Medical University(No.2016QH072)the Health Research Talent Training Project of Fujian(No.2019-ZQN-66),China。
文摘Objective:To investigate the value of optic disc retinal nerve fiber layer(RNFL)thickness in the diagnosis of diabetic peripheral neuropathy(DPN).Methods:Ninety patients with type 2 diabetes,including 60 patients without DPN(NDPN group)and 30 patients with DPN(DPN group),and 30 healthy participants(normal group)were enrolled.Optical coherence tomography(OCT)was used to measure the four quadrants and the overall average RNFL thickness of the optic disc.The receiver operator characteristic curve was drawn and the area under the curve(AUC)was calculated to evaluate the diagnostic value of RNFL thickness in the optic disc area for DPN.Results:The RNFL thickness of the DPN group was thinner than those of the normal and NDPN groups in the overall average((101.07±12.40)μm vs.(111.07±6.99)μm and(109.25±6.90)μm),superior quadrant((123.00±19.04)μm vs.(138.93±14.16)μm and(134.47±14.34)μm),and inferior quadrant((129.37±17.50)μm vs.(143.60±12.22)μm and(144.48±14.10)μm),and the differences were statistically significant.The diagnostic efficiencies of the overall average,superior quadrant,and inferior quadrant RNFL thicknesses,and a combined index of superior and inferior quadrant RNFL thicknesses were similar,and the AUCs were 0.739(95%confidence interval(CI)0.635–0.826),0.683(95%CI 0.576–0.778),0.755(95%CI 0.652–0.840),and 0.773(95%CI 0.672–0.854),respectively.The diagnostic sensitivity of RNFL thickness in the superior quadrant reached 93.33%.Conclusions:The thickness of the RNFL in the optic disc can be used as a diagnostic method for DPN.
