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受体功能区结构与环境内分泌干扰效应生物差异的关系 被引量:2
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作者 高常安 张爱茜 +2 位作者 蔺远 韩朔睽 王连生 《生态毒理学报》 CAS CSCD 2007年第4期363-374,共12页
环境中存在的多种内分泌干扰物能够与生物体内的天然激素受体选择性结合并产生多种生物效应,由于受体功能区三维结构的不同,其内分泌干扰活性存在着种间、种内、组织间等的种种差异,限制了不同物种间毒性效应的外推研究,增加了环境内分... 环境中存在的多种内分泌干扰物能够与生物体内的天然激素受体选择性结合并产生多种生物效应,由于受体功能区三维结构的不同,其内分泌干扰活性存在着种间、种内、组织间等的种种差异,限制了不同物种间毒性效应的外推研究,增加了环境内分泌干扰物筛选和风险评价的难度.论文综述了基于受体介导的环境内分泌干扰物生物活性与相应受体选择性及受体功能区结构关系的研究进展,并利用分子模拟方法分析探讨了雌激素受体与部分化合物结合作用模式,讨论了目前存在的问题,对以后有关方面的研究提出了建议. 展开更多
关键词 内分泌干扰物 受体 功能结构 亲合力 结合自由能
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玻璃体切割联合内界膜剥离术对高度近视MHRD患者黄斑区结构功能的影响及术后黄斑裂孔闭合影响因素分析 被引量:3
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作者 史伟 姜娜 《中国医药导报》 CAS 2020年第27期116-119,共4页
目的探讨玻璃体切割联合内界膜剥离术(ILMP)对高度近视黄斑裂孔性视网膜脱离(MHRD)患者黄斑区结构功能的影响及术后黄斑裂孔闭合的影响因素。方法回顾性分析2016年2月—2018年8月于河北省邯郸市眼科医院行玻璃体切割联合ILMP治疗的69例... 目的探讨玻璃体切割联合内界膜剥离术(ILMP)对高度近视黄斑裂孔性视网膜脱离(MHRD)患者黄斑区结构功能的影响及术后黄斑裂孔闭合的影响因素。方法回顾性分析2016年2月—2018年8月于河北省邯郸市眼科医院行玻璃体切割联合ILMP治疗的69例高度近视MHRD患者的临床资料,根据术后3个月黄斑裂孔闭合随访结果,分为闭合组(57例)及未闭合组(12例)。所有患者均于手术前后行光学相干断层扫描、裂隙灯显微镜、最佳矫正视力检查,测量术后黄斑中心凹视网膜厚度(FRT)、黄斑中心凹下脉络膜厚度(SFCT)变化情况及术前黄斑裂孔参数、指数,并结合患者的临床资料用单因素及多因素logistic回归模型分析术后黄斑裂孔闭合影响因素。结果两组术前FRT、SFCT比较,差异无统计学意义(P>0.05)。术后,两组FRT、SFCT均薄于术前,且闭合组薄于未闭合组,差异有统计学意义(P<0.05)。两组裂孔最小径(MD)、黄斑裂孔指数(MHI)和裂孔牵拉指数(THI)比较,差异有统计学意义(P<0.05)。多因素logistic回归分析显示,MD(OR=1.003,95%CI:1.000~1.005,P=0.048)、MHI(OR=108.369,95%CI:5.047~2326.771,P=0.003)、THI(OR=215.263,95%CI:2.248~20609.444,P=0.021)均为患者术后黄斑裂孔闭合的独立危险因素。结论玻璃体切割联合ILMP可明显改善高度近视MHRD患者的黄斑区结构功能,MD、MHI、THI均为影响患者术后黄斑裂孔闭合的危险因素。 展开更多
关键词 玻璃体切割 内界膜剥离术 高度近视黄斑裂孔性视网膜脱离 黄斑结构功能 黄斑裂孔闭合
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侯选抑瘤基因BRD7及家族蛋白的功能研究进展 被引量:5
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作者 刘华英 李桂源 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2005年第9期811-816,共6页
溴区结构(bromodomain)是近年来发现的广泛分布于多种生物中的一种高度保守的结构域,溴区结构蛋白通过参与信号依赖性的基因转录调控而广泛参与细胞内重要的生命活动.BRD7基因是1999年克隆的一个新的bromodomain基因,GenBank登录号为AF1... 溴区结构(bromodomain)是近年来发现的广泛分布于多种生物中的一种高度保守的结构域,溴区结构蛋白通过参与信号依赖性的基因转录调控而广泛参与细胞内重要的生命活动.BRD7基因是1999年克隆的一个新的bromodomain基因,GenBank登录号为AF152604或AF152605.eMotif分析表明,BRD7蛋白包含多个磷酸化位点和一个保守bromodomain功能域,Blast显示BRD7蛋白与人的Celtix-1及鼠的bromodomain蛋白BP75具有高度的同源性.利用转基因技术已证实,在鼻咽癌细胞系HNE1中过表达BRD7基因可以抑制其细胞生长和细胞周期G1-S的进程,并部分逆转鼻咽癌细胞HNE1的恶性表型.为了全面地揭示BRD7基因的细胞内生物学功能,深入了解BRD7基因的细胞内整体信息流向,中南大学肿瘤研究所细胞遗传室已从上、中、下游三个不同层面对BRD7基因的功能研究展开了初步的探索. 展开更多
关键词 BRD7基因 结构功能 BRD7基凼功能
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术前糖化血红蛋白水平与2型糖尿病患者超声乳化术后黄斑区结构功能改变的关系分析 被引量:2
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作者 甄宏 高云 高文捷 《中国医师进修杂志》 2022年第7期593-597,共5页
目的探讨术前糖化血红蛋白(HbA_(1c))水平与2型糖尿病(T2DM)患者超声乳化术后黄斑区结构功能改变的关系。方法选取2018年1月至2021年6月合肥市第一人民医院118例行超声乳化术的T2DM白内障患者,均为单眼白内障,根据术前HbA_(1c)水平,将T... 目的探讨术前糖化血红蛋白(HbA_(1c))水平与2型糖尿病(T2DM)患者超声乳化术后黄斑区结构功能改变的关系。方法选取2018年1月至2021年6月合肥市第一人民医院118例行超声乳化术的T2DM白内障患者,均为单眼白内障,根据术前HbA_(1c)水平,将T2DM患者分为高HbA_(1c)组55例(HbA1c>7.0%)和正常HbA_(1c)组63例(HbA1c≤7.0%),比较两组患者黄斑中心凹视网膜厚度(CST)、黄斑总容积(CV)、黄斑中心凹脉络膜厚度(SFCT)及术后黄斑水肿(PCME)发生率,分析患者发生PCME的危险因素。结果超声乳化术后1周、1个月、3个月,高HbA1c组CST水平均显著高于正常HbA_(1c)组[(256.21±19.27)μm比(242.33±14.63)μm、(277.41±16.39)μm比(248.12±11.54)μm、(242.51±11.52)μm比(234.87±9.34)μm],差异有统计学意义(P<0.05);超声乳化术后3个月,高HbA1c组CV水平均显著高于正常HbA1c组[(10.40±0.51)mm^(2)比(10.17±0.47)mm^(2)],差异有统计学意义(P<0.05)。高HbA_(1c)组PCME发生率显著高于正常HbA_(1c)组[25.45%(14/55)比7.94%(5/63)],差异有统计学意义(P<0.05)。术前HbA_(1c)>7.0%、术前存在视网膜病变是导致患者发生PCME的独立危险因素(P<0.05)。结论T2DM白内障患者术前HbA_(1c)水平会影响超声乳化术后黄斑区视网膜及脉络膜结构,且术前HbA_(1c)>7.0%的患者PCME风险增加。 展开更多
关键词 糖尿病 2型 黄斑水肿 糖化血红蛋白 超声乳化术 黄斑结构功能 影响因素
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p型Cu/Q(Q=S,Se,Te)透明导体的设计、制备及性能研究
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作者 吴历斌 黄富强 江莞 《无机材料学报》 SCIE EI CAS CSCD 北大核心 2009年第3期427-432,共6页
利用结构功能区思想的导电功能区和透光功能区,提出了层状p型Cu/Q透明导体的设计模型.LaCuOTe和Sr3Cu2Sc2O5S2因结构层[Cu2Te2]和[Cu2S2]对应导电功能区、[La2O2]和[Sr3Sc2O5]对应透光功能区,符合模型设计思想,是兼具高导电性和高透光... 利用结构功能区思想的导电功能区和透光功能区,提出了层状p型Cu/Q透明导体的设计模型.LaCuOTe和Sr3Cu2Sc2O5S2因结构层[Cu2Te2]和[Cu2S2]对应导电功能区、[La2O2]和[Sr3Sc2O5]对应透光功能区,符合模型设计思想,是兼具高导电性和高透光性的透明导体,光谱和电导等验证了模型设计p型透明导体的可行性和正确性.从功能区角度,改变LaCuOS中导电功能层([Cu2S2]→[Cu2Te2])可显著提高材料导电性(10-3S/cm→100S/cm);替换LaCuOTe中透光功能层([La2O2]→[Sr3Sc2O5])能可控改善材料透光性(2.3eV→3.1eV). 展开更多
