AIM To investigate the prevalence and related risk factors of birth defects in Shanghai. METHODS This report describes a population-based study of all births at the Obstetrics and Gynecology Hospital of Fudan Universi...AIM To investigate the prevalence and related risk factors of birth defects in Shanghai. METHODS This report describes a population-based study of all births at the Obstetrics and Gynecology Hospital of Fudan University in Shanghai, China from January 2008 to December 2014. A logistic regression analysis was used to identify the parameters that are independently associated with birth defects. RESULTS A total of 82814 births, including 824 cases of birth defects, were recorded. The rate of birth defects was 0.995 per 100 births. In the multivariable regression analysis, neonatal birth defects were likely to be associated with higher gravidity [odds ratio(OR), 1.099, 95%CI: 1.024-1.178], premature birth(OR = 1.905, 95%CI: 1.501-2.418), low birth weight(OR = 3.844, 95%CI: 3.004-4.919), twin births or higher order multiple pregnancies(OR = 1.477, 95%CI: 1.107-1.969), cesarean delivery(OR = 1.184, 95%CI: 1.016-1.380) and registration as part of a migrant population(OR = 1.380, 95%CI: 1.167-1.632). Female infants were less likely to have birth defects than male infants(OR = 0.710, 95%CI: 0.616-0.818). CONCLUSION Higher gravidity, premature birth, lower birth weight,twin births or higher order multiple pregnancies, and registration as part of a migrant population are independent predictors of birth defects.展开更多
This study focuses on the characters of public perceptions on climate and cryosphere change,which are based on a questionnaire survey in the(U|¨)r(u|¨)mqi River Basin.In comparison with scientific observatio...This study focuses on the characters of public perceptions on climate and cryosphere change,which are based on a questionnaire survey in the(U|¨)r(u|¨)mqi River Basin.In comparison with scientific observation results of climate and cryosphere change,this paper analyzes the possible impact of the change on water resources and agriculture production in the area.Perceptions of most respondents on climate and cryosphere changes confirm the main objective facts.For the selection of adaptation measures addressing the shortage of water resource,the results are as follows:most people preferred to choose the measures like "policy change" and "basic facility construction" which are mostly implemented by the government and the policy-making department;some people showed more preference to the measures of avoiding unfavorable natural environment,such as finding job in or migrating to other places.The urgency of personal participation in the adaptation measures is still inadequate.Some adaptation measures should be implemented in line with local conditions and require the organic combination of "resource-development" with "water-saving".展开更多
The levels of somatostatin(SS)in CSF and blood and pancreatic polypeptide(PP)inplasma were measured by radioimmunoassay in 64 patients with acute ischemiccerebrovascular diseases(ICVD),randomly divided into two groups...The levels of somatostatin(SS)in CSF and blood and pancreatic polypeptide(PP)inplasma were measured by radioimmunoassay in 64 patients with acute ischemiccerebrovascular diseases(ICVD),randomly divided into two groups:group 1(n=31,bothelectro-acupuncture and routine treatments given)and group 2(n=33,routine treatment)and 26 non-ICVD patients were used as controls.The points of electro-acupuncture wereQuchi(LI 12),Waiguan(SJ 5)and Huantiao(GB 30)and Zusanli(St 36).After a courseof treatment,the SS levels in plasma and CSF were significantly increased in the patientsof group 1 with good result and their plasma PP level had no significant change.In thepatients with poor result,however,the PP level was significantly decreased.The resultssuggested that electro-acupuncture might play an active role in alleviating the SSmetabolic disturbance in CNS of ICVD patients.展开更多
The research and application on small denture machining equipment are great breakthrough for modern dental restoration technology. In this paper, a small denture machining equipment made of two spindles with four-axis...The research and application on small denture machining equipment are great breakthrough for modern dental restoration technology. In this paper, a small denture machining equipment made of two spindles with four-axis was designed based on machining characteristics and functional analysis. Position accuracy and re-position accuracy were measured by accuracy instrument. In order to test its machining capacity, some typical microstcucture parts, such as straight channel, hemispherical surface, and molars coronal, were selected for high speed milling. It was obtained that the denture machining equipment met the machining requirements with high quality and efficiency, according to the acquisition and analysis of form and position errors, surface roughness, and 3-D profile.展开更多
