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Structure-Property Relationships and Models of Controlled Drug Delivery of Biodegradable Poly (D, L-lactic acid) Microspheres 被引量:8
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作者 潘吉铮 章莉娟 钱宇 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2004年第6期869-876,共8页
An oil-in-water (O/W) solvent evaporation method was used to prepare biodegradable microspheresbased on poly(D,L-lactic acid) (PLA). Nifedipine, a hydrophobic drug, was chosen as a model molecule in the studyof drug e... An oil-in-water (O/W) solvent evaporation method was used to prepare biodegradable microspheresbased on poly(D,L-lactic acid) (PLA). Nifedipine, a hydrophobic drug, was chosen as a model molecule in the studyof drug entrapment and release. Effect of preparation conditions on the size, morphology, drug loading, and releaseprofiles of micropheres was investigated. Based on in vitro release experimental findings, a diffusion/dissolutionmodel was presented for quantitative description of the resulting release behaviors and drug release kinetics fromPLA microspheres analyzed. The mathematical models were used to predict the effect of microstructure on theresulting drug release. It provided an approach to determine the suitable structure parameters for microspheres toachieve desired drug release behaviors. 展开更多
关键词 MICROSPHERES drug delivery NIFEDIPINE controlled release solventevaporation structure-property relationships MODEL
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五配位铝强化硅铝固体酸的固体核磁共振研究
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作者 王子春 黄骏 姜怡娇 《波谱学杂志》 CAS 北大核心 2021年第4期552-570,共19页
Brønsted酸(B酸)是无定型硅铝(ASAs)表面最重要的催化活性位点.通常认为B酸位的形成只依赖于不饱和四配位铝(AlIV),且仅具有弱B酸性.通过合成五配位铝(AlV)富集的ASAs能够大幅提升高铝硅比(Al/Si)时的B酸含量及强度,克服传统AlIV... Brønsted酸(B酸)是无定型硅铝(ASAs)表面最重要的催化活性位点.通常认为B酸位的形成只依赖于不饱和四配位铝(AlIV),且仅具有弱B酸性.通过合成五配位铝(AlV)富集的ASAs能够大幅提升高铝硅比(Al/Si)时的B酸含量及强度,克服传统AlIV富集的ASAs的酸性强化瓶颈.本文介绍了AlV在ASAs酸性强化及合成单原子催化剂中的重要作用.通过采用多种二维固体核磁共振(SSNMR)及原位质子NMR技术,证明了AlV能够大量富集在ASAs表面,着重介绍了两种基于AlV的新B酸位的形成机制,并阐明了AlV诱导单原子催化剂在ASAs表面形成的机理. 展开更多
关键词 固体核磁共振(SSNMR) 无定型硅铝固体酸催化剂 五配位铝 结构-酸性关系 固体酸催化
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