关键词 p型Cu/Q 透明导体 导电率 层状结构 结构功能区
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Eco-economic Background of Hilly-Gullied Loess Region and Optimized Eco-productive Paradigm of Small Watersheds 被引量:3
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作者 孔正红 张新时 朱桂杰 《Acta Botanica Sinica》 CSCD 2003年第10期1174-1185,共12页
A thorough analysis on its natural environment as well as social economic status of the hilly-gullied loess region is presented. A small watershed, the dominant landscape unit of the region, has been singled out for f... A thorough analysis on its natural environment as well as social economic status of the hilly-gullied loess region is presented. A small watershed, the dominant landscape unit of the region, has been singled out for further and specific study on landscape pattern and function, its social and economic distinctions. The authors proposed several principles based on its eco-economic background study, which includes water balance and efficient use principle, co-development of grass and agro-forestry principle, location optimization principle. Integrated with detailed analysis of a small watershed, an eco-productive paradigm for the loess land's development based on a small watershed scale was worked out. It consists of circle pattern with villages at core for high efficient agriculture production, hierarchical pattern along the slope for eco-economic development, point-axis pattern for commodity production and circulation in small watersheds and core-margin pattern for exchanges among watersheds. 展开更多
关键词 hilly-gullied loess region small watershed landscape pattern and function location optimization
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Major Function Oriented Zone: New Method of Spatial Regulation for Reshaping Regional Development Pattern in China 被引量:31
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作者 FAN Jie SUN Wei +1 位作者 ZHOU Kan CHEN Dong 《Chinese Geographical Science》 SCIE CSCD 2012年第2期196-209,共14页
Newest planning methods implemented by Chinese government are promoting a coordinated regional development and shaping an orderly spatial structure by applying the regulation of territorial function. This article anal... Newest planning methods implemented by Chinese government are promoting a coordinated regional development and shaping an orderly spatial structure by applying the regulation of territorial function. This article analyzes the problems of spatial planning and regional strategy caused by the wrongly-set primary goal of economic development; it states that the three-fold objective of competitiveness, sustainability, and welfare fairness shall be the principal for China to implement the spatial regulation in the new era; it discusses about theoretical thoughts and technology framework of conducting the ′Major Function Oriented Zone′ based on their different major functions that each region plays in urbanization and industrialization, ecological constructions, grain productions, and protection of natural and cultural heritages; it introduces the new concept of ′Major Function Oriented Zone′ that include the major functions category, the stereo regional equilibrium mode, the two-level zoning specification, and the territorial development intensity; it offers a zoning scheme that defines development-optimized and development-prioritized zones as regions with massive urbanization and industrialization, development-restricted zones as ecological constructing or grain producing regions, development-prohibited zones as natural and cultural heritage protecting regions; and finally it addresses the main obstacle for implementing ′Major Function Oriented Zone′, which is the institutional arrangement of the supreme goal of high GDP growth rate that is currently being implemented. 展开更多
关键词 Major Function Oriented Zone (MFOZ) spatial regulation regional development China
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Interface microstructure and mechanical properties of selective laser melted multilayer functionally graded materials 被引量:6
