By means of theory of toplogical degree in nonlinear functional analysis combining with qualitative analysis method in ordinary differential equations, we discuss the existence of nontrivial periodic orbits for higher...By means of theory of toplogical degree in nonlinear functional analysis combining with qualitative analysis method in ordinary differential equations, we discuss the existence of nontrivial periodic orbits for higher dimensional autonomous system with small perturbations.展开更多
AIM:To evaluate safety and effect on hepatitis B virus(HBV)suppression of a long-term treatment with lamivudine(LAM)at standard(100 mg/d)or double(200 mg/d)dose in chronic hepatitis B.METHODS:This was a case study wit...AIM:To evaluate safety and effect on hepatitis B virus(HBV)suppression of a long-term treatment with lamivudine(LAM)at standard(100 mg/d)or double(200 mg/d)dose in chronic hepatitis B.METHODS:This was a case study with matched controls(1:3)in patients with chronic hepatitis B with anti-HBe antibodies.RESULTS:Twelve patients received LAM 200 mg/d and 35 LAM 100 mg/d,for a median of 28 mo.A primary response(PR;i.e.negative HBV-DNA with Amplicor assay)was achieved in 100% of LAM-200 patients and 83% of LAM-100 patients.A virological breakthrough occurred in 16.7 and 24.7%,respectively,of the PR-patients,with the appearance of typical LAM resistance mutations in all but one patient.Viremia blips(i.e.transient HBV-DNA below 80 IU/mL in patients who tested negative at Amplicor assay)were detected using a real time polymerase chain reaction(PCR)and occurred in seven out of nine patients with subsequent BT and in four out of 32 patients with end-of-study response(77.7% vs 12.5%;P = 0.001)at chi-square test).At the end of the study,51.4% of LAM-100 patients and 83.3% of LAM-200 patients had remained stably HBV-DNA negative.Double-dose LAM was well tolerated.CONCLUSION:Long-term treatment of anti-HBe positive chronic hepatitis B with double dose lamivudine causes a more profound and stable viral suppression ascompared to conventional treatment.展开更多
The substantive characteristics of the connotation of ＂State＂ include two parts： （I） the relatively perpetual and impersonalized political system; （II） the ductility of organization forms within the space and p...The substantive characteristics of the connotation of ＂State＂ include two parts： （I） the relatively perpetual and impersonalized political system; （II） the ductility of organization forms within the space and politics. And the later part is the absolute attribute of this connotation while the former part tends to show with different forms. Therefore, it is more suitable for the former one to be the objective for study on the evolution process of the connotation of ＂State＂ at different stages. Based on this understanding, the author discusses the specific political system at different stages and the relatively perpetual and impersonalized methods for the realization of the system, then tries to define the connotation of the early state, ancient state and modem state in Chinese history.展开更多
In the coming years life expectancy is expected to increase and with this the percentage of the population above age 65 will grow. Patients above 65 make up more than two thirds of those currently diagnosed with gastr...In the coming years life expectancy is expected to increase and with this the percentage of the population above age 65 will grow. Patients above 65 make up more than two thirds of those currently diagnosed with gastrointestinal malignancies. Available evidence based medicine does not focus on the average patient, above the age 70, encountered in every day practice. Most guidelines and clinical trials are not designed to take into account the special considerations needed when treating the elderly such as functional status, comorbidities, polypharmacy, life expectancy, and social support. The majority of available data is based on retrospective reviews or subset analyses of larger studies where the elderly represent a fraction of the studied population. This review focuses on the toxicities and tolerability of current standard therapies for noncolorectal gastrointestinal malignancies, including gastroesophageal, pancreatic, bile duct and hepatocellular cancers in the elderly. With careful patient selection and geriatric assessment the elderly can safely benefit from standard therapies offered to younger patients.展开更多
This report describes the case of a patient with dysarthria during the administration of the third cycle of Folfu＇i for the treatment of metastatic colon cancer. After a thorough neurological examination and neuroima...This report describes the case of a patient with dysarthria during the administration of the third cycle of Folfu＇i for the treatment of metastatic colon cancer. After a thorough neurological examination and neuroimaging, structural causes were excluded and thus the dysarthria was attributed to the irinotecan infusion. A slowing down of the infusion rate to 180 min during the 15 subsequent cycles led to the cessation of the episodes of dysarthria. In 2016, it was estimated there will be 134,490 new cases of colorectal cancer with a five-year survival rate of 21% among patients with metastatic disease. As Irinotecan is often part of the therapeutic regimen in such cases, both in the first and second-line setting, there is a need to report rare adverse outcomes in order to fmd out ways to better manage of these events. The mechanism by which Irinotecan causes dysarthria is unknown and further research in this area is warranted.展开更多
By means of theory of topological degree in nonlinear functional analysiscombining with qualitative analysis in ordinary differential equations, we discuss theexistence of nontrivial periodic orbits to a higher di...By means of theory of topological degree in nonlinear functional analysiscombining with qualitative analysis in ordinary differential equations, we discuss theexistence of nontrivial periodic orbits to a higher dimensional autonomous system witha non-hyperbolic singular point.展开更多
