希望“白玉兰奖”越办越好

首届上海戏剧白玉兰奖已经揭晓,它的影响和意义一时难以全面评述。但作为上海是全国第一大城市,又是我国重要的科技、文化和商业中心。长期以来在戏剧盾动中没有一个具有权威和令人向往的文艺大奖,似乎和它所处的地位极不相称,所以一旦出现“白玉兰奖”,必然会引起上海和全国文艺界的注目。我十分赞成白玉兰奖,这不仅是因为我自己是个演员,有资格角逐这项大奖,更主要是它能激发奋剧团创排优秀剧目的积极性,激励演员去创造好每一个创排剧目中的人物,活跃上海的戏剧舞台,催化和助产戏剧文艺事业的繁荣。这次首届白玉兰奖评选结果,我团有三位演员荣幸地当选,我觉得他们是当之无愧的,我自己虽有幸曾被列入候选人,但未能得选。我想不论选中还是落选。

Synthesis and Structure of L-Aspartato- nickel(II) Complex with Benzimidazole

The title complex Ni(C4H5NO4)(C7H6N2)31.75(H2O) (C25H26.5N7NiO5.75, Mr = 575.74) has been prepared and its crystal structure was determined by X-ray diffraction method. The crystal of this chiral complex belongs to monoclinic, space group P21 with a = 13.208(1), b = 10.741(1), c = 19.398(1) ? b = 104.39(1)o, V = 2665.8(4) 3, Z = 4, Dc = 1.435 g/cm3, m(MoKa) = 0.780 mm-1 and F(000) = 1198. The final R = 0.0504 and wR = 0.1267 for 9159 observed reflections (I > 2s(I)), and R = 0.065 and wR = 0.1299 for 11006 independent reflections. The complex assumes a distorted octa- hedral coordinate geometry formed by one aspartate dianion and three benzimidazole ligands. The aspartate chelates to the Ni atom as a tridentate ligand. The lattice water molecules are hydrogen- bonded to the Ni complex molecule.

Autophagy Enhances the Aggressiveness of Human Colorectal Cancer Cells and Their Ability to Adapt to Apoptotic Stimulus

Objective To investigate LC3B-Ⅱand active caspase-3 expression in human colorectal cancer to elucidate the role of autophagy and to explore the relationship of autophagy with apoptosis in human colorectal cancer. Methods LC3B expression was detected by immunohistochemistry in 53 human colorectal cancer tissues and 20 normal colon tissues.The protein levels of LC3B-Ⅱand active caspase-3 were also determined by Western blot analysis in 23 human colorectal cancer tissues and 10 normal colon tissues. Results LC3B was expressed both in cancer cells and normal epithelial cells.LC3B expression in the peripheral area of cancer tissues was correlated with several clinicopathological factors,including tumor differentiation(P=0.002),growth pattern of the tumor margin (P=0.028),pN(P=0.002),pStage(P=0.032),as well as vessel and nerve plexus invasion(P=0.002).The protein level of LC3B-Ⅱin cancer tissue was significantly higher than in normal tissue(P=0.038),but the expression of active forms of procaspase-3 in cancer tissue was lower(P=0.041).There was a statistically significant positive correlation between the expression levels of LC3B-Ⅱand the active forms of procaspase-3(r=0.537,P=0.008). Conclusions Autophagy has a prosurvival role in human colorectal cancer.Autophagy enhances the aggressiveness of colorectal cancer cells and their ability to adapt to apoptotic stimulus.

Eight-Regularity of Types of Crop Capacity Structure of Winter Wheat

The elements of crop capacity structure of 13 summer characteristics in 33 winter wheat varieties, qualitative three-regularity and quantitative eight-regularity are investigated through the application of systematic approach. The principle of triadness applied in a language, in a genetic code and other codes is used, i.e. the logic homology is employed. The purpose are （1） to show the use of a systematic approach to the analysis of elements of crop capacity structure of winter wheat; （2） to analyze efficiency, the years of harvests and winter hardiness; （3） to find the way of selection and varieties assessment in terms of the elements efficiency. The quantitative compatibility as the highest with the sign ＂＋＂ and the lowest with the sign ＂-＂ in terms of elements efficiency gives eight types of crop capacities. The type of crop capacity structure ＂＋＋＋＂ can serve as a full （higher） measure of a variety adaptableness and optimality of technologies. The triad of three characteristics as a type-＂＋＋＋＂ in which the first sign is the quantity of ears （QE）; the second is a quantity of grains （QG）; the third is the weight of grains （WG） creates the highest level of crop capacity.

