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广州市市立博物院创始人黄节与罗原觉交往简述
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作者 程存洁 《广州文博》 2016年第1期306-335,6,共31页
黄节与罗原觉二人均是广州市市立博物院的创始人。1995年8月,罗原觉先生的女公子罗德慈先生向广州博物馆捐献了一批家藏文物。在这批文物中,有廿封黄节致罗原觉的信函。本文通过整理考释这批信函,真实地再现了黄节与罗原觉长达数十年的... 黄节与罗原觉二人均是广州市市立博物院的创始人。1995年8月,罗原觉先生的女公子罗德慈先生向广州博物馆捐献了一批家藏文物。在这批文物中,有廿封黄节致罗原觉的信函。本文通过整理考释这批信函,真实地再现了黄节与罗原觉长达数十年的交往,以及结下的深厚友谊。这批信函还为人们了解黄节在不同时期工作、生活和教学状况以及个人生活情趣,提供了第一手材料。 展开更多
关键词 教学 状况 博物院 先生 广州市 罗原 文物 信函 生活
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The role of wild goose(Anser) populations of Russia and theTibet Plateau in the spread of the avian influenza virus 被引量:2
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作者 Mariya V.SIVAY Nikita Y.SILKO +5 位作者 Kirill A.SHARSHOV Aleksander V.PROKUDIN 李来兴 杨敏 操胜 Aleksander M.SHESTOPALOV 《Chinese Birds》 2011年第3期140-146,共7页
Wild birds of the orders Anseriformes and Charadriiformes represent a natural reservoir of low pathogenic avian influenza(LPAI) viruses(family Orthomyxoviridae).Wild geese(order Anseriformes)relating to waterfowls und... Wild birds of the orders Anseriformes and Charadriiformes represent a natural reservoir of low pathogenic avian influenza(LPAI) viruses(family Orthomyxoviridae).Wild geese(order Anseriformes)relating to waterfowls undertake extensive migration flights reaching thousands of kilometers.Isolation of the avian influenza virus(AIV) from wild geese is quite low or absent.The aims of this study are to monitor the AIV in different wild goose species,nesting on Russian territory and the Tibet Plateau and to analyze the derived data for the purpose of determining the role of these wild bird species in spreading pathogens.In our study 3245 samples from nine wild goose species in nine regions of Russia and on the territory of the Tibet Plateau(the Xizang Autonomous Region) were tested and no AIV were detected.Our study shows the non-essential role of wild geese in the spread of the AIV over long distances and reaches theconclusion that geese are probably not natural reservoirs for the primary viruses.However,further inquiry of AIV in wild goose populations is required.Studies of wild geese and AIV ecology will allow us to obtainmore information about pathogen-host relationships and to make arrangements for the maintenance ofwild goose populations. 展开更多
关键词 avian influenza virus wild geese RUSSIA Tibet Plateau
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Effect of Uncertainty of Grid DEM on TOPMODEL:Evaluation and Analysis 被引量:1
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作者 WANG Peifa DU Jinkang +1 位作者 FENG Xuezhi KANG Guoding 《Chinese Geographical Science》 SCIE CSCD 2006年第4期320-326,共7页
TOPMODEL,a semi-distributed hydrological model,has been widely used.In the process of simulation of the model,Digital Elevation Model(DEM) is used to provide the input data,such as topographic index and distance to th... TOPMODEL,a semi-distributed hydrological model,has been widely used.In the process of simulation of the model,Digital Elevation Model(DEM) is used to provide the input data,such as topographic index and distance to the drainage outlet;thus DEM plays an important role in TOPMODEL.This study aims at examining the impacts of DEM uncertainty on the simulation results of TOPMODEL.In this paper,the effects were evaluated mainly from quantitative and qualitative aspects.Firstly,DEM uncertainty was simulated by using the Monte Carlo method,and for every DEM realization,the topographic index and distance to the drainage outlet were extracted.Secondly,the obtained topographic index and the distance to the drainage outlet were input to the TOPMODEL to simulate seven rain-storm-flood events,and four evaluation indices,such as Nash and Sutcliffe efficiency criterion(EFF),sum of squared residuals over all time steps(SSE),sum of squared log residuals over all time steps(SLE) and sum of absolute errors over all time steps(SAE) were recorded.Thirdly,these four evaluation indices were analyzed in statistical