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作者 WANG Di DENG Guo-wei +4 位作者 YANG Yong-qiang CHEN Jie WU Wei-hui WANG Hao-liang TAN Chao-lin 《Journal of Central South University》 SCIE EI CAS CSCD 2021年第4期1155-1169,共15页
Functionally graded material(FGM)can tailor properties of components such as wear resistance,corrosion resistance,and functionality to enhance the overall performance.The selective laser melting(SLM)additive manufactu... Functionally graded material(FGM)can tailor properties of components such as wear resistance,corrosion resistance,and functionality to enhance the overall performance.The selective laser melting(SLM)additive manufacturing highlights the capability in manufacturing FGMs with a high geometrical complexity and manufacture flexibility.In this work,the 316L/CuSn10/18Ni300/CoCr four-type materials FGMs were fabricated using SLM.The microstructure and properties of the FGMs were investigated to reveal the effects of SLM processing parameters on the defects.A large number of microcracks were found at the 316L/CuSn10 interface,which initiated from the fusion boundary of 316L region and extended along the building direction.The elastic modulus and nano-hardness in the 18Ni300/CoCr fusion zone decreased significantly,less than those in the 18Ni300 region or the CoCr region.The iron and copper elements were well diffused in the 316L/CuSn10 fusion zone,while elements in the CuSn10/18Ni300 and the 18Ni300/CoCr fusion zones showed significantly gradient transitions.Compared with other regions,the width of the CuSn10/18Ni300 interface and the CuSn10 region expand significantly.The mechanisms of materials fusion and crack generation at the 316L/CuSn10 interface were discussed.In addition,FGM structures without macro-crack were built by only altering the deposition subsequence of 316L and CuSn10,which provides a guide for the additive manufacturing of FGM structures. 展开更多
关键词 selective laser melting multilayer functionally graded material interfacial characterization crack defects mechanical properties
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Green Development
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《China Today》 2017年第2期39-39,共1页
A main development concept, green development highlights the importance of harmony between man and nature. The 13th Five-Year Plan period (2016-2020), accentuates the eco-friendly approach to development in efforts to... A main development concept, green development highlights the importance of harmony between man and nature. The 13th Five-Year Plan period (2016-2020), accentuates the eco-friendly approach to development in efforts to promote the harmonious existence of man and nature. Construction of functional regions in which to promote low-carbon and circular development, conservation, efficient resource utilization, and environmental protection that safeguards China's ecological security will be accelerated. Building an economic structure conducive to green, low-carbon and circular development, and maintaining an eco-conservation perspective on every facet of economic, political, cultural, and social development are now imperative. Our goal is to ensure that the land we inherit remains blessed with green mountains, clear waters, and fresh air. 展开更多
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Urban Integrated Activity Zone (UIAZ) in Shanghai
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作者 Shunyao Zhang Yi Chen 《Sociology Study》 2014年第11期965-973,共9页
Urban integrated activity zone (UIAZ) refers to multi-functional area that can provide various services. Integrated activity zone (IAZ), which is based on the existing financial district and Central Business Distr... Urban integrated activity zone (UIAZ) refers to multi-functional area that can provide various services. Integrated activity zone (IAZ), which is based on the existing financial district and Central Business District (CBD), often weakens administrative boundaries and changes the original single functional partition. It emphasizes the mixture of different functions and the vitality of the central area. The construction of IAZ is different from the