The eponymous site is located in the territory of Poland--the northern part of the central section of the Stupia river, about 30 km from the coast of the Baltic sea. The site of Losino 15 revealed some traces of a set...The eponymous site is located in the territory of Poland--the northern part of the central section of the Stupia river, about 30 km from the coast of the Baltic sea. The site of Losino 15 revealed some traces of a settlement of the Pomeranian and the Wielbark cultures. The most interesting features discovered at the study site are the remains of bloomery furnaces. The site of Losino 15 yielded 10 features interpreted as relics of the bloomery shaft furnace with a pit. They were characterized by a high degree of deterioration-due to the agronomic activities and slope processes, only the bottom part of the slag-pit have been preserved. These are the remains of shaft furnaces with a pit called slag-pit fumace, whose relics are slag-pits filled with slag. The site of Losino 15 yielded slag with a total weight of about 100 kg. Two alternative and temporarily equivalent hypotheses can be proposed here. According to the former one, the creators of the bloomery were representatives of the Pomeranian culture, and in the latter version--they represented the Wielbark culture.展开更多
In the present study, we aimed to explore the mechanism of Salvia miltiorrhiza in the treatment of pathological scars(PS) by network pharmacology. The active ingredients and drug targets of Salvia miltiorrhiza were sc...In the present study, we aimed to explore the mechanism of Salvia miltiorrhiza in the treatment of pathological scars(PS) by network pharmacology. The active ingredients and drug targets of Salvia miltiorrhiza were screened out through TCMSP database, the disease targets of PS in Gene Cards database were obtained, and Venn diagram analysis on drug targets and disease targets was performed, and the intersection was used as the target of Salvia miltiorrhiza for the treatment of PS. Cytoscape software was used to construct a drug-ingredient-target-disease network diagram. A protein-protein interaction network was constructed through String website, its key protein modules and hub genes were screened with Cytoscape software, and GO and KEGG enrichment analyses were performed in DAVID database. Fifty-nine active ingredients, 138 drug targets, and 90 targets of Salvia miltiorrhiza for the treatment of PS were screened out. Core ingredients, such as luteolin and tanshinone IIA, were obtained. The hub genes, such as VEGFA, TP53, JUN, STAT3, AKT1, MAPK1, and PTGS2, and signaling pathways, such as HIF-1, TNF, MAPK, PI3 K-Akt, and Jak-STAT, were screened out. Salvia miltiorrhiza might improve PS hypoxia, inflammation, and balance of proliferation and apoptosis of fibroblasts by regulating HIF-1, TNF, MAPK, PI3 K-Akt, and Jak-STAT signaling pathways. Moreover, it had the characteristics of multiple centers, multiple targets, and multiple pathways.展开更多
文摘The eponymous site is located in the territory of Poland--the northern part of the central section of the Stupia river, about 30 km from the coast of the Baltic sea. The site of Losino 15 revealed some traces of a settlement of the Pomeranian and the Wielbark cultures. The most interesting features discovered at the study site are the remains of bloomery furnaces. The site of Losino 15 yielded 10 features interpreted as relics of the bloomery shaft furnace with a pit. They were characterized by a high degree of deterioration-due to the agronomic activities and slope processes, only the bottom part of the slag-pit have been preserved. These are the remains of shaft furnaces with a pit called slag-pit fumace, whose relics are slag-pits filled with slag. The site of Losino 15 yielded slag with a total weight of about 100 kg. Two alternative and temporarily equivalent hypotheses can be proposed here. According to the former one, the creators of the bloomery were representatives of the Pomeranian culture, and in the latter version--they represented the Wielbark culture.
基金The National Key Research and Development Projects(Grant No.2017YFC1307602)the Scientific Research Projects of Tianjin(Grant No.16ZXHLSY00120+2 种基金15ZXLCSY00040)Logistics College of PAP Projects(Grant No.WHJ201729)Logistics Project of PAP(Grant No.CWJ18L004)。
文摘In the present study, we aimed to explore the mechanism of Salvia miltiorrhiza in the treatment of pathological scars(PS) by network pharmacology. The active ingredients and drug targets of Salvia miltiorrhiza were screened out through TCMSP database, the disease targets of PS in Gene Cards database were obtained, and Venn diagram analysis on drug targets and disease targets was performed, and the intersection was used as the target of Salvia miltiorrhiza for the treatment of PS. Cytoscape software was used to construct a drug-ingredient-target-disease network diagram. A protein-protein interaction network was constructed through String website, its key protein modules and hub genes were screened with Cytoscape software, and GO and KEGG enrichment analyses were performed in DAVID database. Fifty-nine active ingredients, 138 drug targets, and 90 targets of Salvia miltiorrhiza for the treatment of PS were screened out. Core ingredients, such as luteolin and tanshinone IIA, were obtained. The hub genes, such as VEGFA, TP53, JUN, STAT3, AKT1, MAPK1, and PTGS2, and signaling pathways, such as HIF-1, TNF, MAPK, PI3 K-Akt, and Jak-STAT, were screened out. Salvia miltiorrhiza might improve PS hypoxia, inflammation, and balance of proliferation and apoptosis of fibroblasts by regulating HIF-1, TNF, MAPK, PI3 K-Akt, and Jak-STAT signaling pathways. Moreover, it had the characteristics of multiple centers, multiple targets, and multiple pathways.
