lntemet services on bioinformatics still remain a popular tool for the researchers. Here the authors present a recently developed web-site http：//bri-shur.com where several tools and pipelines for protein structure p...lntemet services on bioinformatics still remain a popular tool for the researchers. Here the authors present a recently developed web-site http：//bri-shur.com where several tools and pipelines for protein structure prediction are implemented. The prediction of a structure for a particular protein often requires a sensitive and iterative approach, and the web-site provides an environment for this kind of work. Software that is used in the services includes both free programs available in the Internet and newly developed algorithms. The service on homology screening in PDB for a structure template is implemented using an approach that is alternative to well-known BLAST algorithm and it has some advantages over BLAST. The service on homology modeling uses well-known Nest program. The service on protein energy estimate allows selecting a best template in the set of homologs and adds a functionality of fold recognition to the environment. The design of the site simplifies several of the most useful bioinformatics routines, thus making them available to a large community of researchers. Services are provided free of charge without registration, and the user＇s privacy is taken care of.展开更多
The objective of Performance-Based Earthquake Engineering （PBEE） is the analysis of performance objectives with a specified annual probability of exceedance. Increasingly undesirable performance is caused by increas...The objective of Performance-Based Earthquake Engineering （PBEE） is the analysis of performance objectives with a specified annual probability of exceedance. Increasingly undesirable performance is caused by increasing levels of strong ground motion having decreasing annual probabilities of exceedance. The development of this methodology includes three steps： （1） evaluation of the distribution of ground motion at a site; （2） evaluation of the distribution of system response; （3） evaluation of the probability of exceeding decision variables within a given time period, given appropriate damage measures. The work has taken a systematic approach to determine the impact of increasing levels of detail in site characterization on the accuracy of ground motion and site effects predictions. Complementary studies have investigated the use of the following models for evaluating site effects： （1） amplification factors defined on the basis of generalized site categories, （2） one-dimensional ground response analysis, and （3） two-dimensional ground response analysis for surface topography on ground motion. The paper provides a brief synthesis of ground motion and site effects analysis procedures within a Performance-Based Design framework. It focuses about the influence on the evaluation of site effects in some active regions by different shear waves velocity measurements Down Hole （D-H）, Cross Hole （C-H）, Seismic Dilatometer Marchetti Test （SDMT） and by different variation of shear modulus and damping ratio with strain level and depth from different laboratory dynamic tests for soil characterization： Resonant Column Test （RCT）, Cyclic Loading Torsional Shear Test （CLTST）.展开更多
文摘lntemet services on bioinformatics still remain a popular tool for the researchers. Here the authors present a recently developed web-site http：//bri-shur.com where several tools and pipelines for protein structure prediction are implemented. The prediction of a structure for a particular protein often requires a sensitive and iterative approach, and the web-site provides an environment for this kind of work. Software that is used in the services includes both free programs available in the Internet and newly developed algorithms. The service on homology screening in PDB for a structure template is implemented using an approach that is alternative to well-known BLAST algorithm and it has some advantages over BLAST. The service on homology modeling uses well-known Nest program. The service on protein energy estimate allows selecting a best template in the set of homologs and adds a functionality of fold recognition to the environment. The design of the site simplifies several of the most useful bioinformatics routines, thus making them available to a large community of researchers. Services are provided free of charge without registration, and the user＇s privacy is taken care of.
文摘The objective of Performance-Based Earthquake Engineering （PBEE） is the analysis of performance objectives with a specified annual probability of exceedance. Increasingly undesirable performance is caused by increasing levels of strong ground motion having decreasing annual probabilities of exceedance. The development of this methodology includes three steps： （1） evaluation of the distribution of ground motion at a site; （2） evaluation of the distribution of system response; （3） evaluation of the probability of exceeding decision variables within a given time period, given appropriate damage measures. The work has taken a systematic approach to determine the impact of increasing levels of detail in site characterization on the accuracy of ground motion and site effects predictions. Complementary studies have investigated the use of the following models for evaluating site effects： （1） amplification factors defined on the basis of generalized site categories, （2） one-dimensional ground response analysis, and （3） two-dimensional ground response analysis for surface topography on ground motion. The paper provides a brief synthesis of ground motion and site effects analysis procedures within a Performance-Based Design framework. It focuses about the influence on the evaluation of site effects in some active regions by different shear waves velocity measurements Down Hole （D-H）, Cross Hole （C-H）, Seismic Dilatometer Marchetti Test （SDMT） and by different variation of shear modulus and damping ratio with strain level and depth from different laboratory dynamic tests for soil characterization： Resonant Column Test （RCT）, Cyclic Loading Torsional Shear Test （CLTST）.
