结、直肠损伤26例诊治分析

目的探讨结、直肠损伤的诊治经验。方法对26例结、直肠损伤患者的病例资料进行回顾性分析。结果26例均予以手术治疗,行一期单纯修补、"V"型切除或切除吻合术者22例(占87%,22/26),无肠瘘发生。二期肠造瘘或肠外置3例(占12%,3/26),两类手术酌情放或不放腹腔引流。死亡1例,死亡主要原因为失血性休克、严重多发伤。结论结、直肠损伤大部分一期手术是安全的;二期手术仅适用于结、直肠损伤严重、腹腔污染重、全身情况差和腹膜返折以下的直肠损伤。

结直肠损伤的诊治

目的:探讨结、直肠损伤的诊断及治疗。方法:对结、直肠损伤28例的回顾性分析。结果:对结、直肠损伤时间在6 h8 h之内,腹腔污染轻的作一期修补或切除吻合。对损伤时间在8 h以上,腹腔污染严重的行分期手术。结论:提高结、直肠损伤的疗效。

VEGF stimulates lymphangiogenesis in colorectal cancer and the treatment via anti-lymphangiogenesis

Lymph node metastasis is the most common and basic way in the extending of colorectal tumor. It is an important reason for the difficulty of curing the tumor and the tumor＇s high mortality. And it is also an important factor that effects surgery treatment. Vascular endothelial growth factor（VEGF） family is a group of factors which specificly act on endothelial cell. VEGF has been shown to be an important regulator of turnour angiogenesis, but its effect on lymphangiogenesis is not so clear. In this review,we discussed VEGF＇s effect on lymphangiogenesis, the colorectal microenvironment＇s effect on the factors expression and the therapeutics via antilymphangiogenesis by inhibiting VEGFR-3 signaling.