simple space construction of economy and material production. IAZ emphasizes the participation of city dwellers in urban renewal process. Shanghai IAZs are those vigorous public activity centers in Shanghai. ]ust like those active cells, IAZs in Shanghai are to inspire and improve the comprehensive competitiveness and vitality of the city at macro, intermediate, and micro level, they are the public places in which urban cultural life takes place, develops, and precipitates. This paper provides broad and profound presentation on IAZ structure planning in Shanghai: mix-used function, multi-dimensions scale, people oriented development (POD) transportation, commercial development, and city form vitality. This paper provides not only qualitative analysis, but also makes a serious attempt to quantify the result and statement. 展开更多
关键词 Integrated activity zone (IAZ) mix-used function city vitality
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An EcoCity model for regulating urban land cover structure and thermal environment: Taking Beijing as an example 被引量:21
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作者 KUANG WenHui YANG TianRong +3 位作者 LIU AiLin ZHANG Chi LU DengSheng CHI WenFeng 《Science China Earth Sciences》 SCIE EI CAS CSCD 2017年第6期1098-1109,共12页
Urban land-use/cover changes and their effects on the eco-environment have long been an active research topic in the urbanization field. However, the characteristics of urban inner spatial heterogeneity and its quanti... Urban land-use/cover changes and their effects on the eco-environment have long been an active research topic in the urbanization field. However, the characteristics of urban inner spatial heterogeneity and its quantitative relationship with thermal environment are still poorly understood, resulting in ineffective application in urban ecological planning and management.Through the integration of "spatial structure theory" in urban geography and "surface energy balance" in urban climatology, we proposed a new concept of urban surface structure and thermal environment regulation to reveal the mechanism between urban spatial structure and surface thermal environment. We developed the EcoCity model for regulating urban land cover structure and thermal environment, and established the eco-regulation thresholds of urban surface thermal environments. Based on the comprehensive analysis of experimental observation, remotely sensed and meteorological data, we examined the spatial patterns of urban habitation, industrial, infrastructure service, and ecological spaces. We examined the impacts of internal land-cover components(e.g., urban impervious surfaces, greenness, and water) on surface radiation and heat flux. This research indicated that difference of thermal environments among urban functional areas is closely related to the proportions of the land-cover components.The highly dense impervious surface areas in commercial and residential zones significantly increased land surface temperature through increasing sensible heat flux, while greenness and water decrease land surface temperature through increasing latent heat flux. We also found that different functional zones due to various proportions of green spaces have various heat dissipation roles and ecological thresholds. Urban greening projects in highly dense impervious surfaces areas such as commercial, transportation, and residential zones are especially effective in promoting latent heat dissipation efficiency of vegetation, leading to strongly cooling effect of unit vegetation coverage. This research indicates that the EcoCity model provides the fundamentals to understand the coupled mechanism between urban land use structure and surface flux and the analysis of their spatiotemporal characteristics. This model provides a general computational model system for defining urban heat island mitigation, the greening ratio indexes, and their regulating thresholds for different functional zones. 展开更多
关键词 Urban land-use/cover Urban impervious surface Ecological regulation Thermal environment Remote sensing
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