To evaluate the psychometric properties of a newly developed questionnaire, known as the gastroesophageal reflux and dyspepsia therapeutic efficacy and satisfaction test (GERD-TEST), in patients with GERD.METHODSJapan...To evaluate the psychometric properties of a newly developed questionnaire, known as the gastroesophageal reflux and dyspepsia therapeutic efficacy and satisfaction test (GERD-TEST), in patients with GERD.METHODSJapanese patients with predominant GERD symptoms recruited according to the Montreal definition were treated for 4 wk using a standard dose of proton pump inhibitor (PPI). The GERD-TEST and the Medical Outcome Study Short Form-8 Health Survey (SF-8) were administered at baseline and after 4 wk of treatment. The GERD-TEST contains three domains: the severity of GERD and functional dyspepsia (FD) symptoms (5 items), the level of dissatisfaction with daily life (DS) (4 items), and the therapeutic efficacy as assessed by the patients and medication compliance (4 items).RESULTSA total of 290 patients were eligible at baseline; 198 of these patients completed 4 wk of PPI therapy. The internal consistency reliability as evaluated using the Cronbach’s α values for the GERD, FD and DS subscales ranged from 0.75 to 0.82. The scores for the GERD, FD and DS items/subscales were significantly correlated with the physical and mental component summary scores of the SF-8. After 4 wk of PPI treatment, the scores for the GERD items/subscales were greatly reduced, ranging in value from 1.51 to 1.87 and with a large effect size (P < 0.0001, Cohen’s d; 1.29-1.63). Statistically significant differences in the changes in the scores for the GERD items/subscales were observed between treatment responders and non-responders (P < 0.0001).CONCLUSIONThe GERD-TEST has a good reliability, a good convergent and concurrent validity, and is responsive to the effects of treatment. The GERD-TEST is a simple, easy to understand, and multifaceted PRO instrument applicable to both clinical trials and the primary care of GERD patients.展开更多
In clinic＇s appointment scheduling system no-shows have been a significant and confirmed issue with a bad influence on patient accessibility and clinic efficiency. The problem of walk-in has often been seen as the op...In clinic＇s appointment scheduling system no-shows have been a significant and confirmed issue with a bad influence on patient accessibility and clinic efficiency. The problem of walk-in has often been seen as the opposite of no-show problem. In this work we revisit a walk-in admitting based approach to mitigate the bad influence of no-show without overbooking. First we establish a model which utilizes marginal benefit objective function to balance the interests of the clinic, the patient and the doctor, we prove that no-show and walk-in cancels out each other straightly has a bad property. Then we propose a new rule which is an extension of the well-known Bailey - Welch rule, the simulation results show that our rule has an improvement comparing with the common rule that cancels them out straightly.展开更多
[目的]分析影响颈椎后纵韧带骨化症(ossification of the posterior longitudinal ligament,OPLL)单开门椎板成形术疗效的相关因素。[方法]回顾性分析2015年—2022年于宁夏医科大学总医院行C_(3)~C_(7)单开门术的67例颈椎OPLL患者的临...[目的]分析影响颈椎后纵韧带骨化症(ossification of the posterior longitudinal ligament,OPLL)单开门椎板成形术疗效的相关因素。[方法]回顾性分析2015年—2022年于宁夏医科大学总医院行C_(3)~C_(7)单开门术的67例颈椎OPLL患者的临床资料。采用单因素比较、多因素Logistic回归分析和列线图预测模型分析影响OPLL的相关因素。[结果]所有患者顺利完成手术,随访24个月以上。按末次随访时JOA评分改善率<60%或≥60%,33例列为不佳组,占49.3%;34例列为良好组,占50.7%。不佳组年龄[(59.1±9.9)岁vs (52.9±9.8)岁,P=0.010]、椎管占位率[(50.1±15.2)%vs (41.7±12.2)%,P=0.036]、T_(1)倾斜角(T_(1)slop,T_(1)S)[(26.8±8.7)°vs (21.5±5.8)°,P=0.013]、K线阴性比率[-/+,(11/22) vs (4/30),P=0.034]和髓内高信号比率[是/否,(20/13) vs(10/24),P=0.010]均显著大于良好组。多因素逻辑回归分析显示,椎管占位率(OR=83.54,P=0.006)、髓内明显高信号(OR=3.13,P=0.004)、T_(1)S (OR=1.11,P=0.036)是临床疗效不佳的独立危险因素。预测模型ROC曲线下面积为AUC=0.80 (95%CI 0.70~0.91,P<0.001),校准曲线斜率接近1,表明该预测模型准确性良好。[结论]椎管占位率高、髓内信号强度、T_(1)S大是影响手术疗效不佳的独立危险因素。展开更多
