Purpose:The aim of this research was to explore the benefits of mindfulness-based psychological care(MBPC)and assess whether the intervention would be beneficial in reducing insomnia and emotional symptoms of leukemia...Purpose:The aim of this research was to explore the benefits of mindfulness-based psychological care(MBPC)and assess whether the intervention would be beneficial in reducing insomnia and emotional symptoms of leukemia patients receiving chemotherapy.Methods:A randomized control design study was applied in two hematology departments in a hospital in Zhengzhou.Patients in the experimental group received mindfulness-based psychological care(MBPC),and those in the control group received conventional care.Anxiety,depression,and sleeping problems were measured using the Self-Rating Anxiety Scale,Self-Rating Depression Scale,and the Pittsburgh Sleep Quality Index.Results:Statistically significant differences were observed among anxiety,depression,and sleeping problems between the two groups in the post-test(P<0.05).A significant decrease in anxiety and depression and an improvement in sleep were observed between pre-and post-interventions(P<0.05)in the experimental group.Conclusions:MBPC significantly improved sleep quality and mood of the experimental group.It is an effective complementary therapy for leukemia treatment that is inexpensive,noninvasive,and associated with relaxation and pain reduction.展开更多
The diagnosis of disease and prescription of therapy are mainly realized through the control of physiological functions in humans during wakefulness. However, little attention is paid to evaluate the functional state ...The diagnosis of disease and prescription of therapy are mainly realized through the control of physiological functions in humans during wakefulness. However, little attention is paid to evaluate the functional state of a patient in sleep. The efficiency of prescribed medicines is also determined in wakefulness. The effects of these drugs during sleep are usually out-of-sight of a physician. Human psychoemotional state during wakefulness is closely related to sleep. Various serious disturbances in physiological functions appear during the night sleep. They include cardiovascular disorders （hypertensive crisis, myocardial infarction, arrhythmias, stroke, etc.）, which may cause sudden death. A large body of evidence shows that stress is followed by sleep disorders. They serve as a factor, which contributes to the development of stress. It should be noted that sleep is the major anti-stress factor. The vicious circle is formed, which can be revealed by a complex control of human physiological functions during wakefulness and sleep. We developed a new methodology and constructed an information-and-equipment device for monitoring of vital physiological functions of humans during sleep in a real everyday life. This approach holds much promise for the diagnosis of disease and evaluation of therapeutic efficacy.展开更多
Gestational exposure to PM_(2.5) is associated with adverse postnatal outcomes.PM_(2.5) can enter alveoli by using intratracheal instillation,even penetrate through lung cells into the blood circulation.Subsequently,t...Gestational exposure to PM_(2.5) is associated with adverse postnatal outcomes.PM_(2.5) can enter alveoli by using intratracheal instillation,even penetrate through lung cells into the blood circulation.Subsequently,they are transferred across the placenta and fetal blood brain barrier,causing the adverse birth outcomes of offspring.This study demonstrated that the gestational exposure resulted in cognitive and emotional disorders in female offspring although the offspring were not exposed to PM_(2.5).Placental metabolic pathways modulated fetal brain development and played a pivotal role for maternal-placentalfetal interactions in the fetal programming of adult behavioral and mental disorders.Samples of fetus,offspring hippocampus and placenta from the mice exposed to PM_(2.5) were investigated using a comprehensive approach including mass spectrometry-based lipidomics and three-dimensional imaging.The exposure induced the neuro-degeneration in hippocampus,impairment of placental cytoarchitecture,and reprogramming of lipidome,which might affect the modulation of maternal-fetal cross-talk and result in the behavior disorders of offspring.The variation of spatial distribution of lipids was profoundly affected in dorsal pallium and hippocampal formation regions of fetal brain,offspring hippocampus,as well as labyrinth and junctional zones of placenta.The abundance alteration of lipid markers associated with neurodegenerative diseases was validated in transgenic mouse model with Alzheimer’s disease and human cerebrospinal fluid from patients with Parkinson’s disease.The finding could help with the selection of more suitable heterogeneous-related substructures targeting PM_(2.5) exposure and the exploration of PM_(2.5)-induced toxicological effects on neurodegenerative diseases.展开更多
基金This study was supported by the“Basic and Frontier Technology Research Program”of Henan Province(25-132102310492)the new subject research program of the Nursing College of Zhengzhou University(2014HLXK006).