明年的改革和发展将继续加快

吾兄: 1993年即将过去。当此岁尾,此间可以强烈感受到的,是为加快明年的改革开放和现代化建设的步伐而厉兵秣马,志在必胜的攻坚战气氛。可以预见,1994年中国的改革和发展将继续加快。 进入12月份的第一天,全国经济工作会议就在北京开幕。参加会议的是各省、自治区、直辖市,计划单列市,以及国务院各部委负责人。这是一次全面部署1994年经济工作的重要会议。会前。

国学赏析

【选自】《论语·里仁》【原文】子日：＂不患无位,患所以立;不患莫己知,求为可知也。＂【译文】孔子说：＂不怕没有官位,就怕自己没有学到赖以站得住脚的东西。不怕没有人知道自己,只求自己成为有真才实学值得为人们知道的人。＂【评析】这是孔子对自己和自己的学生经常谈论的问题,是他立身处世的基本态度。孔子并非不想成名成家,并非不想身居要职,而是希望他的学生必须首先立足于自身的学问、修养、才能的培养,具备足以胜任官职的各方面素质。这种思路是可取的。

Dynamics of a stage-structured single population system with winter hibernation and impulsive effect in polluted environment

In this work, we construct a stage-structured single population system with winter hiber- nation and impulsive effect in polluted environment. All solutions of the investigated system are proved to be uniformly ultimately bounded. The conditions of the population- extinction solution of the investigated system are obtained. The permanent condition of the investigated system is also obtained. Finally, numerical analysis is inserted to illustrate the results. Our results indicate that the environmental pollution will reduce biological diversity of the natural world. Our results also provide reliable tactic basis for the practical biological resource management.

Antigenic variation of the human influenza A(H3N2) virus during the 2014–2015 winter season

The human influenza A （H3N2） virus dominated the 2014-2015 winter season in many countries and caused massive morbid- ity and mortality because of its antigenic variation. So far, very little is known about the antigenic patterns of the recent H3N2 virus. By systematically mapping the antigenic relationships of H3N2 strains isolated since 2010, we discovered that two groups with obvious antigenic divergence, named SW13 （A/Switzerland/9715293/2013-1ike strains） and HK14 （A/Hong Kong/5738/2014-1ike strains）, co-circulated during the 2014-2015 winter season. HK14 group co-circulated with SW13 in Europe and the United States during this season, while there were few strains of HK14 in China's Mainland, where SW13 has dominated since 2012. Furthermore, we found that substitutions near the receptor-binding site on hemagglutinin played an im- portant role in the antigenic variation of both the groups. These findings provide a comprehensive understanding of the recent antigenic evolution of H3N2 virus and will aid in the selection of vaccine strains.

Aprisco Field Station: the spatial structure of a new experimental site focused on agroecology

The Dehesa ecosystem provides important social and economic values across the Iberian Peninsula.Assessing the temporal dynamics of this system under climate change is important for the maintenance and conservation of these highly valuable ecosystems.Here,we present the baseline data of an observational plot network in the Dehesa that will form the foundation for monitoring long-term dynamics and for experimental manipulations testing the mechanisms driving resilience within the Dehesa.The initial surveys indicate that the forest structure is typical for the Dehesa,which suggests it is an exemplary site for examining temporal dynamics of this ecosystem.We present these initial data to encourage collaborations from international scientists via either direct experimental projects or meta-analyses.

Computational analysis of deleterious missense mutations in aspartoacylase that cause Canavan's disease

In this work, the most detrimental missense mutations of aspartoacylase that cause Canavan's disease were identified computationally and the substrate binding efficiencies of those missense mutations were analyzed. Out of 30 missense mutations, I-Mutant 2.0, SIFT and PolyPhen programs identified 22 variants that were less stable, deleterious and damaging respectively. Subsequently, modeling of these 22 variants was performed to understand the change in their conformations with respect to the native aspartoacylase by computing their root mean squared deviation (RMSD). Furthermore, the native protein and the 22 mutants were docked with the substrate NAA (N-Acetyl-Aspartic acid) to explain the substrate binding efficiencies of those detrimental missense mutations. Among the 22 mutants, the docking studies identified that 15 mutants caused lower binding affinity for NAA than the native protein. Finally, normal mode analysis determined that the loss of binding affinity of these 15 mutants was caused by altered flexibility in the amino acids that bind to NAA compared with the native protein. Thus, the pre- sent study showed that the majority of the substrate-binding amino acids in those 15 mutants displayed loss of flexibility, which could be the theoretical explanation of decreased binding affinity between the mutant aspartoacylases and NAA.

Research progress of the role and mechanism of extracellular signal-regulated protein kinase 5(ERK5) pathway in pathological pain

Extracellular signal-regulated protein kinase 5 （ERK5）, also known as big mitogen-activated protein kinase 1 （MAPK1）, is an important member of ERK family, which is a subfamily of the large MAPK family. ERK5 is expressed in many tissues, including the dorsal root ganglion （DRG） neurons and the spinal cord. In this review, we focus on elaborating ERK5-associated pathway in pathological pain, in which the ERK5/CREB （cyclic adenosine monophos- phate （cAMP）-response element-binding protein） pathway plays a crucial role in the transduction of pain signal and contributes to pain hypersensitivity. ERK5 activation in the spinal dorsal horn occurs mainly in microglia. The activation of ERK5 can be mediated by N-methyI-D-aspartate （NMDA） receptors. We also elaborate the relationship between ERK5 activation and nerve growth factor-tyrosine kinase A （NGF-TrkA）, and the connection between ERK5 activation and brain-derived neurotrophic factor （BDNF） in pathological pain in detail.