COVID-19是由SARS-CoV-2感染引起的一种呼吸道疾病,具有较强的传染力,严重威胁人类健康,接种疫苗是预防SARS-CoV-2感染最有效的手段。世界卫生组织(World Health Organization,WHO)要求使用国际物品编码组织(Global Standard 1,GS1)标...COVID-19是由SARS-CoV-2感染引起的一种呼吸道疾病,具有较强的传染力,严重威胁人类健康,接种疫苗是预防SARS-CoV-2感染最有效的手段。世界卫生组织(World Health Organization,WHO)要求使用国际物品编码组织(Global Standard 1,GS1)标准实现对新型冠状病毒疫苗(简称新冠疫苗)和治疗制剂的跟踪与追溯。追溯标识系统是追溯系统的基础和核心,是实施追溯的前提,贯穿于整个产品追溯过程中。通过对出口疫苗产品各级包装及物流单元进行全球唯一性编码、建立疫苗追溯码和物流单元追溯码标识,帮助出口疫苗生产企业建立追溯制度,实现产品生产、流通、使用等环节信息的追溯,可强化出口疫苗产品质量安全监管、风险监测预警和有效处置、问题产品召回及原因分析,增强国际市场对中国疫苗安全的信任与认可。本文对出口疫苗产品建立追溯制度的重要性、GS1系统在国内外医疗领域的应用、出口疫苗产品追溯标识编码、条码表示及质量要求作一综述,以期为我国出口疫苗产品建立追溯标识制度,满足国际标准法规要求提供参考。展开更多
Industry experts are increasingly focusing on team productivity on team productivity as the key to success,the base of the team effort is the four-fold structure of software in terms of logical organisation,physical o...Industry experts are increasingly focusing on team productivity on team productivity as the key to success,the base of the team effort is the four-fold structure of software in terms of logical organisation,physical organisation,managerial organisation,and dynamical structure.We describe the ideas put into action within the CMS software for organising software into sub-systems and packages,and to establish configuration management in a multiproject environment.We use a structure that allows to maximise the independence of soft ware development in individual areas,and at the same time emphasises the overwhelming importance of the interdependencies between the packages and components in the system.We comment on release procedures,and describe the inter-relationship between release,development,integration,and testing.展开更多
Based on the driver surveillance video data and controller area network(CAN)data,the methods of studying commercial vehicles’driving behavior is relatively advanced.However,these methods have difficulty in covering p...Based on the driver surveillance video data and controller area network(CAN)data,the methods of studying commercial vehicles’driving behavior is relatively advanced.However,these methods have difficulty in covering private vehicles.Naturalistic driving studies have disadvantages of small sample size and high cost,one new driving behavior evaluation method using massive vehicle trajectory data is put forward.An automatic encoding machine is used to reduce the noise of raw data,and then driving dynamics and self-organizing mapping(SOM)classification are used to give thresholds or the judgement method of overspeed,rapid speed change,rapid turning and rapid lane changing.The proportion of different driving behaviors and typical dangerous driving behaviors is calculated,then the temporal and spatial distribution of drivers’driving behavior and the driving behavior characteristics on typical roads are analyzed.Driving behaviors on accident-prone road sections and normal road sections are compared.Results show that in Shenzhen,frequent lane changing and overspeed are the most common unsafe driving behaviors;16.1%drivers have relatively aggressive driving behavior;the proportion of dangerous driving behavior is higher outside the original economic special zone;dangerous driving behavior is highly correlated with traffic accident frequency.展开更多
Tissue engineering is a relatively new but rapidly developing field in the medical sciences. Noncoding RNAs(ncRNAs) are functional RNA molecules without a protein-coding function; they can regulate cellular behavior a...Tissue engineering is a relatively new but rapidly developing field in the medical sciences. Noncoding RNAs(ncRNAs) are functional RNA molecules without a protein-coding function; they can regulate cellular behavior and change the biological milieu of the tissue. The application of ncRNAs in tissue engineering is starting to attract increasing attention as a means of resolving a large number of unmet healthcare needs, although ncRNA-based approaches have not yet entered clinical practice. In-depth research on the regulation and delivery of ncRNAs may improve their application in tissue engineering.The aim of this review is: to outline essential ncRNAs that are related to tissue engineering for the repair and regeneration of nerve, skin, liver, vascular system, and muscle tissue; to discuss their regulation and delivery; and to anticipate their potential therapeutic applications.展开更多
MicroRNAs (miRNAs) belong to a class of noncoding, regulatory RNAs that are involved in oncogenesis and show remarkable tissue specificity.miRNAs are approximately 22 nt non-coding RNAs, which regulate gene expression...MicroRNAs (miRNAs) belong to a class of noncoding, regulatory RNAs that are involved in oncogenesis and show remarkable tissue specificity.miRNAs are approximately 22 nt non-coding RNAs, which regulate gene expression in a sequence-specific manner via translational inhibition or messenger RNA (mRNA) degradation, thus affecting various cellular processes.Since the discovery of their fundamental mechanisms of action, the field of miRNAs has opened a new era in the understanding of small noncoding RNAs.Recent evidence has shown that miRNA controls cell growth, apoptosis, and differentiation.Cancer is a complex genetic disease caused by abnormalities in gene structure and expression, moreover, miRNA expression correlates with cancers and could have a crucial function in tumor progression.Bioinformatic data indicate that each miRNA can control hundreds of target genes, but identification of the accurate miRNA targets will be crucial to exploit the emerging knowledge of miRNA contribution to cancer process.展开更多