Objective To evaluate physicians' attitude and knowledge about the management of adult growth hormone deficiency(AGHD) at Peking Union Medical College Hospital and impact factors associated with better decision-ma...Objective To evaluate physicians' attitude and knowledge about the management of adult growth hormone deficiency(AGHD) at Peking Union Medical College Hospital and impact factors associated with better decision-making.Methods A 21-question anonymous survey was distributed and collected at Peking Union Medical College Hospital,a major teaching hospital in Chinese Academy of Medical Sciences.Data of physicians' educational background,clinical training,patient workload per year and continuing medical education in AGHD were collected.Factors associated with appropriate answers were further analyzed by multivariate regression models.Results One hundred and eighteen internal medicine residents,endocrine fellows,attending physicians and visiting physicians responded to the survey.Among them,44.9% thought that AGHD patients should accept recombinant human growth hormone replacement therapy.Moreover,56.8% selected insulin tolerance test and growth hormone-releasing hormone-arginine test for the diagnosis of AGHD.Logistic regression analysis of physician demographic data,educational background,and work experience found no consistent independent factors associated with better decision-making,other than continued medical education,that were associated with treatment choice.Conclusions The physicians' reported management of AGHD in this major academic healthcare center in Beijing was inconsistent with current evidence.High quality continued medical education is required to improve Chinese physician management of AGHD.展开更多
Objective： The aim of the study was to discuss surgical treatment of right colon carcinoma of hepatic flexure invading the duodenum. Methods： The 65 patients with right colon carcinoma of hepatic flexure invading th...Objective： The aim of the study was to discuss surgical treatment of right colon carcinoma of hepatic flexure invading the duodenum. Methods： The 65 patients with right colon carcinoma of hepatic flexure invading the duodenum, treated in our department from 1987 to 2007, were included in this study. Their clinicopathological data were retrospectively reviewed and analyzed. All the cases were divided into three types （local invasion, regional invasion, and cancer with internal fistula） according to duodenal defect, including local invasion （ 2.0 cm）, wide invasion （ 2.0 cm） and the presence of internal fistula. Results： The 25 patients with local invasion underwent en bloc resection of the duodenal wall. Pedicled ileal flap was used to cover the large duodenal defect measuring 2.0–3.0 cm in 5 patients. Dudenojejunostomy was used to reconstruct the large defect measuring more than 5 cm in 3 patients. Conservative resection of right-sided colon was performed in 18 patients with wide invasion. Four patients underwent pancreaticoduodenectomy combined with right hemicolectomy for colon cancer involving the pancreatic head. Ten cases underwent duodenal diverticularization. One patient with anastomotic leakage healed within 3 weeks. Other patients were cured without postoperative complications. The total 3-and 5-year survival rates after surgery were 53.8% and 9.2%, respectively. Conclusion： The surgical procedure to be performed is usually decided according to the cancer location, extent, and duodenal defect and invasion, which are important for prolonging life time, improving of quality of life and prognosis in these patients.展开更多
