AIM： To analyze the frequency of hereditary non-polyposis colorectal cancer （HNPCC） in Chinese colorectal cancer （CRC） patients, and to discuss the value of microsatellite instability （MSI） and/or immunohistoch...AIM： To analyze the frequency of hereditary non-polyposis colorectal cancer （HNPCC） in Chinese colorectal cancer （CRC） patients, and to discuss the value of microsatellite instability （MSI） and/or immunohistochemistry （IHC） for MSH2/MLH1 protein analysis as pre-screening tests in China. METHODS： The Amsterdam criteria Ⅰ and Ⅱ （clinical diagnosis） and/or germline hMLHI/hMSH2 mutations （genetic diagnosis） were used to classify HNPCC families. Genetic tests, including microsatellite instability, immunohistochemistry for MSH2/MLH1 proteins and hMSH2/hMLH1 genes, were performed in each proband. RESULTS： From July 2000 to June 2004, 1988 patients with colorectal cancer were analysed and 114 CRC patients （5.7%） from 48 families were categorized as having HNPCC, including 76 from 26 families diagnosed clinically and 38 from the other 22 families diagnosed genetically. The sensitivity and specificity of high MSI and IHC for predicting mutations were 100% and 54%, and 79% and 77%, respectively. CONCLUSION： The frequency of HNPCC is approximately 10% among all Chinese CRC cases. The MSI and IHC detections for hMSH2/hMLH1 proteins are reliable prescreening tests for hMLHI/hMSH2 germline mutations in families suspected of having HNPCC.展开更多
OBJECTIVE To study the clinicopathologic characteristics, changes in the nature and incidence of colorectal polyps in the Nanchang area, Jiangxi, Province. METHODS We retrospectively investigated the patients with col...OBJECTIVE To study the clinicopathologic characteristics, changes in the nature and incidence of colorectal polyps in the Nanchang area, Jiangxi, Province. METHODS We retrospectively investigated the patients with colorectal polyps who were diagnosed by colonoscopy and pathology in our hospital from 1990 to 2004. The analysis involved the incidence, average patient age, polyp location and pathological types. We recorded the changes of the polyp clinicopathologic features by comparing the clinicopathologic types of colorectal polyps over fi ve-year periods. RESULTS Of the 21,853 patients who received a colonoscopy, 2,889(13.2%) were diagnosed with colorectal polyps. Their average age was 46.6±16.5 years, with a male to female ratio of 1.8:1. The males were older than females (47.1±17.5 vs. 45.5±14.5, P<0.05). Location of the polyps: 41% in the rectum, 27.7% in the sigmoid colon, 35.8% in the left side verus 23.1% in the right side (P<0.05). Patients with polyps located in the transverse and ascending colon were older than those with polyps in the rectum and sigmoid colon (P<0.05). Adenomatous polyps comprised the most common type (67%) and the rectum was the most common site for each type, especially juvenile and retention polyps. Juvenile polyps were found in the youngest patients(12±4.8, P<0.05) and the adenomatous in the oldest (52±14, P<0.05). The ratio of patients with polyposis comprised 1.2%, and patients with polyps accompanied with colorectal cancer comprised 6.1%. Examination of the changes in the incidence, the average patient age, and adenomatous type showed that they had all increased, but the frequency of infl ammatory and retention polyps decreased. CONCLUSION Colorectal polyps are a common problem. The frequency is greater in males compared to females and the rectum and sigmoid colon had the highest incidence. Most juvenile and retention polyps were found in young patients, but most adenomatous occurred in adults. In recent years, the incidence of colorectal polyps, the average patient age, and the adenomatous type have increased in the Nanchang area, but inflammatory and retention types decreased.展开更多
基金Supported in part by Tianjin Science Grant,China
文摘AIM： To analyze the frequency of hereditary non-polyposis colorectal cancer （HNPCC） in Chinese colorectal cancer （CRC） patients, and to discuss the value of microsatellite instability （MSI） and/or immunohistochemistry （IHC） for MSH2/MLH1 protein analysis as pre-screening tests in China. METHODS： The Amsterdam criteria Ⅰ and Ⅱ （clinical diagnosis） and/or germline hMLHI/hMSH2 mutations （genetic diagnosis） were used to classify HNPCC families. Genetic tests, including microsatellite instability, immunohistochemistry for MSH2/MLH1 proteins and hMSH2/hMLH1 genes, were performed in each proband. RESULTS： From July 2000 to June 2004, 1988 patients with colorectal cancer were analysed and 114 CRC patients （5.7%） from 48 families were categorized as having HNPCC, including 76 from 26 families diagnosed clinically and 38 from the other 22 families diagnosed genetically. The sensitivity and specificity of high MSI and IHC for predicting mutations were 100% and 54%, and 79% and 77%, respectively. CONCLUSION： The frequency of HNPCC is approximately 10% among all Chinese CRC cases. The MSI and IHC detections for hMSH2/hMLH1 proteins are reliable prescreening tests for hMLHI/hMSH2 germline mutations in families suspected of having HNPCC.
文摘OBJECTIVE To study the clinicopathologic characteristics, changes in the nature and incidence of colorectal polyps in the Nanchang area, Jiangxi, Province. METHODS We retrospectively investigated the patients with colorectal polyps who were diagnosed by colonoscopy and pathology in our hospital from 1990 to 2004. The analysis involved the incidence, average patient age, polyp location and pathological types. We recorded the changes of the polyp clinicopathologic features by comparing the clinicopathologic types of colorectal polyps over fi ve-year periods. RESULTS Of the 21,853 patients who received a colonoscopy, 2,889(13.2%) were diagnosed with colorectal polyps. Their average age was 46.6±16.5 years, with a male to female ratio of 1.8:1. The males were older than females (47.1±17.5 vs. 45.5±14.5, P<0.05). Location of the polyps: 41% in the rectum, 27.7% in the sigmoid colon, 35.8% in the left side verus 23.1% in the right side (P<0.05). Patients with polyps located in the transverse and ascending colon were older than those with polyps in the rectum and sigmoid colon (P<0.05). Adenomatous polyps comprised the most common type (67%) and the rectum was the most common site for each type, especially juvenile and retention polyps. Juvenile polyps were found in the youngest patients(12±4.8, P<0.05) and the adenomatous in the oldest (52±14, P<0.05). The ratio of patients with polyposis comprised 1.2%, and patients with polyps accompanied with colorectal cancer comprised 6.1%. Examination of the changes in the incidence, the average patient age, and adenomatous type showed that they had all increased, but the frequency of infl ammatory and retention polyps decreased. CONCLUSION Colorectal polyps are a common problem. The frequency is greater in males compared to females and the rectum and sigmoid colon had the highest incidence. Most juvenile and retention polyps were found in young patients, but most adenomatous occurred in adults. In recent years, the incidence of colorectal polyps, the average patient age, and the adenomatous type have increased in the Nanchang area, but inflammatory and retention types decreased.