文摘COVID-19是由SARS-CoV-2感染引起的一种呼吸道疾病,具有较强的传染力,严重威胁人类健康,接种疫苗是预防SARS-CoV-2感染最有效的手段。世界卫生组织(World Health Organization,WHO)要求使用国际物品编码组织(Global Standard 1,GS1)标准实现对新型冠状病毒疫苗(简称新冠疫苗)和治疗制剂的跟踪与追溯。追溯标识系统是追溯系统的基础和核心,是实施追溯的前提,贯穿于整个产品追溯过程中。通过对出口疫苗产品各级包装及物流单元进行全球唯一性编码、建立疫苗追溯码和物流单元追溯码标识,帮助出口疫苗生产企业建立追溯制度,实现产品生产、流通、使用等环节信息的追溯,可强化出口疫苗产品质量安全监管、风险监测预警和有效处置、问题产品召回及原因分析,增强国际市场对中国疫苗安全的信任与认可。本文对出口疫苗产品建立追溯制度的重要性、GS1系统在国内外医疗领域的应用、出口疫苗产品追溯标识编码、条码表示及质量要求作一综述,以期为我国出口疫苗产品建立追溯标识制度,满足国际标准法规要求提供参考。
文摘Industry experts are increasingly focusing on team productivity on team productivity as the key to success,the base of the team effort is the four-fold structure of software in terms of logical organisation,physical organisation,managerial organisation,and dynamical structure.We describe the ideas put into action within the CMS software for organising software into sub-systems and packages,and to establish configuration management in a multiproject environment.We use a structure that allows to maximise the independence of soft ware development in individual areas,and at the same time emphasises the overwhelming importance of the interdependencies between the packages and components in the system.We comment on release procedures,and describe the inter-relationship between release,development,integration,and testing.
基金The National Natural Science Foundation of China(No.71641005)the National Key Research and Development Program of China(No.2018YFB1601105)
文摘Based on the driver surveillance video data and controller area network(CAN)data,the methods of studying commercial vehicles’driving behavior is relatively advanced.However,these methods have difficulty in covering private vehicles.Naturalistic driving studies have disadvantages of small sample size and high cost,one new driving behavior evaluation method using massive vehicle trajectory data is put forward.An automatic encoding machine is used to reduce the noise of raw data,and then driving dynamics and self-organizing mapping(SOM)classification are used to give thresholds or the judgement method of overspeed,rapid speed change,rapid turning and rapid lane changing.The proportion of different driving behaviors and typical dangerous driving behaviors is calculated,then the temporal and spatial distribution of drivers’driving behavior and the driving behavior characteristics on typical roads are analyzed.Driving behaviors on accident-prone road sections and normal road sections are compared.Results show that in Shenzhen,frequent lane changing and overspeed are the most common unsafe driving behaviors;16.1%drivers have relatively aggressive driving behavior;the proportion of dangerous driving behavior is higher outside the original economic special zone;dangerous driving behavior is highly correlated with traffic accident frequency.
基金This work was supported by the National Basic Research Program of China （973 Program, 2014CB542202）, the National HiTech Research and Development Program of China （863 Program, 2012AA020502）, the National Natural Science Foundation of China （81130080 and 31300879）, and the Key University Science Research Project of Jiangsu Province （16KJA310005）. It was also a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions （PAPD）.
文摘Tissue engineering is a relatively new but rapidly developing field in the medical sciences. Noncoding RNAs(ncRNAs) are functional RNA molecules without a protein-coding function; they can regulate cellular behavior and change the biological milieu of the tissue. The application of ncRNAs in tissue engineering is starting to attract increasing attention as a means of resolving a large number of unmet healthcare needs, although ncRNA-based approaches have not yet entered clinical practice. In-depth research on the regulation and delivery of ncRNAs may improve their application in tissue engineering.The aim of this review is: to outline essential ncRNAs that are related to tissue engineering for the repair and regeneration of nerve, skin, liver, vascular system, and muscle tissue; to discuss their regulation and delivery; and to anticipate their potential therapeutic applications.
文摘MicroRNAs (miRNAs) belong to a class of noncoding, regulatory RNAs that are involved in oncogenesis and show remarkable tissue specificity.miRNAs are approximately 22 nt non-coding RNAs, which regulate gene expression in a sequence-specific manner via translational inhibition or messenger RNA (mRNA) degradation, thus affecting various cellular processes.Since the discovery of their fundamental mechanisms of action, the field of miRNAs has opened a new era in the understanding of small noncoding RNAs.Recent evidence has shown that miRNA controls cell growth, apoptosis, and differentiation.Cancer is a complex genetic disease caused by abnormalities in gene structure and expression, moreover, miRNA expression correlates with cancers and could have a crucial function in tumor progression.Bioinformatic data indicate that each miRNA can control hundreds of target genes, but identification of the accurate miRNA targets will be crucial to exploit the emerging knowledge of miRNA contribution to cancer process.
