Objective： To study the timing of Bevacizumab （BVC） in the overall treatment strategy of advanced metastatic colorectal cancer - early use （first-line） or later use. Methods： 41 patients with progressive metasta...Objective： To study the timing of Bevacizumab （BVC） in the overall treatment strategy of advanced metastatic colorectal cancer - early use （first-line） or later use. Methods： 41 patients with progressive metastatic colorectal carcinoma were included. Patients were randomized to receive chemotherapy with or without BVC. Primary end point was objective response. Secondary end points were median survival, time to tumor progression, and toxicity. Results： Partial response with second-line BVC group constituted 25% and 18.8% in patients with first-line chemotherapy and BVC-based regimen respectively, compared to 11.8% and 5.9% with second-line chemotherapy. Median time to progression was 3.1 vs. 2.3 months for cases with first-line chemotherapy and BVC-based regimens respectively. Median survival was 8.2 vs. 4 months in both groups respectively （P = 0.019）. Conclusion： Second-line chemotherapy combined BVC had higher disease control rate （partial response and stable disease）, median time to progression and median survival in BVC-naive patients compared to patients with first-line BVC-based therapy. BVC should be maintained in the second- and third-line settings, as cases with BVC discontinuation had significantly lower median time to disease progression and median survival. Selection of patients for use of BVC was recommended with taking into consideration the cost-benefit value and that the discontinuation of BVC would increase tumor progression.展开更多
This paper deals with transformation procedures for observed GPS data from the world geodetic system WGS84 into the national geodetic grid datum SUTCN （system of united trigonometric cadaster network） and Baa（the B...This paper deals with transformation procedures for observed GPS data from the world geodetic system WGS84 into the national geodetic grid datum SUTCN （system of united trigonometric cadaster network） and Baa（the Baltic Sea after adjustment）.Transformation from WGS84 into SUTCN is performed most frequently by means of the 7element Helmert transformation with three identical points.Geodetic network was adjusted by two ways.展开更多
Systematic approach to the maintenance of rural road network is a very important issue from the viewpoint of public costs. Most countries developed custom PMS （pavement management systems） based on deterministic or ...Systematic approach to the maintenance of rural road network is a very important issue from the viewpoint of public costs. Most countries developed custom PMS （pavement management systems） based on deterministic or probabilistic approach. The main goal is to ensure safety and continuity of road traffic on road network with low intensity and lower technical requirements. Article presents PMS used for Slovakia rural road network based on road construction diagnostics, traffic volume, climate factors and evaluation of maintenance works economics effectives by using of software tools like HDM-4 developed by World Bank. Local road administrators of rural road networks often lack the software equipment, most PMS, however effective, are often cumbersome, demanding in regard to energy, know-how and software equipment. The majority of local road administrators of rural road networks thus resort to non-effective reactive maintenance strategies. This article describes an easy to use method, based on predetermined maintenance repair and rehabilitation standards. A simple method, based on road user cost, is introduced that administrator can use to prepare a list of road section eligible for repair according to their repair priority.展开更多
文摘Objective： To study the timing of Bevacizumab （BVC） in the overall treatment strategy of advanced metastatic colorectal cancer - early use （first-line） or later use. Methods： 41 patients with progressive metastatic colorectal carcinoma were included. Patients were randomized to receive chemotherapy with or without BVC. Primary end point was objective response. Secondary end points were median survival, time to tumor progression, and toxicity. Results： Partial response with second-line BVC group constituted 25% and 18.8% in patients with first-line chemotherapy and BVC-based regimen respectively, compared to 11.8% and 5.9% with second-line chemotherapy. Median time to progression was 3.1 vs. 2.3 months for cases with first-line chemotherapy and BVC-based regimens respectively. Median survival was 8.2 vs. 4 months in both groups respectively （P = 0.019）. Conclusion： Second-line chemotherapy combined BVC had higher disease control rate （partial response and stable disease）, median time to progression and median survival in BVC-naive patients compared to patients with first-line BVC-based therapy. BVC should be maintained in the second- and third-line settings, as cases with BVC discontinuation had significantly lower median time to disease progression and median survival. Selection of patients for use of BVC was recommended with taking into consideration the cost-benefit value and that the discontinuation of BVC would increase tumor progression.
文摘This paper deals with transformation procedures for observed GPS data from the world geodetic system WGS84 into the national geodetic grid datum SUTCN （system of united trigonometric cadaster network） and Baa（the Baltic Sea after adjustment）.Transformation from WGS84 into SUTCN is performed most frequently by means of the 7element Helmert transformation with three identical points.Geodetic network was adjusted by two ways.
文摘Systematic approach to the maintenance of rural road network is a very important issue from the viewpoint of public costs. Most countries developed custom PMS （pavement management systems） based on deterministic or probabilistic approach. The main goal is to ensure safety and continuity of road traffic on road network with low intensity and lower technical requirements. Article presents PMS used for Slovakia rural road network based on road construction diagnostics, traffic volume, climate factors and evaluation of maintenance works economics effectives by using of software tools like HDM-4 developed by World Bank. Local road administrators of rural road networks often lack the software equipment, most PMS, however effective, are often cumbersome, demanding in regard to energy, know-how and software equipment. The majority of local road administrators of rural road networks thus resort to non-effective reactive maintenance strategies. This article describes an easy to use method, based on predetermined maintenance repair and rehabilitation standards. A simple method, based on road user cost, is introduced that administrator can use to prepare a list of road section eligible for repair according to their repair priority.
