Background Nicorandil （NIC） is a vasodilatory drug used to treat angina. However, its efficacy of cardioprotection in coronary mi- croembolization （CME） is largely unknown. This study was undertaken to determine w...Background Nicorandil （NIC） is a vasodilatory drug used to treat angina. However, its efficacy of cardioprotection in coronary mi- croembolization （CME） is largely unknown. This study was undertaken to determine whether nicorandil pretreatment could attenuate myo- cardial apoptosis and improve cardiac function after CME in rats. Methods Forty-five rats were randomly divided into a Sham group, a CME group and a CME ＋ NIC （NIC） group （n = 15 per group）. CME was established by injecting plastic microspheres （42 pm in diameter） into the left ventricle of the rats in all of the groups except the Sham group. The NIC group received nicorandil at 3 mg/kg per day for seven days before the operation. Cardiac fimction was assessed by echocardiography, the expression levels of cleaved caspase-9/8/3 were detected by Western blot, microinfarction area was measured by haematoxylin-basic fuchsin picric acid staining, and myocardial apoptosis was de- tected by TUNEL staining. Results Compared to that in the Sham group, cardiac fimction in the CME group was significantly decreased （P 〈 0.05）. However, compared to the CME group, the NIC group showed improved cardiac function （P 〈 0.05）. The expression levels of cleaved caspase-9/8/3 protein and myocardial apoptosis were dramatically increased in the CME group compared to those in the Sham group （P 〈 0.05）, while the NIC pretreatment group had significantly decreased expression levels of cleaved caspase-9/8/3 protein as well as a de- creased apoptotic rate （P 〈 0.05）. Conclusions NIC pretreatment inhibited CME-induced myocardial apoptosis and improved cardiac func- tion through blockade of the mitochondrial and death receptor-mediated apoptotic pathways.展开更多
Publish/subscribe(pub/sub) paradigm is the main communication model for Information-Centric Network(ICN) proposals.A key issue for pub/sub system is how to route the content objects to the correct subscribers,and ICN ...Publish/subscribe(pub/sub) paradigm is the main communication model for Information-Centric Network(ICN) proposals.A key issue for pub/sub system is how to route the content objects to the correct subscribers,and ICN is no exception.ICN network would be divided into core domain and many edge domains as today's internet does.HHR(Hierarchy Hybrid Routing scheme) is presented for ICN:A Chord-like routing scheme is used in core domain,while edge domains routing structure can be classified into three categories,Local Routing(LR),Delivery of Local Publication to Core domain(DLPC),and Remote Publication Routing into edge domain(RPR).LR can be decided by each edge domain,which determined by many factors,such as locality characteristic for pub/sub information and local policies.A hierarchical routing algorithm is proposed to solve DLPC and RPR simultaneously.Simulation results demonstrate that HHR can be fast deployed,and can be applied in large scale network or dynamic subscription environment.展开更多
A novel lossless information hiding algorithm based on wavelet neural network for digital vector maps is introduced. Wavelet coefficients being manipulated are embedded into a vector map, which could be restored by ad...A novel lossless information hiding algorithm based on wavelet neural network for digital vector maps is introduced. Wavelet coefficients being manipulated are embedded into a vector map, which could be restored by adjusting the weights of neurons in the designed neural network. When extracting the watermark extraction, those coefficients would be extracted by wavelet decomposition. With the trained multilayer feed forward neural network, the watermark would be obtained finally by measuring the weights of neurons. Experimental results show that the average error coding rate is only 6% for the proposed scheme and compared with other classical algorithms on the same tests, it is indicated that the proposed algorithm hashigher robustness, better invisibility and less loss on precision.展开更多
基金This work received the support of the National Natural Science Foundation of China （Grant No. 81600283） and the Guangxi Natural Science Foundation （Grant No. 2016 GXNSFBA380022）.
文摘Background Nicorandil （NIC） is a vasodilatory drug used to treat angina. However, its efficacy of cardioprotection in coronary mi- croembolization （CME） is largely unknown. This study was undertaken to determine whether nicorandil pretreatment could attenuate myo- cardial apoptosis and improve cardiac function after CME in rats. Methods Forty-five rats were randomly divided into a Sham group, a CME group and a CME ＋ NIC （NIC） group （n = 15 per group）. CME was established by injecting plastic microspheres （42 pm in diameter） into the left ventricle of the rats in all of the groups except the Sham group. The NIC group received nicorandil at 3 mg/kg per day for seven days before the operation. Cardiac fimction was assessed by echocardiography, the expression levels of cleaved caspase-9/8/3 were detected by Western blot, microinfarction area was measured by haematoxylin-basic fuchsin picric acid staining, and myocardial apoptosis was de- tected by TUNEL staining. Results Compared to that in the Sham group, cardiac fimction in the CME group was significantly decreased （P 〈 0.05）. However, compared to the CME group, the NIC group showed improved cardiac function （P 〈 0.05）. The expression levels of cleaved caspase-9/8/3 protein and myocardial apoptosis were dramatically increased in the CME group compared to those in the Sham group （P 〈 0.05）, while the NIC pretreatment group had significantly decreased expression levels of cleaved caspase-9/8/3 protein as well as a de- creased apoptotic rate （P 〈 0.05）. Conclusions NIC pretreatment inhibited CME-induced myocardial apoptosis and improved cardiac func- tion through blockade of the mitochondrial and death receptor-mediated apoptotic pathways.
基金supported by 973 Program(2013CB329103)NSFC Fund (61271165,61301153)Program for Changjiang Scholars and Innovative Research Team (PCSIRT) in University and the 111 Project B14039
文摘Publish/subscribe(pub/sub) paradigm is the main communication model for Information-Centric Network(ICN) proposals.A key issue for pub/sub system is how to route the content objects to the correct subscribers,and ICN is no exception.ICN network would be divided into core domain and many edge domains as today's internet does.HHR(Hierarchy Hybrid Routing scheme) is presented for ICN:A Chord-like routing scheme is used in core domain,while edge domains routing structure can be classified into three categories,Local Routing(LR),Delivery of Local Publication to Core domain(DLPC),and Remote Publication Routing into edge domain(RPR).LR can be decided by each edge domain,which determined by many factors,such as locality characteristic for pub/sub information and local policies.A hierarchical routing algorithm is proposed to solve DLPC and RPR simultaneously.Simulation results demonstrate that HHR can be fast deployed,and can be applied in large scale network or dynamic subscription environment.
文摘A novel lossless information hiding algorithm based on wavelet neural network for digital vector maps is introduced. Wavelet coefficients being manipulated are embedded into a vector map, which could be restored by adjusting the weights of neurons in the designed neural network. When extracting the watermark extraction, those coefficients would be extracted by wavelet decomposition. With the trained multilayer feed forward neural network, the watermark would be obtained finally by measuring the weights of neurons. Experimental results show that the average error coding rate is only 6% for the proposed scheme and compared with other classical algorithms on the same tests, it is indicated that the proposed algorithm hashigher robustness, better invisibility and less loss on precision.