The buildings construction safety problems contain various safety-hidden dangers that caused by the human unsafe behaviors, the substance unsafe conditions, operation environment unsafe factors and management defects....The buildings construction safety problems contain various safety-hidden dangers that caused by the human unsafe behaviors, the substance unsafe conditions, operation environment unsafe factors and management defects. The authors summarize comprehensively the problems of buildings construetion safety in China at present based on grasping the whole safety status of buildings construction, and the synthetic countermeasures including the systems about laws, management, technology and education civilization for buildings construction safety management are brought up based on the viewpoint of safety system theory. Then it is thought that huilding scientific management mechanisms and popularizing effective management methods and measures are the fundamental ways for improving further the level of safety management for buildings construction in China at present.展开更多
Objective To discuss the application of semi-precision attachment in restoring a midfacial defect, including a nasal, upper lip, and anterior maxillary defect. Methods A splinted metal-ceramic crowns （from the upper ...Objective To discuss the application of semi-precision attachment in restoring a midfacial defect, including a nasal, upper lip, and anterior maxillary defect. Methods A splinted metal-ceramic crowns （from the upper right first molar to left molar） and a bar with stud attachments was done. A removable partial denture （RPD） containing the patrix portion of the attachment was then designed to restore the missing maxillary anterior teeth and alveolar ridge. Finally,, The facial prosthesis was joined to the denture utilizing two retentive metal posts on the superior aspect of the removable partial. Results A splinted metal-ceramic crowns （from the upper right frst molar to left molar） and a bar with stud attachments was done. A RPD containing the patrix portion of the attachment was then designed to restore the missing maxillary anterior teeth and alveolar ridge. Finally, The facial prosthesis was joined to the denture utilizing two retentive metal posts on the superior aspect of the removable partial. The prosthesis markedly improved the appearance of the patient and demonstrated good retention. Conclusion Using attachment in restoring rnaxillofacial defect may provide adequate retetion which lead to a sucessful treatment outcome.展开更多
Antiretroviral therapy has achieved great success in suppressing human immunodeficiency virus(HIV)replication and transforming HIV infection from a fatal disease to a manageable chronic disease.However,the latent HIV ...Antiretroviral therapy has achieved great success in suppressing human immunodeficiency virus(HIV)replication and transforming HIV infection from a fatal disease to a manageable chronic disease.However,the latent HIV reservoir persists in the body of HIVinfected individuals and is prone to reactivation.Therefore,the development of new treatment methods aimed at a complete cure for HIV is needed.The leading strategy for HIV eradication is based on eliminating and preventing the reactivation of latent reservoirs through an approach known as“shock and kill.”This strategy involves the use of latency-reversing agents(LRAs)to activate the HIV provirus in latent viral reservoir cells.Many LRAs can be obtained from natural resources,including plants and marine organisms.In this review,we provide an overview of natural products used to eliminate HIV latency.展开更多
文摘AIM To investigate the prevalence and related risk factors of birth defects in Shanghai. METHODS This report describes a population-based study of all births at the Obstetrics and Gynecology Hospital of Fudan University in Shanghai, China from January 2008 to December 2014. A logistic regression analysis was used to identify the parameters that are independently associated with birth defects. RESULTS A total of 82814 births, including 824 cases of birth defects, were recorded. The rate of birth defects was 0.995 per 100 births. In the multivariable regression analysis, neonatal birth defects were likely to be associated with higher gravidity [odds ratio(OR), 1.099, 95%CI: 1.024-1.178], premature birth(OR = 1.905, 95%CI: 1.501-2.418), low birth weight(OR = 3.844, 95%CI: 3.004-4.919), twin births or higher order multiple pregnancies(OR = 1.477, 95%CI: 1.107-1.969), cesarean delivery(OR = 1.184, 95%CI: 1.016-1.380) and registration as part of a migrant population(OR = 1.380, 95%CI: 1.167-1.632). Female infants were less likely to have birth defects than male infants(OR = 0.710, 95%CI: 0.616-0.818). CONCLUSION Higher gravidity, premature birth, lower birth weight,twin births or higher order multiple pregnancies, and registration as part of a migrant population are independent predictors of birth defects.
