AIM： In the present study, antibody and peripheral blood mononuclear cells （PBMC） proliferative responses against hepatitis C virus （HCV） antigens were evaluated in HCV chronically infected patients. METHODS： Pa...AIM： In the present study, antibody and peripheral blood mononuclear cells （PBMC） proliferative responses against hepatitis C virus （HCV） antigens were evaluated in HCV chronically infected patients. METHODS： Paired serum and PBMC samples were taken six months apart from 34 individuals, either treated or not, and tested by enzyme-linked immunosorbent assay （ELISA） and carboxyfluorescein succinimidyl ester staining. RSULTS： Over 70% of the patients showed specific IgG and IgM against capsid, E1 and NS3, while HVR-1 was recognized by half of the patients. An increase in the levels of the anti-capsid IgM （P = 0.027） and IgG （P = 0.0006） was observed in six-month samples, compared to baseline. Similarly, a significantly higher percent of patients had detectable IgA reactivity to capsid （P = 0.017） and NS3 （P = 0.005） after six months, compared to baseline. Particularly, IgA against structural antigens positively correlated with hepatic damage （P = 0.036）. IgG subclasses evaluation against capsid and NS3 revealed a positive recognition mediated by IgG1 in more than 80% of the individuals. On the contrary, less than 30% of the patients showed a positive proliferative response either of CD4＋ or CD8＋ T cells, being the capsid poorly recognized. CONCLUSION： These results confirm that while the cellular immune response is narrow and weak, a broad and vigorous humoral response occurs in HCV chronic infection. The observed correlation between IgA and hepatic damage may have diagnostic significance, although it warrants further confirmation.展开更多
Due to the substantial role of bridges in transportation networks and in accordance with the limited funding for bridge management, remediation strategies have to be prioritised. A conservative bridge assessment will ...Due to the substantial role of bridges in transportation networks and in accordance with the limited funding for bridge management, remediation strategies have to be prioritised. A conservative bridge assessment will result in unnecessary actions, such as costly bridge strengthening or repairs. On the other hand, any bridge maintenance negligence and delayed actions may lead to heavy future costs or degraded assets. The accuracy of decisions developed by any manager or bridge engineer relies on the accuracy of the bridge condition assessment which emanates from visual inspection. Many bridge rating systems are based on a very subjective procedure and are associated with uncertainty and personal bias. The developing condition rating method described herein is an important step in adding more holism and objectivity to the current approaches. Structural importance and material vulnerability are the two main factors that should be considered in the evaluation of element structural index and the causal factor as the representative of age, environment, road class and inspection is implemented as a coefficient to the OSCI （overall structural condition index）. The AHP （analytical hierarchy process） has been applied to evaluate the priority vector of the causal parameters.展开更多
The rule of law is the basic form of national governance and the rule of law model is the necessary direction for the governance of online society.Online society is in essence a new pattern of social relationships and...The rule of law is the basic form of national governance and the rule of law model is the necessary direction for the governance of online society.Online society is in essence a new pattern of social relationships and structural forms comprising relationships among citizens,legal persons,organizational bodies,etc.,formed and brought together on the basis of Internet technology;and also a reflection,expansion and expression,singly or in synthesis,of various relationships in the fields of the real economy,politics,culture,society and the environment.The rule of law model of Internet governance refers to governance theories,systems and practices that employ rule of law thinking and the rule of law model to bring the elements,structures,procedures and functions of Internet governance into the scope of the rule of law and its operational track.Reviewing the tortuous course of the development of rule of law Internet governance in China,summarizing useful experience in the construction of rule of law Internet governance,and reflecting on existing legislative,law enforcement and judicial dilemmas will enable us to build up a rule of law system of online governance with comprehensive norms,effective implementation,strict supervision and strong guarantees.This will be marked by Chinese characteristics and will ensure the application of rule of law thinking and the rule of law model in governing,operating,using and safeguarding the Internet,thus achieving sound and orderly Internet operation and development along the path of the rule of law and advancing the modernization of the Internet governance system and governance capability.展开更多
Hemorrhoid refers to soft vein mass formed by varicosity of submucosal veins around the end of the rectum and subcutanceous veins of the anal canal. It is the most common anorectal disease. This article summarized the...Hemorrhoid refers to soft vein mass formed by varicosity of submucosal veins around the end of the rectum and subcutanceous veins of the anal canal. It is the most common anorectal disease. This article summarized the regular patterns, features and advantages of Professor Yu Hai-Bo＇s acupuncture-moxibustion therapy for hemorrhoids, in order to guide the acupuncture treatment for hemorrhoids.展开更多
With his profound knowledge from family education and meticulous scholarship, Prof.HUANG Xian-ming is extremely knowledgeable in Chinese medical art by drawing the advantage from modern medicine.