文摘Purpose:The aim of this research was to explore the benefits of mindfulness-based psychological care(MBPC)and assess whether the intervention would be beneficial in reducing insomnia and emotional symptoms of leukemia patients receiving chemotherapy.Methods:A randomized control design study was applied in two hematology departments in a hospital in Zhengzhou.Patients in the experimental group received mindfulness-based psychological care(MBPC),and those in the control group received conventional care.Anxiety,depression,and sleeping problems were measured using the Self-Rating Anxiety Scale,Self-Rating Depression Scale,and the Pittsburgh Sleep Quality Index.Results:Statistically significant differences were observed among anxiety,depression,and sleeping problems between the two groups in the post-test(P<0.05).A significant decrease in anxiety and depression and an improvement in sleep were observed between pre-and post-interventions(P<0.05)in the experimental group.Conclusions:MBPC significantly improved sleep quality and mood of the experimental group.It is an effective complementary therapy for leukemia treatment that is inexpensive,noninvasive,and associated with relaxation and pain reduction.
文摘The diagnosis of disease and prescription of therapy are mainly realized through the control of physiological functions in humans during wakefulness. However, little attention is paid to evaluate the functional state of a patient in sleep. The efficiency of prescribed medicines is also determined in wakefulness. The effects of these drugs during sleep are usually out-of-sight of a physician. Human psychoemotional state during wakefulness is closely related to sleep. Various serious disturbances in physiological functions appear during the night sleep. They include cardiovascular disorders （hypertensive crisis, myocardial infarction, arrhythmias, stroke, etc.）, which may cause sudden death. A large body of evidence shows that stress is followed by sleep disorders. They serve as a factor, which contributes to the development of stress. It should be noted that sleep is the major anti-stress factor. The vicious circle is formed, which can be revealed by a complex control of human physiological functions during wakefulness and sleep. We developed a new methodology and constructed an information-and-equipment device for monitoring of vital physiological functions of humans during sleep in a real everyday life. This approach holds much promise for the diagnosis of disease and evaluation of therapeutic efficacy.
基金supported by the National Natural Science Foundation of China(91843301)the National Key Research Program of China(2017YFC1600505 and 2017YFE0191000)+1 种基金Sanming Project of Medicine in Shenzhen of China(SZSM201811070)General Research Fund from Hong Kong Research Grants Council(12303320)。
文摘Gestational exposure to PM_(2.5) is associated with adverse postnatal outcomes.PM_(2.5) can enter alveoli by using intratracheal instillation,even penetrate through lung cells into the blood circulation.Subsequently,they are transferred across the placenta and fetal blood brain barrier,causing the adverse birth outcomes of offspring.This study demonstrated that the gestational exposure resulted in cognitive and emotional disorders in female offspring although the offspring were not exposed to PM_(2.5).Placental metabolic pathways modulated fetal brain development and played a pivotal role for maternal-placentalfetal interactions in the fetal programming of adult behavioral and mental disorders.Samples of fetus,offspring hippocampus and placenta from the mice exposed to PM_(2.5) were investigated using a comprehensive approach including mass spectrometry-based lipidomics and three-dimensional imaging.The exposure induced the neuro-degeneration in hippocampus,impairment of placental cytoarchitecture,and reprogramming of lipidome,which might affect the modulation of maternal-fetal cross-talk and result in the behavior disorders of offspring.The variation of spatial distribution of lipids was profoundly affected in dorsal pallium and hippocampal formation regions of fetal brain,offspring hippocampus,as well as labyrinth and junctional zones of placenta.The abundance alteration of lipid markers associated with neurodegenerative diseases was validated in transgenic mouse model with Alzheimer’s disease and human cerebrospinal fluid from patients with Parkinson’s disease.The finding could help with the selection of more suitable heterogeneous-related substructures targeting PM_(2.5) exposure and the exploration of PM_(2.5)-induced toxicological effects on neurodegenerative diseases.