基金funded by the "973" National Social Development Research Program "Dynamic process of cryosphere,the mechanism of cryospheric impacts on climate, hydrology and ecologyadaptation measures" (Grant No.2007CB411507)Science of state key laboratory open fund of "The research of typical basin of cryosphere change and its threshold level,adaptation and strategy"(SKLCS08-04)
文摘This study focuses on the characters of public perceptions on climate and cryosphere change,which are based on a questionnaire survey in the(U|¨)r(u|¨)mqi River Basin.In comparison with scientific observation results of climate and cryosphere change,this paper analyzes the possible impact of the change on water resources and agriculture production in the area.Perceptions of most respondents on climate and cryosphere changes confirm the main objective facts.For the selection of adaptation measures addressing the shortage of water resource,the results are as follows:most people preferred to choose the measures like "policy change" and "basic facility construction" which are mostly implemented by the government and the policy-making department;some people showed more preference to the measures of avoiding unfavorable natural environment,such as finding job in or migrating to other places.The urgency of personal participation in the adaptation measures is still inadequate.Some adaptation measures should be implemented in line with local conditions and require the organic combination of "resource-development" with "water-saving".
文摘The levels of somatostatin(SS)in CSF and blood and pancreatic polypeptide(PP)inplasma were measured by radioimmunoassay in 64 patients with acute ischemiccerebrovascular diseases(ICVD),randomly divided into two groups:group 1(n=31,bothelectro-acupuncture and routine treatments given)and group 2(n=33,routine treatment)and 26 non-ICVD patients were used as controls.The points of electro-acupuncture wereQuchi(LI 12),Waiguan(SJ 5)and Huantiao(GB 30)and Zusanli(St 36).After a courseof treatment,the SS levels in plasma and CSF were significantly increased in the patientsof group 1 with good result and their plasma PP level had no significant change.In thepatients with poor result,however,the PP level was significantly decreased.The resultssuggested that electro-acupuncture might play an active role in alleviating the SSmetabolic disturbance in CNS of ICVD patients.
基金National Key Technology R&D Program,China(No.2009BAI81B02)PhD Programs Foundation of Ministry of Education of China(No.20070287055)Anhui Natural Science Foundation,China(No.1308085QE93)
文摘The research and application on small denture machining equipment are great breakthrough for modern dental restoration technology. In this paper, a small denture machining equipment made of two spindles with four-axis was designed based on machining characteristics and functional analysis. Position accuracy and re-position accuracy were measured by accuracy instrument. In order to test its machining capacity, some typical microstcucture parts, such as straight channel, hemispherical surface, and molars coronal, were selected for high speed milling. It was obtained that the denture machining equipment met the machining requirements with high quality and efficiency, according to the acquisition and analysis of form and position errors, surface roughness, and 3-D profile.
基金Supported by National Natural Science Foundation of China(81400774)PUMC Youth Fund(33320140164 and 3332016128)
文摘Objective To evaluate physicians' attitude and knowledge about the management of adult growth hormone deficiency(AGHD) at Peking Union Medical College Hospital and impact factors associated with better decision-making.Methods A 21-question anonymous survey was distributed and collected at Peking Union Medical College Hospital,a major teaching hospital in Chinese Academy of Medical Sciences.Data of physicians' educational background,clinical training,patient workload per year and continuing medical education in AGHD were collected.Factors associated with appropriate answers were further analyzed by multivariate regression models.Results One hundred and eighteen internal medicine residents,endocrine fellows,attending physicians and visiting physicians responded to the survey.Among them,44.9% thought that AGHD patients should accept recombinant human growth hormone replacement therapy.Moreover,56.8% selected insulin tolerance test and growth hormone-releasing hormone-arginine test for the diagnosis of AGHD.Logistic regression analysis of physician demographic data,educational background,and work experience found no consistent independent factors associated with better decision-making,other than continued medical education,that were associated with treatment choice.Conclusions The physicians' reported management of AGHD in this major academic healthcare center in Beijing was inconsistent with current evidence.High quality continued medical education is required to improve Chinese physician management of AGHD.