manner(minimum,maximum,range,standard deviation and mean value),and effect of DEM uncertainty on TOPMODEL was quantitatively analyzed.Finally,the simulated hydrographs from TOPMODEL using the original DEM and realizations of DEM were qualitatively evaluated under each flood cases.Results show that the effect of DEM uncertainty on TOPMODEL is inconsiderable and could be ignored in the model’s application.This can be explained by:1) TOPMODEL is not sensitive to the distribution of topographic index and distance to the drainage outlet;2) the distri-bution of topographic index and distance to the drainage outlet are slightly affected by DEM uncertainty. 展开更多
关键词 DEM uncertainty TOPMODEL Monte Carlo simulation Jiaokou watershed
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Monte Carlo method in optical atomic force microscopy
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作者 Ahemd ElMelegy Sarwat Zahwi 《Journal of Measurement Science and Instrumentation》 CAS CSCD 2021年第3期267-271,共5页
Scanning probe microscopy(SPM)is a branch of microscopy that forms images of surfaces using a physical probe that scans the specimen.Atomic force microscopy is one of the SPM family which is considered as a very versa... Scanning probe microscopy(SPM)is a branch of microscopy that forms images of surfaces using a physical probe that scans the specimen.Atomic force microscopy is one of the SPM family which is considered as a very versatile tool for surface imaging and measurements.A wide range of various samples can be measured regardless of being conductive,no-conductive,in vacuum,in air or in a fluid as a unique feature.One of the most challenges in atomic force microscopes(AFMs)is to evaluate the associated uncertainty during the surface measurements by AFMs.Here,an optical AFM is calibrated through the calibration of XYZ stage.The approach is to overcome difficulties experienced when trying to evaluate some uncertainty components which cannot be experimentally determined i.e.tip surface interaction forces and tip geometry.The Monte Carlo method is then used to determine the associated uncertainties due to such factors by randomly drawing the parameters according to their associated tolerances and their probability density functions(PDFs).The whole process follows supplement 2 to“the guide to the expression of the uncertainty in measurement”(GUM).The approach validated in the paper shows that the evaluated uncertainty in AFM is about 10 nm. 展开更多
关键词 MEASUREMENT Monte Carlo method atomic force microscope(AFM) NANOMETROLOGY
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The Art of Authenticity: Constantin Stanislavski and Merleau-Ponty
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作者 Robert F. Mullen 《Journal of Literature and Art Studies》 2016年第7期790-803,共14页
Constantin Stanislavski's Russian acting system, further developed by contemporary methodological practices, and Maurice Merleau-Ponty's philosophy of the body as object-subject are compared to illustrate how simple... Constantin Stanislavski's Russian acting system, further developed by contemporary methodological practices, and Maurice Merleau-Ponty's philosophy of the body as object-subject are compared to illustrate how simple, learned techniques can assist in the production of authentic and transparent interrelational presence. Authentic presence requires three components: (1) honest exposition of a person's singular, essential being; (2) empathy towards the needs of other, distinct and separate from the self; and (3) mutual reciprocation, which means giving back or responding somewhat equitably to the other with whom the self is in communication, and accepting the same respondence from the other if afforded. The comprehension of Merleau-Ponty's ontology combined with Stanislavski's performance technique is uniquely suited to interpersonal communications in the 'real world'. Stanislavski's artistic vision demands an intensity of attentive involvement in order to achieve onstage authenticity. Merleau-Ponty provides supportive philosophical schematics, especially in his controversial but effective use of the expression 'flesh'. While this study may initially appear to focus on the artist, the development of interrelational skills is reliably applicable to anyone who desires to obtain a higher degree of authenticity in collaborative presence. 展开更多