基金Supported by Financial support for this clinical study was provided by GERD Society(Osaka,Japan)
文摘To evaluate the psychometric properties of a newly developed questionnaire, known as the gastroesophageal reflux and dyspepsia therapeutic efficacy and satisfaction test (GERD-TEST), in patients with GERD.METHODSJapanese patients with predominant GERD symptoms recruited according to the Montreal definition were treated for 4 wk using a standard dose of proton pump inhibitor (PPI). The GERD-TEST and the Medical Outcome Study Short Form-8 Health Survey (SF-8) were administered at baseline and after 4 wk of treatment. The GERD-TEST contains three domains: the severity of GERD and functional dyspepsia (FD) symptoms (5 items), the level of dissatisfaction with daily life (DS) (4 items), and the therapeutic efficacy as assessed by the patients and medication compliance (4 items).RESULTSA total of 290 patients were eligible at baseline; 198 of these patients completed 4 wk of PPI therapy. The internal consistency reliability as evaluated using the Cronbach’s α values for the GERD, FD and DS subscales ranged from 0.75 to 0.82. The scores for the GERD, FD and DS items/subscales were significantly correlated with the physical and mental component summary scores of the SF-8. After 4 wk of PPI treatment, the scores for the GERD items/subscales were greatly reduced, ranging in value from 1.51 to 1.87 and with a large effect size (P < 0.0001, Cohen’s d; 1.29-1.63). Statistically significant differences in the changes in the scores for the GERD items/subscales were observed between treatment responders and non-responders (P < 0.0001).CONCLUSIONThe GERD-TEST has a good reliability, a good convergent and concurrent validity, and is responsive to the effects of treatment. The GERD-TEST is a simple, easy to understand, and multifaceted PRO instrument applicable to both clinical trials and the primary care of GERD patients.
文摘In clinic＇s appointment scheduling system no-shows have been a significant and confirmed issue with a bad influence on patient accessibility and clinic efficiency. The problem of walk-in has often been seen as the opposite of no-show problem. In this work we revisit a walk-in admitting based approach to mitigate the bad influence of no-show without overbooking. First we establish a model which utilizes marginal benefit objective function to balance the interests of the clinic, the patient and the doctor, we prove that no-show and walk-in cancels out each other straightly has a bad property. Then we propose a new rule which is an extension of the well-known Bailey - Welch rule, the simulation results show that our rule has an improvement comparing with the common rule that cancels them out straightly.
文摘[目的]分析影响颈椎后纵韧带骨化症(ossification of the posterior longitudinal ligament,OPLL)单开门椎板成形术疗效的相关因素。[方法]回顾性分析2015年—2022年于宁夏医科大学总医院行C_(3)~C_(7)单开门术的67例颈椎OPLL患者的临床资料。采用单因素比较、多因素Logistic回归分析和列线图预测模型分析影响OPLL的相关因素。[结果]所有患者顺利完成手术,随访24个月以上。按末次随访时JOA评分改善率<60%或≥60%,33例列为不佳组,占49.3%;34例列为良好组,占50.7%。不佳组年龄[(59.1±9.9)岁vs (52.9±9.8)岁,P=0.010]、椎管占位率[(50.1±15.2)%vs (41.7±12.2)%,P=0.036]、T_(1)倾斜角(T_(1)slop,T_(1)S)[(26.8±8.7)°vs (21.5±5.8)°,P=0.013]、K线阴性比率[-/+,(11/22) vs (4/30),P=0.034]和髓内高信号比率[是/否,(20/13) vs(10/24),P=0.010]均显著大于良好组。多因素逻辑回归分析显示,椎管占位率(OR=83.54,P=0.006)、髓内明显高信号(OR=3.13,P=0.004)、T_(1)S (OR=1.11,P=0.036)是临床疗效不佳的独立危险因素。预测模型ROC曲线下面积为AUC=0.80 (95%CI 0.70~0.91,P<0.001),校准曲线斜率接近1,表明该预测模型准确性良好。[结论]椎管占位率高、髓内信号强度、T_(1)S大是影响手术疗效不佳的独立危险因素。