基金Supported by Grant from Pan American Health Organization, held by Dr. Santiago Dueas-Carrera
文摘AIM： In the present study, antibody and peripheral blood mononuclear cells （PBMC） proliferative responses against hepatitis C virus （HCV） antigens were evaluated in HCV chronically infected patients. METHODS： Paired serum and PBMC samples were taken six months apart from 34 individuals, either treated or not, and tested by enzyme-linked immunosorbent assay （ELISA） and carboxyfluorescein succinimidyl ester staining. RSULTS： Over 70% of the patients showed specific IgG and IgM against capsid, E1 and NS3, while HVR-1 was recognized by half of the patients. An increase in the levels of the anti-capsid IgM （P = 0.027） and IgG （P = 0.0006） was observed in six-month samples, compared to baseline. Similarly, a significantly higher percent of patients had detectable IgA reactivity to capsid （P = 0.017） and NS3 （P = 0.005） after six months, compared to baseline. Particularly, IgA against structural antigens positively correlated with hepatic damage （P = 0.036）. IgG subclasses evaluation against capsid and NS3 revealed a positive recognition mediated by IgG1 in more than 80% of the individuals. On the contrary, less than 30% of the patients showed a positive proliferative response either of CD4＋ or CD8＋ T cells, being the capsid poorly recognized. CONCLUSION： These results confirm that while the cellular immune response is narrow and weak, a broad and vigorous humoral response occurs in HCV chronic infection. The observed correlation between IgA and hepatic damage may have diagnostic significance, although it warrants further confirmation.
文摘Due to the substantial role of bridges in transportation networks and in accordance with the limited funding for bridge management, remediation strategies have to be prioritised. A conservative bridge assessment will result in unnecessary actions, such as costly bridge strengthening or repairs. On the other hand, any bridge maintenance negligence and delayed actions may lead to heavy future costs or degraded assets. The accuracy of decisions developed by any manager or bridge engineer relies on the accuracy of the bridge condition assessment which emanates from visual inspection. Many bridge rating systems are based on a very subjective procedure and are associated with uncertainty and personal bias. The developing condition rating method described herein is an important step in adding more holism and objectivity to the current approaches. Structural importance and material vulnerability are the two main factors that should be considered in the evaluation of element structural index and the causal factor as the representative of age, environment, road class and inspection is implemented as a coefficient to the OSCI （overall structural condition index）. The AHP （analytical hierarchy process） has been applied to evaluate the priority vector of the causal parameters.
基金the phased result of the special project “An Original Jurisprudence Theory of Social Governance”(Grant No.:16@ZH024)of the National Social Science Fund of China
文摘The rule of law is the basic form of national governance and the rule of law model is the necessary direction for the governance of online society.Online society is in essence a new pattern of social relationships and structural forms comprising relationships among citizens,legal persons,organizational bodies,etc.,formed and brought together on the basis of Internet technology;and also a reflection,expansion and expression,singly or in synthesis,of various relationships in the fields of the real economy,politics,culture,society and the environment.The rule of law model of Internet governance refers to governance theories,systems and practices that employ rule of law thinking and the rule of law model to bring the elements,structures,procedures and functions of Internet governance into the scope of the rule of law and its operational track.Reviewing the tortuous course of the development of rule of law Internet governance in China,summarizing useful experience in the construction of rule of law Internet governance,and reflecting on existing legislative,law enforcement and judicial dilemmas will enable us to build up a rule of law system of online governance with comprehensive norms,effective implementation,strict supervision and strong guarantees.This will be marked by Chinese characteristics and will ensure the application of rule of law thinking and the rule of law model in governing,operating,using and safeguarding the Internet,thus achieving sound and orderly Internet operation and development along the path of the rule of law and advancing the modernization of the Internet governance system and governance capability.
基金supported by Key Laboratory Project of Shenzhen Science and Technology Research and Development Funds and Platform Construction Planning,No.CXB201111250113A~~
文摘Hemorrhoid refers to soft vein mass formed by varicosity of submucosal veins around the end of the rectum and subcutanceous veins of the anal canal. It is the most common anorectal disease. This article summarized the regular patterns, features and advantages of Professor Yu Hai-Bo＇s acupuncture-moxibustion therapy for hemorrhoids, in order to guide the acupuncture treatment for hemorrhoids.
文摘With his profound knowledge from family education and meticulous scholarship, Prof.HUANG Xian-ming is extremely knowledgeable in Chinese medical art by drawing the advantage from modern medicine.