关键词 AUTHENTICITY EMBODIMENT INTERPERSONAL MERLEAU-PONTY PRESENCE Stanislavski subject/object
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Angular Distributions for φ' Sequential Decays into 2(π^+π^-)pp^-γ via XCJ
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作者 PING Rong-Gang 《Communications in Theoretical Physics》 SCIE CAS CSCD 2005年第6X期1050-1054,共5页
Amplitudes for φ(2S) sequential decays into 2(π^+π^-)pp^-γ via XCJ are constructed in effective coupling scheme. A Mote-Carlo simulation is carried out to study angular distributions of the decayed particles ... Amplitudes for φ(2S) sequential decays into 2(π^+π^-)pp^-γ via XCJ are constructed in effective coupling scheme. A Mote-Carlo simulation is carried out to study angular distributions of the decayed particles in laboratory system. The results can be taken as a reference for measuring the decay of XCJ into at BESⅡ/BEPC in the near future. 展开更多
关键词 charmonium decays Monte-Carlo simulation invanant amplitudes
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A Monte Carlo Simulation of Radiation Damage of SiC and Nb Using JA-IPU Code 被引量:1
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作者 Nagendra Singh Raghaw Vinod Kumar +2 位作者 Ambika Tundwal Yury Korovin Jindrich Adam 《Journal of Energy and Power Engineering》 2015年第11期967-975,共9页
MC (Monte Carlo) simulation code, JA-IPU is used to study radiation damage of SiC irradiated to spallation neutron and AmBe neutron spectra. The code is based on the major physical processes of radiation damage on i... MC (Monte Carlo) simulation code, JA-IPU is used to study radiation damage of SiC irradiated to spallation neutron and AmBe neutron spectra. The code is based on the major physical processes of radiation damage on incorporation of atomic collision cascade and limited to 10 MeV neutron energy. A phenomenological relation for radiation swelling is also derived. Based on the calculation of swelling, DPA (displacement per atom), defect production efficiency and effective threshold energy, Efff from the data of MC simulation, SiC is inferred to be a highly radiation resistant material when compared with Nb and Ni metals which are used in composition of several reactor steels. Experimental results of hill-hock density measured using AFM (atomic force microscopy), also confirm radiation resistant behavior of SiC. 展开更多
关键词 Monte-Carlo simulation radiation resistant material DPA effective damage threshold energy.
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Physical Status of Soils Developed from Loesslike Loams in the Southwest of the Central Russian Plain (the Belogor'e Reserve)
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作者 Oleg Romanov 《Journal of Environmental Science and Engineering(B)》 2014年第6期300-303,共4页
Soils developed from the Quaternary loesslike loams have been studied in the south of the forest-steppe zone on the Central Russian Upland. A polygenetic nature of the soil profile on the loesslike loams is shown. The... Soils developed from the Quaternary loesslike loams have been studied in the south of the forest-steppe zone on the Central Russian Upland. A polygenetic nature of the soil profile on the loesslike loams is shown. The modem pedogenetic processes in this soil ensure its eluvial-illuvial differentiation with the development of multilayered coatings in the illuvial horizon. The middle horizons in the studied soil profiles are referred to as textural (clay-illuvial) horizons. Differences in physical soil properties (bulk density, airconductivity, texture, water content, and temperature dynamics) were studied in the soil on the loesslike loam. 展开更多
关键词 Physical soil properties bulk density texture water content loesslike loam.
