AIMS Using a new approach of regional adjuvant chemotherapy to prevent cancer cells hepatic metasta- sis after radical surgery of large bowel cancer. METHODS A model of liver with metastasis of hu- man colonic cancer ...AIMS Using a new approach of regional adjuvant chemotherapy to prevent cancer cells hepatic metasta- sis after radical surgery of large bowel cancer. METHODS A model of liver with metastasis of hu- man colonic cancer (HCC) cells in nude mice was used to observe the effect in prevention of metastasis of HCC cells inoculated via spleen applied with early postoper- ative intraperitoneal (IP) chemotherapy using large dose of 5-FU. RESULTS The incidence of metastasis to liver was decreased by 40%,the mean number of metastatic liv- er nodules in each animal was reduced by 50.89% and the mean survival times of each animal was prolonged by 48.21% by using 5-FU 40 mg/NS 40 ml/kg IP for two consecutive days as compared with the controls. CONCLUSIONS IP is a new and more effective re- gional adjuvant chemotheraputic approach in the pre- vention of liver metastasis HCC cells after radical surgery of large bowel cancer.展开更多
目的探讨Weill-Marchesani综合征继发青光眼的手术治疗方法。设计回顾性小样本病例系列。研究对象2009年6月至2010年1月在北京同仁医院住院手术治疗的年龄13~32岁的Weill-Marchesani综合征继发青光眼晚期患者3例。方法 2例为晶状体半脱...目的探讨Weill-Marchesani综合征继发青光眼的手术治疗方法。设计回顾性小样本病例系列。研究对象2009年6月至2010年1月在北京同仁医院住院手术治疗的年龄13~32岁的Weill-Marchesani综合征继发青光眼晚期患者3例。方法 2例为晶状体半脱位继发青光眼,采取晶状体及前部玻璃体切除术联合Ahmed阀植入术或直视下眼内睫状体光凝术。1例为人工晶状体（IOL）眼继发闭角型青光眼,采取Ahmed阀植入术联合前部玻璃体切除术。主要指标眼压。结果术后随访4~6个月。采取Ahmed阀植入术联合手术的2例患者不用药物眼压控制在21 mm Hg以下;采取眼内睫状体光凝术的1例患者局部用2种降眼压药物眼压稳定控制在21 mm Hg以下。1例术后早期发生严重脉络膜脱离,1例术后早期出现恶性青光眼,经保守治疗恢复。结论本文有限的病例结果提示,Weill-Marchesani综合征继发青光眼采用晶状体及前部玻璃体切除术联合青光眼引流阀植入术或眼内睫状体光凝术可有效地控制眼压。展开更多
基金Supported by the National Science Foundation of China,No.39270650
文摘AIMS Using a new approach of regional adjuvant chemotherapy to prevent cancer cells hepatic metasta- sis after radical surgery of large bowel cancer. METHODS A model of liver with metastasis of hu- man colonic cancer (HCC) cells in nude mice was used to observe the effect in prevention of metastasis of HCC cells inoculated via spleen applied with early postoper- ative intraperitoneal (IP) chemotherapy using large dose of 5-FU. RESULTS The incidence of metastasis to liver was decreased by 40%,the mean number of metastatic liv- er nodules in each animal was reduced by 50.89% and the mean survival times of each animal was prolonged by 48.21% by using 5-FU 40 mg/NS 40 ml/kg IP for two consecutive days as compared with the controls. CONCLUSIONS IP is a new and more effective re- gional adjuvant chemotheraputic approach in the pre- vention of liver metastasis HCC cells after radical surgery of large bowel cancer.
文摘目的探讨Weill-Marchesani综合征继发青光眼的手术治疗方法。设计回顾性小样本病例系列。研究对象2009年6月至2010年1月在北京同仁医院住院手术治疗的年龄13~32岁的Weill-Marchesani综合征继发青光眼晚期患者3例。方法 2例为晶状体半脱位继发青光眼,采取晶状体及前部玻璃体切除术联合Ahmed阀植入术或直视下眼内睫状体光凝术。1例为人工晶状体（IOL）眼继发闭角型青光眼,采取Ahmed阀植入术联合前部玻璃体切除术。主要指标眼压。结果术后随访4~6个月。采取Ahmed阀植入术联合手术的2例患者不用药物眼压控制在21 mm Hg以下;采取眼内睫状体光凝术的1例患者局部用2种降眼压药物眼压稳定控制在21 mm Hg以下。1例术后早期发生严重脉络膜脱离,1例术后早期出现恶性青光眼,经保守治疗恢复。结论本文有限的病例结果提示,Weill-Marchesani综合征继发青光眼采用晶状体及前部玻璃体切除术联合青光眼引流阀植入术或眼内睫状体光凝术可有效地控制眼压。
