This paper presents a novel approach to feature subset selection using genetic algorithms. This approach has the ability to accommodate multiple criteria such as the accuracy and cost of classification into the proces...This paper presents a novel approach to feature subset selection using genetic algorithms. This approach has the ability to accommodate multiple criteria such as the accuracy and cost of classification into the process of feature selection and finds the effective feature subset for texture classification. On the basis of the effective feature subset selected, a method is described to extract the objects which are higher than their surroundings, such as trees or forest, in the color aerial images. The methodology presented in this paper is illustrated by its application to the problem of trees extraction from aerial images.展开更多
A new butyrolactone derivative,namely butyrolactone Ⅷ （1）,and six known butyrolactones （2-7） were separated from the ethyl acetate （EtOAc） extract of the fermentation broth of a fungus,Aspergillus terreus MXH-2...A new butyrolactone derivative,namely butyrolactone Ⅷ （1）,and six known butyrolactones （2-7） were separated from the ethyl acetate （EtOAc） extract of the fermentation broth of a fungus,Aspergillus terreus MXH-23.The chemical structures of these metabolites were identified by analyzing their nuclear magnetic resonance （NMR） and mass spectrometry （MS）.Known butyrolactone derivatives contain an α,β-unsaturated γ-lactone ring with α-hydroxyl and y-benzyl,and butyrolactone Ⅷ （1） was the first butyrolactones contains α-benzyl and γ-hydroxyl on α,β-unsaturated lactone ring.All of the butyrolactone derivatives were tested for their anti-influenza （H 1N 1） effects.Derivatives 4 and 7 showed moderate antiviral activities while the newly-identified,derivative 1,did not.展开更多
Image enhancement is a popular technique,which is widely used to improve the visual quality of images.While image enhancement has been extensively investigated,the relevant quality assessment of enhanced images remain...Image enhancement is a popular technique,which is widely used to improve the visual quality of images.While image enhancement has been extensively investigated,the relevant quality assessment of enhanced images remains an open problem,which may hinder further development of enhancement techniques.In this paper,a no-reference quality metric for digitally enhanced images is proposed.Three kinds of features are extracted for characterizing the quality of enhanced images,including non-structural information,sharpness and naturalness.Specifically,a total of 42 perceptual features are extracted and used to train a support vector regression(SVR) model.Finally,the trained SVR model is used for predicting the quality of enhanced images.The performance of the proposed method is evaluated on several enhancement-related databases,including a new enhanced image database built by the authors.The experimental results demonstrate the efficiency and advantage of the proposed metric.展开更多
The present study was designed to establish a suitable assay to explore CCR2 b receptor antagonists from the natural products of Artemisia rupetris and Leontopodium leontopodioides. An aequorin assay was developed as ...The present study was designed to establish a suitable assay to explore CCR2 b receptor antagonists from the natural products of Artemisia rupetris and Leontopodium leontopodioides. An aequorin assay was developed as a cell-based assay suitable for 384-well microplate and used for screening CCR2 b receptor antagonists from natural products. Through establishing suitable conditions, the assay was shown to be suitable for screening of CCR2 b receptor antagonists. Seven compounds were identified in preliminary screening. Five of them showed evident dose-response relationship in secondary screening. The structure–activity relationship study suggested that 7-position hydroxyl group of flavonoids was necessary, a polar group should be introduced on the 3-position, and the substituents on 2-position benzene ring of flavonoids have little influence on the potentency of the inhibition activity on CCR2 b receptor. The ortho-position dihydroxyl structure in quinic acid compounds may be important. In conclusion, Compounds HR-1, 5, 7, and AR-20, 35 showed activity as antagonist of CCR2 b receptor, which shed lights on the development of novel drugs as CCR2 b receptor antagonists for preventing inflammation related diseases.展开更多
文摘This paper presents a novel approach to feature subset selection using genetic algorithms. This approach has the ability to accommodate multiple criteria such as the accuracy and cost of classification into the process of feature selection and finds the effective feature subset for texture classification. On the basis of the effective feature subset selected, a method is described to extract the objects which are higher than their surroundings, such as trees or forest, in the color aerial images. The methodology presented in this paper is illustrated by its application to the problem of trees extraction from aerial images.
