Lymph node metastasis is the most common and basic way in the extending of colorectal tumor. It is an important reason for the difficulty of curing the tumor and the tumor＇s high mortality. And it is also an importan...Lymph node metastasis is the most common and basic way in the extending of colorectal tumor. It is an important reason for the difficulty of curing the tumor and the tumor＇s high mortality. And it is also an important factor that effects surgery treatment. Vascular endothelial growth factor（VEGF） family is a group of factors which specificly act on endothelial cell. VEGF has been shown to be an important regulator of turnour angiogenesis, but its effect on lymphangiogenesis is not so clear. In this review,we discussed VEGF＇s effect on lymphangiogenesis, the colorectal microenvironment＇s effect on the factors expression and the therapeutics via antilymphangiogenesis by inhibiting VEGFR-3 signaling.展开更多
文摘Lymph node metastasis is the most common and basic way in the extending of colorectal tumor. It is an important reason for the difficulty of curing the tumor and the tumor＇s high mortality. And it is also an important factor that effects surgery treatment. Vascular endothelial growth factor（VEGF） family is a group of factors which specificly act on endothelial cell. VEGF has been shown to be an important regulator of turnour angiogenesis, but its effect on lymphangiogenesis is not so clear. In this review,we discussed VEGF＇s effect on lymphangiogenesis, the colorectal microenvironment＇s effect on the factors expression and the therapeutics via antilymphangiogenesis by inhibiting VEGFR-3 signaling.
