2.5%溴氰菊酯缓释型微乳剂防制卫生害虫的研究

目的 :以水替代有机溶剂减少环境污染 ,以高分子材料作为缓释剂控制药物释放速度。方法 :参照农药登记室内药效实验有关方法等。结果 :该剂对蚊、蝇击倒迅速 ,杀灭力强 ,与 2 .5 %敌杀死EC相当 ;作为滞留喷洒其持效性长 ,与 2 .5 %凯素灵相近。毒性低、热贮稳定性好 ,并在一定温度范围内保持物理稳定性。结论

“冰点24”缓释长效退热注射乳剂的临床药效学试验报告

用二级新西兰试验兔和猪对“冰点24”缓释长效退热注射乳剂的临床药效试验表明,该品对仔猪副伤寒活疫苗+副伤寒甲、乙型菌液致热的新西兰兔(体温上升41℃以上)按0.2ml/kg体重肌内注射,用药1次,0.5小时后开始退热,退热至常温(39.6℃)的效果维持在25.1h;对人工感染兔巴氏杆菌(pasteurellosiscuniculum)发病兔按0.2ml/kg体重肌内注射,每日1次,连用3天,保护率95%;对自然发热病猪按0.2ml/kg体重注射,每日1次,连用3天的退热有效率100%,治疗有效率95.7%,因而指示该药可作为速效+长效退热注射剂提供临床应用。用猪(20kg±1kg体重)3只进行药代动力学分析:其有效成分的Cmax(峰值浓度)=15.28μg/ml,tmax(达峰时间)=1.22h,t1/2(半衰期)=8.03h,AUC(药时曲线下面积)=196.37μg/(ml·h),也说明其在猪体内的长效作用特征。

口服液体控释给药系统研究进展

口服液体控释给药系统是一种新型药物传递系统，因其存在物理不稳定性，所以能上市的品种较少。本文提出了解决物理稳定性的技术，如：选择具有水难溶性的药物；用药物饱和水溶液作为混悬介质；用非水溶液作为混悬介质；制成临用前重新配制的干混悬剂；优化混悬介质处方；采用定位（ｉｎｓｉｔｕ）凝胶机制；缓释乳剂；用离子交换树脂作为药物载体等。并着重介绍了口服药物脂液体控释系统的设计原理。

Development of Prolonged Release Microspheres of Metformin Hydrochloride Using Ion Exchange Resins

Aim To prepare the prolonged-released microspheres of mefformin hydrochloride. Methods Ion-exchange resin-drug mefformin hydrochloride complexes were prepared as core materials, and followed by coating using ethylcellulose （EC） by the emulsion solvent diffusion technique. The release rate of mefformin from the microcapsules was highly dependent on the encapsulating formulation, thus being used as an index for formulation screening. Orthogonal experiments were performed to optimize the coating formulation. Results The final chosen formulation for coating of mefformin microcapsules were as follows： （ 1 ） the ratio of EC （20cps） to EC （45cps） was 50：50; （2） the ratio of plasticizer to coating materials was 20% ;and （3） the ratio of resin-mefformin complexes to coating materials was 5 ： 1. Conclusion The prolonged release microspheres of mefformin hydrochloride were successfully prepared.