基金supported by National Natural Science Foundation of China (Nos.41176120 and 30973627)the National High Technology Research and Development Program of China (No.2013AA092901)+3 种基金the Program for New Century Excellent Talents in University (No.NCET12-0499)Promotive Research Fund for Excellent Young and Middle-Aged Scientists of Shandong Province (BS 2010HZ027)the Public Projects of State Oceanic Administration (No. 2010418022-3)the Program for Changjiang Scholars and Innovative Research Team in University (No.IRT0944)
文摘A new butyrolactone derivative,namely butyrolactone Ⅷ （1）,and six known butyrolactones （2-7） were separated from the ethyl acetate （EtOAc） extract of the fermentation broth of a fungus,Aspergillus terreus MXH-23.The chemical structures of these metabolites were identified by analyzing their nuclear magnetic resonance （NMR） and mass spectrometry （MS）.Known butyrolactone derivatives contain an α,β-unsaturated γ-lactone ring with α-hydroxyl and y-benzyl,and butyrolactone Ⅷ （1） was the first butyrolactones contains α-benzyl and γ-hydroxyl on α,β-unsaturated lactone ring.All of the butyrolactone derivatives were tested for their anti-influenza （H 1N 1） effects.Derivatives 4 and 7 showed moderate antiviral activities while the newly-identified,derivative 1,did not.
基金supported in part by the National Natural Science Foundation of China under Grant 61379143in part by the Fundamental Research Funds for the Central Universities under Grant 2015QNA66in part by the Qing Lan Project of Jiangsu Province
文摘Image enhancement is a popular technique,which is widely used to improve the visual quality of images.While image enhancement has been extensively investigated,the relevant quality assessment of enhanced images remains an open problem,which may hinder further development of enhancement techniques.In this paper,a no-reference quality metric for digitally enhanced images is proposed.Three kinds of features are extracted for characterizing the quality of enhanced images,including non-structural information,sharpness and naturalness.Specifically,a total of 42 perceptual features are extracted and used to train a support vector regression(SVR) model.Finally,the trained SVR model is used for predicting the quality of enhanced images.The performance of the proposed method is evaluated on several enhancement-related databases,including a new enhanced image database built by the authors.The experimental results demonstrate the efficiency and advantage of the proposed metric.
基金supported by the Major Scientific and Technological Special Project for Significant New Drugs Creation(No.2012ZX09504001-001)National Natural Science Foundation of China(No.81102876+2 种基金81430082)the Fundamental Research Funds for the Central Universities(No.2015ZD005)333 high level project of Jiangsu Province(NO.BRA2014245)
文摘The present study was designed to establish a suitable assay to explore CCR2 b receptor antagonists from the natural products of Artemisia rupetris and Leontopodium leontopodioides. An aequorin assay was developed as a cell-based assay suitable for 384-well microplate and used for screening CCR2 b receptor antagonists from natural products. Through establishing suitable conditions, the assay was shown to be suitable for screening of CCR2 b receptor antagonists. Seven compounds were identified in preliminary screening. Five of them showed evident dose-response relationship in secondary screening. The structure–activity relationship study suggested that 7-position hydroxyl group of flavonoids was necessary, a polar group should be introduced on the 3-position, and the substituents on 2-position benzene ring of flavonoids have little influence on the potentency of the inhibition activity on CCR2 b receptor. The ortho-position dihydroxyl structure in quinic acid compounds may be important. In conclusion, Compounds HR-1, 5, 7, and AR-20, 35 showed activity as antagonist of CCR2 b receptor, which shed lights on the development of novel drugs as CCR2 b receptor antagonists for preventing inflammation related diseases.
