The attitude adjustment of rope system faces the challenging due to the difficulty in obtaining accurate three-dimensional(3D)mathematical model and solving by traditional methods.A set of adjustment systems is design...The attitude adjustment of rope system faces the challenging due to the difficulty in obtaining accurate three-dimensional(3D)mathematical model and solving by traditional methods.A set of adjustment systems is designed and used to investigate the automatic control for level or preset attitude adjustment of unknown weights and eccentric loads.The system principle and characteristics are analyzed.The 3D model is decomposed into two two-dimensional(2D)subsystems,and an adaptive fuzzy controller based on BP neural network and least squares(LSE)is designed.The simulation experiment uses MATLAB to train the level-adjustment data for testing algorithm,and a small load is used to verify the effectiveness of the system.The experimental results show that precise attitude adjustment can be achieved within the system load range,and the response speed is fast.This adjustment method provides a fast and effective method for precise adjustment of the load attitude.展开更多
For rigid-flexible coupling multi-body with variable topology,such as the system of internally carried air-launched or heavy cargo airdrop,in order to construct a dynamic model with unified form,avoid redundancy in th...For rigid-flexible coupling multi-body with variable topology,such as the system of internally carried air-launched or heavy cargo airdrop,in order to construct a dynamic model with unified form,avoid redundancy in the modeling process and make the solution independent,a method based on the equivalent rigidization model was proposed.It divides a system into independent subsystems by cutting off the joints,of which types are changed with the operation process of the system.And models of different subsystems can be constructed via selecting suitable modeling methods.Subsystem models with flexible bodies are on the basis of the equivalent rigidization model which replaces the flexible bodies with the virtual rigid bodies.And the solution for sanction,which is based on the constraints force algorithm(CFA)and vector mechanics,can be independent on the state equations.The internally carried air-launched system was taken as an example for verifying validity and feasibility of the method and theory.The dynamic model of aircraft-rocket-parachute system in the entire phase was constructed.Comparing the modeling method with the others,the modeling process was programmed;and form of the model is unified and simple.The model,method and theory can be used to analyze other similar systems such as heavy cargo airdrop system and capsule parachute recovery system.展开更多
Traumatic injury of the central nervous system （CNS） including brain and spinal cord remains a leading cause of morbidity and disability in the world. Delineating the mechanisms underlying the secondary and persiste...Traumatic injury of the central nervous system （CNS） including brain and spinal cord remains a leading cause of morbidity and disability in the world. Delineating the mechanisms underlying the secondary and persistent injury versus the primary and transient injury has been drawing extensive attention for study during the past few decades. The sterile neuroinflammation during the secondary phase of injury has been frequently identified substrate underlying CNS injury, but as of now, no conclusive studies have determined whether this is a beneficial or detrimental role in the context of repair. Recent pioneering studies have demonstrated the key roles for the innate and adaptive immune responses in regulating sterile neuroinflammation and CNS repair. Some promising immunotherapeutic strategies have been recently developed for the treatment of CNS injury. This review updates the recent progress on elucidating the roles of the innate and adaptive immune responses in the context of CNS injury, the development and characterization of potential immunotherapeutics, as well as outstanding questions in this field.展开更多
基金National Natural Science Foundation of China(No.61605177)
文摘The attitude adjustment of rope system faces the challenging due to the difficulty in obtaining accurate three-dimensional(3D)mathematical model and solving by traditional methods.A set of adjustment systems is designed and used to investigate the automatic control for level or preset attitude adjustment of unknown weights and eccentric loads.The system principle and characteristics are analyzed.The 3D model is decomposed into two two-dimensional(2D)subsystems,and an adaptive fuzzy controller based on BP neural network and least squares(LSE)is designed.The simulation experiment uses MATLAB to train the level-adjustment data for testing algorithm,and a small load is used to verify the effectiveness of the system.The experimental results show that precise attitude adjustment can be achieved within the system load range,and the response speed is fast.This adjustment method provides a fast and effective method for precise adjustment of the load attitude.
文摘For rigid-flexible coupling multi-body with variable topology,such as the system of internally carried air-launched or heavy cargo airdrop,in order to construct a dynamic model with unified form,avoid redundancy in the modeling process and make the solution independent,a method based on the equivalent rigidization model was proposed.It divides a system into independent subsystems by cutting off the joints,of which types are changed with the operation process of the system.And models of different subsystems can be constructed via selecting suitable modeling methods.Subsystem models with flexible bodies are on the basis of the equivalent rigidization model which replaces the flexible bodies with the virtual rigid bodies.And the solution for sanction,which is based on the constraints force algorithm(CFA)and vector mechanics,can be independent on the state equations.The internally carried air-launched system was taken as an example for verifying validity and feasibility of the method and theory.The dynamic model of aircraft-rocket-parachute system in the entire phase was constructed.Comparing the modeling method with the others,the modeling process was programmed;and form of the model is unified and simple.The model,method and theory can be used to analyze other similar systems such as heavy cargo airdrop system and capsule parachute recovery system.
文摘Traumatic injury of the central nervous system （CNS） including brain and spinal cord remains a leading cause of morbidity and disability in the world. Delineating the mechanisms underlying the secondary and persistent injury versus the primary and transient injury has been drawing extensive attention for study during the past few decades. The sterile neuroinflammation during the secondary phase of injury has been frequently identified substrate underlying CNS injury, but as of now, no conclusive studies have determined whether this is a beneficial or detrimental role in the context of repair. Recent pioneering studies have demonstrated the key roles for the innate and adaptive immune responses in regulating sterile neuroinflammation and CNS repair. Some promising immunotherapeutic strategies have been recently developed for the treatment of CNS injury. This review updates the recent progress on elucidating the roles of the innate and adaptive immune responses in the context of CNS injury, the development and characterization of potential immunotherapeutics, as well as outstanding questions in this field.
