Purpose:To report the peripheral abnormalities seen only with indocyanine green angiography in patients with vitelliform macular dystrophy(Best disease,caused by a mutation in the bestrophin gene).Design:Observational...Purpose:To report the peripheral abnormalities seen only with indocyanine green angiography in patients with vitelliform macular dystrophy(Best disease,caused by a mutation in the bestrophin gene).Design:Observational case report series.Methods:Eight eyes of four patients,two with only a central macular lesion and two with multifocal lesions,were studied.Results of indocyanine green angiography were compared with findings from ophthalmoscopy and fluorescein angiography.Results:Throughout the fundus periphery,indocyanine green angiography demonstrated a number of hyperfluorescent spots in all eight eyes.The spots were observed in the midperiphery and the periphery in areas with no abnormality visible by ophthalmoscopy or fluorescein angiography.Conclusions:Although Best disease generally causes lesions visible in the posterior pole,the extensive distribution of the hyperfluorescent spots is consistent with the wide-ranging abnormalities of the retinal pigment epithelium,Bruch membrane,and the choroid as seen histopathologically.展开更多
目的探讨脉络膜血管瘤的眼底荧光血管造影(fundus flurorescence angiography,FFA)及吲哚菁绿血管造影(indocyanine green angiography,ICGA)的影像特征。方法回顾性分析9例(9只眼)脉络膜血管瘤患者的临床资料,对比分析其FFA及ICGA检查...目的探讨脉络膜血管瘤的眼底荧光血管造影(fundus flurorescence angiography,FFA)及吲哚菁绿血管造影(indocyanine green angiography,ICGA)的影像特征。方法回顾性分析9例(9只眼)脉络膜血管瘤患者的临床资料,对比分析其FFA及ICGA检查影像特征。结果FFA早期均出现形似脉络膜血管的高荧光,动静脉期荧光渗漏、逐渐增强并融合,晚期呈斑驳状强荧光。ICGA早期清晰可见不规则的脉络膜血管,中期瘤体呈强荧光,可以看出脉络膜血管瘤的边界,晚期病灶内染料排空,呈现低荧光。结论脉络膜血管瘤的FFA、ICGA图像各具特征,两者联合有助于脉络膜血管瘤的诊断。展开更多
文摘Purpose:To report the peripheral abnormalities seen only with indocyanine green angiography in patients with vitelliform macular dystrophy(Best disease,caused by a mutation in the bestrophin gene).Design:Observational case report series.Methods:Eight eyes of four patients,two with only a central macular lesion and two with multifocal lesions,were studied.Results of indocyanine green angiography were compared with findings from ophthalmoscopy and fluorescein angiography.Results:Throughout the fundus periphery,indocyanine green angiography demonstrated a number of hyperfluorescent spots in all eight eyes.The spots were observed in the midperiphery and the periphery in areas with no abnormality visible by ophthalmoscopy or fluorescein angiography.Conclusions:Although Best disease generally causes lesions visible in the posterior pole,the extensive distribution of the hyperfluorescent spots is consistent with the wide-ranging abnormalities of the retinal pigment epithelium,Bruch membrane,and the choroid as seen histopathologically.
文摘目的探讨脉络膜血管瘤的眼底荧光血管造影(fundus flurorescence angiography,FFA)及吲哚菁绿血管造影(indocyanine green angiography,ICGA)的影像特征。方法回顾性分析9例(9只眼)脉络膜血管瘤患者的临床资料,对比分析其FFA及ICGA检查影像特征。结果FFA早期均出现形似脉络膜血管的高荧光,动静脉期荧光渗漏、逐渐增强并融合,晚期呈斑驳状强荧光。ICGA早期清晰可见不规则的脉络膜血管,中期瘤体呈强荧光,可以看出脉络膜血管瘤的边界,晚期病灶内染料排空,呈现低荧光。结论脉络膜血管瘤的FFA、ICGA图像各具特征,两者联合有助于脉络膜血管瘤的诊断。