The travelling wave solutions of a generalized Camassa-Holm-Degasperis-Procesi equation ut-uxxt + (1 + b)umux = buxuxx + uuxxx are considered where b > 1 and m are positive integers. The qualitative analysis method...The travelling wave solutions of a generalized Camassa-Holm-Degasperis-Procesi equation ut-uxxt + (1 + b)umux = buxuxx + uuxxx are considered where b > 1 and m are positive integers. The qualitative analysis methods of planar autonomous systems yield its phase portraits. Its soliton wave solutions, kink or antikink wave solutions, peakon wave solutions, compacton wave solutions, periodic wave solutions and periodic cusp wave solutions are obtained. Some numerical simulations of these solutions are also given.展开更多
Purpose： Early intramedullary nailing （IMN） within the first 24 h for multiply injured patients with femoral fracture and concomitant thoracic trauma is controversial. Previously published studies have been limited...Purpose： Early intramedullary nailing （IMN） within the first 24 h for multiply injured patients with femoral fracture and concomitant thoracic trauma is controversial. Previously published studies have been limited in size and their outcomes have been inconclusive. A meta-analysis was conducted to evaluate the available data in order to guide care and help improve the outcomes for these patients. Methods： We searched the literature up to December 2011 in the main medical search engines and identified 6 retrospective cohort studies that explored the safety of early IMN in patients with both femoral fracture and chest injury. Our primary outcome was the rates of pulmonary complication （pneumonia, adult respiratory distress syndrome, fat embolism syndrome）, multiple organ failure （MOF） and mortality. Results： We found no statistically significant difference in the rate of pulmonary complications, MOF or mortality in the patients treated with early IMN. Conclusion： Early 1MN for femoral fractures does not increase the mortality and morbidity in chest- iniured patients in the studies anah/zed.展开更多
In this paper, a class of nonautonomous Lotka-Volterra type multispecies competitive systems with delays is studied. By employing Lyapunov functional, some sufficient conditions to guarantee the existence of almost pe...In this paper, a class of nonautonomous Lotka-Volterra type multispecies competitive systems with delays is studied. By employing Lyapunov functional, some sufficient conditions to guarantee the existence of almost periodic solutions for the Lotka-Volterra system are obtained.展开更多
This paper presents a simple and rigorous solution procedure of residue harmonic balance for predicting the accurate approximation of certain autonomous ordinary differential systems.In this solution procedure,no smal...This paper presents a simple and rigorous solution procedure of residue harmonic balance for predicting the accurate approximation of certain autonomous ordinary differential systems.In this solution procedure,no small parameter is assumed.The harmonic residue of balance equation is separated in two parts at each step.The first part has the same number of Fourier terms as the present order of approximation and the remaining part is used in the subsequent improvement.The corrections are governed by linear ordinary differential equation so that they can be solved easily by means of harmonic balance method again.Three kinds of different differential equations involving general,fractional and delay ordinary differential systems are given as numerical examples respectively.Highly accurate limited cycle frequency and amplitude are captured.The results match well with the exact solutions or numerical solutions for a wide range of control parameters.Comparison with those available shows that the residue harmonic balance solution procedure is very effective for these autonomous differential systems.Moreover,the present method works not only in predicting the amplitude but also the frequency of bifurcated period solution for delay ordinary differential equation.展开更多
文摘By means of theory of toplogical degree in nonlinear functional analysis combining with qualitative analysis method in ordinary differential equations, we discuss the existence of nontrivial periodic orbits for higher dimensional autonomous system with small perturbations.
文摘AIM:To evaluate safety and effect on hepatitis B virus(HBV)suppression of a long-term treatment with lamivudine(LAM)at standard(100 mg/d)or double(200 mg/d)dose in chronic hepatitis B.METHODS:This was a case study with matched controls(1:3)in patients with chronic hepatitis B with anti-HBe antibodies.RESULTS:Twelve patients received LAM 200 mg/d and 35 LAM 100 mg/d,for a median of 28 mo.A primary response(PR;i.e.negative HBV-DNA with Amplicor assay)was achieved in 100% of LAM-200 patients and 83% of LAM-100 patients.A virological breakthrough occurred in 16.7 and 24.7%,respectively,of the PR-patients,with the appearance of typical LAM resistance mutations in all but one patient.Viremia blips(i.e.transient HBV-DNA below 80 IU/mL in patients who tested negative at Amplicor assay)were detected using a real time polymerase chain reaction(PCR)and occurred in seven out of nine patients with subsequent BT and in four out of 32 patients with end-of-study response(77.7% vs 12.5%;P = 0.001)at chi-square test).At the end of the study,51.4% of LAM-100 patients and 83.3% of LAM-200 patients had remained stably HBV-DNA negative.Double-dose LAM was well tolerated.CONCLUSION:Long-term treatment of anti-HBe positive chronic hepatitis B with double dose lamivudine causes a more profound and stable viral suppression ascompared to conventional treatment.
