To investigate the pharmacokinetic characteristics of moclobemide sustainedrelease tablets after multiple oral dose administration in healthy Chinese volunteers. MethodsMoclobemide sustained release tablets were given...To investigate the pharmacokinetic characteristics of moclobemide sustainedrelease tablets after multiple oral dose administration in healthy Chinese volunteers. MethodsMoclobemide sustained release tablets were given as a multiple oral dose regimen of 300 mg oncedaily for five consecutive days to 12 healthy volunteers. The concentrations of moclobemide inplasma were determined by reversed-phase high performance liquid chromatography. The partialpharmacokinetic parameters were calculated using 3p97 pharmacokinetic program. Results Theconcentration-time profile fitted an one-compartment model best. The steady-state pharmacokineticparameters of moclobemide sustained release tablets after multiple oral doses were as follows:C_(max) was (1 950 +- 156) μg· L^(-1), T_(max) was (6.00 +-1.55) h, T_(1/2(kel)) was (3.14 +-0.12)h, AUC_(ss 0-24) was (22 836 +- 1 842) μg·h· L^(-1), MRT was (7.68+-0.36) h, CL/F_((s)) was(20.2+-2.1) L·h^(-1), and V/F_((c)) was (91.4+-9.4) L, respectively. No marked adverse events werenoted during this study. Conclusion The formulation has a sustained-release effect and goodtolerance in the healthy volunteers, which provides useful information for clinical practice.展开更多
[Objective] The aim was to get a high yield and simplify fertilization of summer corn in moisture soils in the east of Henan province. [Method] Effects of slow-release fertilizers special for summer corn on its yield,...[Objective] The aim was to get a high yield and simplify fertilization of summer corn in moisture soils in the east of Henan province. [Method] Effects of slow-release fertilizers special for summer corn on its yield, economic benefits and resistance. [Result] By the slow-release fertilizers containing 45% slow-release nitrogen, thousand-kernel weight and the number of ear went up by 28 g and 16 kernels, respectively. Slow-release fertilizers advanced nutrient uptake by summer corns and kept soil nitrogen balanced. In comparison to local fertilization approach, corn yield grew by 13.5% and net profit went up by 1 920 yuan/hm^2 by same-term application technique of seed ＆ slow-release fertilizer in comparison to local methods. In comparison to normal fertilizers containing the same-quantity nutrients, corn yield grew by 10.3% and net profit by 1 215 yuan/hm^2. [Conclusion] The research provides references for slow-release fertilizer promotion in production of corn in Zhoukou and innovation and integration between agricultural machines and techniques.展开更多
文摘To investigate the pharmacokinetic characteristics of moclobemide sustainedrelease tablets after multiple oral dose administration in healthy Chinese volunteers. MethodsMoclobemide sustained release tablets were given as a multiple oral dose regimen of 300 mg oncedaily for five consecutive days to 12 healthy volunteers. The concentrations of moclobemide inplasma were determined by reversed-phase high performance liquid chromatography. The partialpharmacokinetic parameters were calculated using 3p97 pharmacokinetic program. Results Theconcentration-time profile fitted an one-compartment model best. The steady-state pharmacokineticparameters of moclobemide sustained release tablets after multiple oral doses were as follows:C_(max) was (1 950 +- 156) μg· L^(-1), T_(max) was (6.00 +-1.55) h, T_(1/2(kel)) was (3.14 +-0.12)h, AUC_(ss 0-24) was (22 836 +- 1 842) μg·h· L^(-1), MRT was (7.68+-0.36) h, CL/F_((s)) was(20.2+-2.1) L·h^(-1), and V/F_((c)) was (91.4+-9.4) L, respectively. No marked adverse events werenoted during this study. Conclusion The formulation has a sustained-release effect and goodtolerance in the healthy volunteers, which provides useful information for clinical practice.
基金Supported by National Project of Soil Testing and Formulated FertilizationKingenta Project~~
文摘[Objective] The aim was to get a high yield and simplify fertilization of summer corn in moisture soils in the east of Henan province. [Method] Effects of slow-release fertilizers special for summer corn on its yield, economic benefits and resistance. [Result] By the slow-release fertilizers containing 45% slow-release nitrogen, thousand-kernel weight and the number of ear went up by 28 g and 16 kernels, respectively. Slow-release fertilizers advanced nutrient uptake by summer corns and kept soil nitrogen balanced. In comparison to local fertilization approach, corn yield grew by 13.5% and net profit went up by 1 920 yuan/hm^2 by same-term application technique of seed ＆ slow-release fertilizer in comparison to local methods. In comparison to normal fertilizers containing the same-quantity nutrients, corn yield grew by 10.3% and net profit by 1 215 yuan/hm^2. [Conclusion] The research provides references for slow-release fertilizer promotion in production of corn in Zhoukou and innovation and integration between agricultural machines and techniques.
