Genomic sequences have been determined for a number of strains of Helicobacter pylori （H pylori） and related bacteria. With the development of microarray analysis and the wide use of subtractive hybridization techni...Genomic sequences have been determined for a number of strains of Helicobacter pylori （H pylori） and related bacteria. With the development of microarray analysis and the wide use of subtractive hybridization techniques, comparative studies have been carried out with respect to the interstrain differences between H pylori and inter-species differences in the genome of related bacteria. It was found that the core genome of H pylori constitutes 1111 genes that are determinants of the species properties. A great pool of auxiliary genes are mainly from the categories of cag pathogenicity islands, outer membrane proteins, restriction-modification system and hypothetical proteins of unknown function. Persistence of H pylori in the human stomach leads to the diversification of the genome. Comparative genomics suggest that a host jump has occurs from humans to felines. Candidate genes specific for the development of the gastric diseases were identified. With the aid of proteomics, population genetics and other molecular methods, future comparative genomic studies would dramatically promote our understanding of the evolution, pathogenesis and microbiology of Hpylori.展开更多
Based on the 1983~2011 CMAP data,the precipitation anomaly in East Asia and its nearby sea regions（hereafter called East Asia for short） demonstrates the ＂＋-＋＂ pattern before 1999 and the ＂-＋-＂ pattern afterw...Based on the 1983~2011 CMAP data,the precipitation anomaly in East Asia and its nearby sea regions（hereafter called East Asia for short） demonstrates the ＂＋-＋＂ pattern before 1999 and the ＂-＋-＂ pattern afterwards; this decadal change is contained principally in the corresponding EOF3 component.However,the NCC_CGCM forecast results are quite different,which reveal the ＂＋-＋-＂ pattern before 1999 and the ＂-＋-＋＂ pattern afterwards.Meanwhile,the probability of improving NCC_CGCM＇s forecast accuracy based on these key SST areas is discussed,and the dynamic-statistics combined forecast scheme is constructed for increasing the information of decadal change contained in the summer precipitation in East Asia.The independent sample forecast results indicate that this forecasting scheme can effectively modify the NCC_CGCM＇s decadal change information contained in the summer precipitation in East Asia（especially in the area of 30°N–55°N）.The ACC is 0.25 and ACR is 61% for the forecasting result based on the V SST area,and the mean ACC is 0.03 and ACR is 51% for the seven key areas,which are better than NCC_CGCM＇s system error correction results（ACC is -0.01 and ACR is 49%）.Besides,the modified forecast results also provide the information that the precipitation anomaly in East Asia mainly shows the ＂＋-＋＂ pattern before 1999 and the ＂-＋-＂ pattern afterwards.展开更多
文摘Genomic sequences have been determined for a number of strains of Helicobacter pylori （H pylori） and related bacteria. With the development of microarray analysis and the wide use of subtractive hybridization techniques, comparative studies have been carried out with respect to the interstrain differences between H pylori and inter-species differences in the genome of related bacteria. It was found that the core genome of H pylori constitutes 1111 genes that are determinants of the species properties. A great pool of auxiliary genes are mainly from the categories of cag pathogenicity islands, outer membrane proteins, restriction-modification system and hypothetical proteins of unknown function. Persistence of H pylori in the human stomach leads to the diversification of the genome. Comparative genomics suggest that a host jump has occurs from humans to felines. Candidate genes specific for the development of the gastric diseases were identified. With the aid of proteomics, population genetics and other molecular methods, future comparative genomic studies would dramatically promote our understanding of the evolution, pathogenesis and microbiology of Hpylori.
基金supported by the National Basic Research Program of China(Grant No.2012CB955203)the National Natural Science Foundation of China(Grant Nos.41205040,41105055)the Special Scientific Research Project for Public Interest(Grant No.GYHY201306021)
文摘Based on the 1983~2011 CMAP data,the precipitation anomaly in East Asia and its nearby sea regions（hereafter called East Asia for short） demonstrates the ＂＋-＋＂ pattern before 1999 and the ＂-＋-＂ pattern afterwards; this decadal change is contained principally in the corresponding EOF3 component.However,the NCC_CGCM forecast results are quite different,which reveal the ＂＋-＋-＂ pattern before 1999 and the ＂-＋-＋＂ pattern afterwards.Meanwhile,the probability of improving NCC_CGCM＇s forecast accuracy based on these key SST areas is discussed,and the dynamic-statistics combined forecast scheme is constructed for increasing the information of decadal change contained in the summer precipitation in East Asia.The independent sample forecast results indicate that this forecasting scheme can effectively modify the NCC_CGCM＇s decadal change information contained in the summer precipitation in East Asia（especially in the area of 30°N–55°N）.The ACC is 0.25 and ACR is 61% for the forecasting result based on the V SST area,and the mean ACC is 0.03 and ACR is 51% for the seven key areas,which are better than NCC_CGCM＇s system error correction results（ACC is -0.01 and ACR is 49%）.Besides,the modified forecast results also provide the information that the precipitation anomaly in East Asia mainly shows the ＂＋-＋＂ pattern before 1999 and the ＂-＋-＂ pattern afterwards.