文摘Objective： The aim of the study was to discuss surgical treatment of right colon carcinoma of hepatic flexure invading the duodenum. Methods： The 65 patients with right colon carcinoma of hepatic flexure invading the duodenum, treated in our department from 1987 to 2007, were included in this study. Their clinicopathological data were retrospectively reviewed and analyzed. All the cases were divided into three types （local invasion, regional invasion, and cancer with internal fistula） according to duodenal defect, including local invasion （ 2.0 cm）, wide invasion （ 2.0 cm） and the presence of internal fistula. Results： The 25 patients with local invasion underwent en bloc resection of the duodenal wall. Pedicled ileal flap was used to cover the large duodenal defect measuring 2.0–3.0 cm in 5 patients. Dudenojejunostomy was used to reconstruct the large defect measuring more than 5 cm in 3 patients. Conservative resection of right-sided colon was performed in 18 patients with wide invasion. Four patients underwent pancreaticoduodenectomy combined with right hemicolectomy for colon cancer involving the pancreatic head. Ten cases underwent duodenal diverticularization. One patient with anastomotic leakage healed within 3 weeks. Other patients were cured without postoperative complications. The total 3-and 5-year survival rates after surgery were 53.8% and 9.2%, respectively. Conclusion： The surgical procedure to be performed is usually decided according to the cancer location, extent, and duodenal defect and invasion, which are important for prolonging life time, improving of quality of life and prognosis in these patients.
基金A Project Supported by Scientific Research Fund of Hunan Provincial Education Department(06C309)
文摘The buildings construction safety problems contain various safety-hidden dangers that caused by the human unsafe behaviors, the substance unsafe conditions, operation environment unsafe factors and management defects. The authors summarize comprehensively the problems of buildings construetion safety in China at present based on grasping the whole safety status of buildings construction, and the synthetic countermeasures including the systems about laws, management, technology and education civilization for buildings construction safety management are brought up based on the viewpoint of safety system theory. Then it is thought that huilding scientific management mechanisms and popularizing effective management methods and measures are the fundamental ways for improving further the level of safety management for buildings construction in China at present.
基金grant of Shanghai Leading Academic Discipline Fund(T0202)
文摘Objective To discuss the application of semi-precision attachment in restoring a midfacial defect, including a nasal, upper lip, and anterior maxillary defect. Methods A splinted metal-ceramic crowns （from the upper right first molar to left molar） and a bar with stud attachments was done. A removable partial denture （RPD） containing the patrix portion of the attachment was then designed to restore the missing maxillary anterior teeth and alveolar ridge. Finally,, The facial prosthesis was joined to the denture utilizing two retentive metal posts on the superior aspect of the removable partial. Results A splinted metal-ceramic crowns （from the upper right frst molar to left molar） and a bar with stud attachments was done. A RPD containing the patrix portion of the attachment was then designed to restore the missing maxillary anterior teeth and alveolar ridge. Finally, The facial prosthesis was joined to the denture utilizing two retentive metal posts on the superior aspect of the removable partial. The prosthesis markedly improved the appearance of the patient and demonstrated good retention. Conclusion Using attachment in restoring rnaxillofacial defect may provide adequate retetion which lead to a sucessful treatment outcome.
基金supported by the Japan Society for the Promotion of Science KAKENHI 17K08348 and 21K06619(Wei Li).
文摘Antiretroviral therapy has achieved great success in suppressing human immunodeficiency virus(HIV)replication and transforming HIV infection from a fatal disease to a manageable chronic disease.However,the latent HIV reservoir persists in the body of HIVinfected individuals and is prone to reactivation.Therefore,the development of new treatment methods aimed at a complete cure for HIV is needed.The leading strategy for HIV eradication is based on eliminating and preventing the reactivation of latent reservoirs through an approach known as“shock and kill.”This strategy involves the use of latency-reversing agents(LRAs)to activate the HIV provirus in latent viral reservoir cells.Many LRAs can be obtained from natural resources,including plants and marine organisms.In this review,we provide an overview of natural products used to eliminate HIV latency.
