Uging diet control method to feed the weaning male Wistar rats with selenium and iodine deficiency Keshan endemic area food for 8 weeks to set up animal model. Singal channel recortling in cell attached model was used...Uging diet control method to feed the weaning male Wistar rats with selenium and iodine deficiency Keshan endemic area food for 8 weeks to set up animal model. Singal channel recortling in cell attached model was used to measure cardiac cell membrane potassium channel conductances. which coincide with the cardiac cell membrane potassium channel conductances in normal Wistar rats.The potassium channel conductance on selenlum and lodine cleficiency rat cardiac cell membrane is showing current-voltage increasing lineally in the range of clamping volatge 0±30 mV with channel conductance of 43.4 pS. The channel current does not increase depending on the clamping voltage that is showing the rectifying characteristic and the channel current amplitude can be augmented by added KIOa 5 mmol/L in bath solution. A kind of inward rectiyfing potassium channel activity was recorded, but this channel activity disappeared affer lasting 6～ 10 minutes only. Then an inward rectifying potassium channel with the conductance of 11. 2 PS was activated by KIOa 5 mmol/L, introduced to bath solution. Both conductances are less than that of normal Wistar rats.展开更多
文摘Uging diet control method to feed the weaning male Wistar rats with selenium and iodine deficiency Keshan endemic area food for 8 weeks to set up animal model. Singal channel recortling in cell attached model was used to measure cardiac cell membrane potassium channel conductances. which coincide with the cardiac cell membrane potassium channel conductances in normal Wistar rats.The potassium channel conductance on selenlum and lodine cleficiency rat cardiac cell membrane is showing current-voltage increasing lineally in the range of clamping volatge 0±30 mV with channel conductance of 43.4 pS. The channel current does not increase depending on the clamping voltage that is showing the rectifying characteristic and the channel current amplitude can be augmented by added KIOa 5 mmol/L in bath solution. A kind of inward rectiyfing potassium channel activity was recorded, but this channel activity disappeared affer lasting 6～ 10 minutes only. Then an inward rectifying potassium channel with the conductance of 11. 2 PS was activated by KIOa 5 mmol/L, introduced to bath solution. Both conductances are less than that of normal Wistar rats.
