Horizontal cells (HCs) mediate negative feedback to photoreceptors. In the mammalian retina, there are two types of HCs, which are extensively coupled to neighboring cells through homologous gap junctions. The permeab...Horizontal cells (HCs) mediate negative feedback to photoreceptors. In the mammalian retina, there are two types of HCs, which are extensively coupled to neighboring cells through homologous gap junctions. The permeability and therefore the strength of feedback can be regulated by light intensity, dopamine and many other factors. However, the component(s) of the most prominent gap junctions, those between A-type HCs in the rabbit retina, is still unknown. In this study, we compared the sequences of many types of mammalian connexins, obtained partial sequences of rabbit connexin 50 and 57. Using specific primers designed against the rabbit sequences, we identified mRNAs of connexin 50 and/or 57 in visually selected single A-type HC using multiplex RT-PCR.展开更多
The probability of long-range connection among neurons could be changeable in biological neuronal networks. In this paper, the probability of long-range connection between neurons is not fixed at a constant but varies...The probability of long-range connection among neurons could be changeable in biological neuronal networks. In this paper, the probability of long-range connection between neurons is not fixed at a constant but varies in a numerical region (≤p0 ), and then the collective behaviors of neurons are detected. A statistical factor in the two-dimensional space is used to detect the phase transition and robustness of spiral wave in the active network of neurons. It is found that the development of spatiotem-poral pattern depends on the numerical region (≤p0 ) for the probability of long-range connection. Coherence resonance-like behavior is observed due to the fluctuation in the long-range probability. Spiral waves emerge to occupy the network of neurons under an optimized probability of long-range connection, and it shows certain robustness in weak channel noise.展开更多
基金supported by a MOST Major State Basic Research Program Grant to the Institute of Neuroscience(G2000077800)NSFC project grants(30170305,30270460)to SH
文摘Horizontal cells (HCs) mediate negative feedback to photoreceptors. In the mammalian retina, there are two types of HCs, which are extensively coupled to neighboring cells through homologous gap junctions. The permeability and therefore the strength of feedback can be regulated by light intensity, dopamine and many other factors. However, the component(s) of the most prominent gap junctions, those between A-type HCs in the rabbit retina, is still unknown. In this study, we compared the sequences of many types of mammalian connexins, obtained partial sequences of rabbit connexin 50 and 57. Using specific primers designed against the rabbit sequences, we identified mRNAs of connexin 50 and/or 57 in visually selected single A-type HC using multiplex RT-PCR.
基金supported by the National Nature Science Foundation of China (Grant Nos.11265008 and 10972179)
文摘The probability of long-range connection among neurons could be changeable in biological neuronal networks. In this paper, the probability of long-range connection between neurons is not fixed at a constant but varies in a numerical region (≤p0 ), and then the collective behaviors of neurons are detected. A statistical factor in the two-dimensional space is used to detect the phase transition and robustness of spiral wave in the active network of neurons. It is found that the development of spatiotem-poral pattern depends on the numerical region (≤p0 ) for the probability of long-range connection. Coherence resonance-like behavior is observed due to the fluctuation in the long-range probability. Spiral waves emerge to occupy the network of neurons under an optimized probability of long-range connection, and it shows certain robustness in weak channel noise.