文摘The substantive characteristics of the connotation of ＂State＂ include two parts： （I） the relatively perpetual and impersonalized political system; （II） the ductility of organization forms within the space and politics. And the later part is the absolute attribute of this connotation while the former part tends to show with different forms. Therefore, it is more suitable for the former one to be the objective for study on the evolution process of the connotation of ＂State＂ at different stages. Based on this understanding, the author discusses the specific political system at different stages and the relatively perpetual and impersonalized methods for the realization of the system, then tries to define the connotation of the early state, ancient state and modem state in Chinese history.
文摘In the coming years life expectancy is expected to increase and with this the percentage of the population above age 65 will grow. Patients above 65 make up more than two thirds of those currently diagnosed with gastrointestinal malignancies. Available evidence based medicine does not focus on the average patient, above the age 70, encountered in every day practice. Most guidelines and clinical trials are not designed to take into account the special considerations needed when treating the elderly such as functional status, comorbidities, polypharmacy, life expectancy, and social support. The majority of available data is based on retrospective reviews or subset analyses of larger studies where the elderly represent a fraction of the studied population. This review focuses on the toxicities and tolerability of current standard therapies for noncolorectal gastrointestinal malignancies, including gastroesophageal, pancreatic, bile duct and hepatocellular cancers in the elderly. With careful patient selection and geriatric assessment the elderly can safely benefit from standard therapies offered to younger patients.
文摘This report describes the case of a patient with dysarthria during the administration of the third cycle of Folfu＇i for the treatment of metastatic colon cancer. After a thorough neurological examination and neuroimaging, structural causes were excluded and thus the dysarthria was attributed to the irinotecan infusion. A slowing down of the infusion rate to 180 min during the 15 subsequent cycles led to the cessation of the episodes of dysarthria. In 2016, it was estimated there will be 134,490 new cases of colorectal cancer with a five-year survival rate of 21% among patients with metastatic disease. As Irinotecan is often part of the therapeutic regimen in such cases, both in the first and second-line setting, there is a need to report rare adverse outcomes in order to fmd out ways to better manage of these events. The mechanism by which Irinotecan causes dysarthria is unknown and further research in this area is warranted.
文摘By means of theory of topological degree in nonlinear functional analysiscombining with qualitative analysis in ordinary differential equations, we discuss theexistence of nontrivial periodic orbits to a higher dimensional autonomous system witha non-hyperbolic singular point.
基金supported by China Postdoctoral Science Foundation (Grant Nos. 20100470249, 20100470254)
文摘The travelling wave solutions of a generalized Camassa-Holm-Degasperis-Procesi equation ut-uxxt + (1 + b)umux = buxuxx + uuxxx are considered where b > 1 and m are positive integers. The qualitative analysis methods of planar autonomous systems yield its phase portraits. Its soliton wave solutions, kink or antikink wave solutions, peakon wave solutions, compacton wave solutions, periodic wave solutions and periodic cusp wave solutions are obtained. Some numerical simulations of these solutions are also given.
文摘Purpose： Early intramedullary nailing （IMN） within the first 24 h for multiply injured patients with femoral fracture and concomitant thoracic trauma is controversial. Previously published studies have been limited in size and their outcomes have been inconclusive. A meta-analysis was conducted to evaluate the available data in order to guide care and help improve the outcomes for these patients. Methods： We searched the literature up to December 2011 in the main medical search engines and identified 6 retrospective cohort studies that explored the safety of early IMN in patients with both femoral fracture and chest injury. Our primary outcome was the rates of pulmonary complication （pneumonia, adult respiratory distress syndrome, fat embolism syndrome）, multiple organ failure （MOF） and mortality. Results： We found no statistically significant difference in the rate of pulmonary complications, MOF or mortality in the patients treated with early IMN. Conclusion： Early 1MN for femoral fractures does not increase the mortality and morbidity in chest- iniured patients in the studies anah/zed.
基金This research was supported by the National Natural Science Foundation of China under Grant 11361010.
文摘In this paper, a class of nonautonomous Lotka-Volterra type multispecies competitive systems with delays is studied. By employing Lyapunov functional, some sufficient conditions to guarantee the existence of almost periodic solutions for the Lotka-Volterra system are obtained.
基金supported by the Natural Science Foundation of Shandong Province,China(Grant Nos.ZR2011AQ022 and ZR2012AL03)
文摘This paper presents a simple and rigorous solution procedure of residue harmonic balance for predicting the accurate approximation of certain autonomous ordinary differential systems.In this solution procedure,no small parameter is assumed.The harmonic residue of balance equation is separated in two parts at each step.The first part has the same number of Fourier terms as the present order of approximation and the remaining part is used in the subsequent improvement.The corrections are governed by linear ordinary differential equation so that they can be solved easily by means of harmonic balance method again.Three kinds of different differential equations involving general,fractional and delay ordinary differential systems are given as numerical examples respectively.Highly accurate limited cycle frequency and amplitude are captured.The results match well with the exact solutions or numerical solutions for a wide range of control parameters.Comparison with those available shows that the residue harmonic balance solution procedure is very effective for these autonomous differential systems.Moreover,the present method works not only in predicting the amplitude but also the frequency of bifurcated period solution for delay ordinary differential equation.
