甘肃省马驽巴贝斯虫病综合防治研究

在查明了 30余年来流行于甘肃省陇东南地区的一种马病病原为驽巴贝斯虫 ,传媒为森林革蜱和草原革蜱的基础上 ,开展了综合防治研究工作。通过抗血液原虫药物的治疗试验 ,证明咪唑苯脲、贝尼尔、黄色素、焦虫净对驽巴贝斯虫病的治愈率分别为10 0 %、84.6 2 %、81.82 %、73.33%。对贝尼尔用药途径改肌注为静脉滴注后治愈率由 84.6 2 %提高到 90 .6 3% ,且副反应大幅度降低。药物预防试验中证明咪唑苯脲、焦虫净、贝尼尔预防效果均达 98%以上 ,有效保护期分别为 5 9、2 4、12天。应用敌杀死灭蜱预防 ,效果达 10 0 % ,有效保护期为 2 3天。成功地研制出了咪唑苯脲缓释剂 ,其预防效果达 10 0 % ,有效保护期为 113天。研究制定了“三双”综合防治措施 ,在流行区 15个县 (区 )实施 3年 ,共治愈马类家畜 119175匹 ,预防马类家畜90 5 2 0 0匹。流行区发病率由 13.85 %降到 0 .0 9% ,死亡率由 5 .6 5 %降到 0 .0 4%。获得经济效益 890 8.98万元。

The effect of fluorouracil controlled release formulation in the treatment of 32 cases with advanced colorectal cancer by local implant

Objective: The aim of our study was to probe into the effect of fluorouracil controlled release formulation in the local implant treatment of patients with advanced colorectal cancer. Methods: Sixty-four cases of patients advanced colorectal cancer from August 2004 to February 2008 were selected for radical surgery, including 32 cases injected with intraoperative fluorouracil controlled release formulation in local implantation for 600 mg (the treatment group). Patients in another 32 cases received abdominal washing surgery by distilled water (the control group). All patients were followed up for 2 years and observed in aspects of the toxicity, 2-year survival rate, local recurrence rate and distant metastasis rate. Results: The 2-year survival rate and local recurrence rate in the treatment group was better than those in the control group (P < 0.05); as for toxicity and distant metastasis rate, no significant difference was observed. Conclusion: The effect of fluorouracil controlled release formulation in local implantation treatment was significant and the patient tolerance was satisfactory. Thus, it is an effective approach in the treatment of advanced colorectal cancer.