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Remuneration Reforms in Public Sector: A Case of Russian Healthcare
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作者 Marina Kolosnitsyna 《Chinese Business Review》 2012年第1期109-118,共10页
In 2008 remuneration reform for public sector was introduced in Russia. Its main idea was to implement P4P principle well-known in business, including more flexible approach to wage setting. This paper presents an att... In 2008 remuneration reform for public sector was introduced in Russia. Its main idea was to implement P4P principle well-known in business, including more flexible approach to wage setting. This paper presents an attempt to estimate an influence of the new remuneration system (NRS) on earnings level, inequalities and job motivation. The estimates are based on microdata of monitoring survey of healthcare economic problems conducted in Russia in 2009 and 2010. The extended specification of Mincer earning equation and probit-models were used. One could observe increasing wage rates and earning inequalities within healthcare institutions adopted NRS though worker's experience and regional economic differences remain significant wage determining factors. As it occurs, NRS is widely adopted by large regional and central hospitals while smaller health care institutions show less enthusiasm in implementing reform. Obviously, the larger institutions have more money and better educated administrative staff to introduce the new system. Those chief physicians who adopted NRS point out a positive correlation between earnings and individual input. At the same time, those committed to old principles of wage setting more often note declining job turnover. This latter result could possibly indicate negative personnel sorting, less productive workers tending to stay with employer who doesn't assess their performance. As concerns anticipated NRS results such as increasing motivation and quality of health services, the evidence is still ambiguous. 展开更多
关键词 remuneration system pay for performance health care institutions job motivation
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Mycotoxins in Brewing Grain Raw Material (Barley, Malt) in Russia
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作者 Tatiana Volkova 《Journal of Food Science and Engineering》 2013年第9期496-502,共7页
The levels of five mycotoxins (MT): deoxynivalenol (DON), T-2-toxin (T-2), zearalenone (ZEA), aflatoxin (Aft), ochratoxin A (OTA) were measured in malting barley and malt samples by enzyme immunoassay (E... The levels of five mycotoxins (MT): deoxynivalenol (DON), T-2-toxin (T-2), zearalenone (ZEA), aflatoxin (Aft), ochratoxin A (OTA) were measured in malting barley and malt samples by enzyme immunoassay (ELISA), using test systems RIDASCREEN FAST (R-Biopharm, Germany). 40 samples of malting barley, mainly from the Central part of European Russia and fewer from the Southern part of, and also some samples from Altai (Asian Russia) were analyzed during 2007-2011 years as well as 120 samples of malt from Russian malting companies. It was found that 17% of barley samples were contaminated with MT; in two cases (5%), the MT concentration exceeded maximum allowable levels (MAL). Among malt samples in more than half (in 56%) MT were detected, in 9% of samples, the MT concentration exceeded MAL (Aft-3 incidents, T-2-3 incidents, OTA-2 incidents, ZEA-1 incident). Maximum levels ofmycotoxins in malt were found to be higher than those in barley. These facts support the idea about risky conditions during malting processing. 展开更多
关键词 BARLEY MALT MALTING field fungi Fusarium storage fungi Penicillium and Aspergillus mycotoxins
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The Trace Element Content Observed in the Elderly People of Russia's North Regions
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作者 Lugovaya Elena Maximov Arkadiy Stepanova Evgenia 《Journal of Life Sciences》 2013年第6期663-667,共5页
To investigate the status of mineral metabolism in people residing in huge regional centers of north-western and north-eastern parts of Russia by AES-IBP (atom-emission spectrometry with inductively bonded argon pla... To investigate the status of mineral metabolism in people residing in huge regional centers of north-western and north-eastern parts of Russia by AES-IBP (atom-emission spectrometry with inductively bonded argon plasma), the content of 25 elements in hair samples of surveyed people was examined. The results of the study carried out in Russia's north could testify to significant deformation found in the elderly people bodies' element profiles. The pronounced deficit in such essential elements as Ca, Cr, Mg can be considered the common north-related profile typical for the elderly people from European and Asian north. In addition, age-related formation of all the elements' deficit due to their risen spending at pathologies as well as the increased need in such elements as Zn, Se, Cr, Cu, Mn. The age-related excess of arsenic proved to be typical for Magadan residents. In Anadyr, the age-related excess of lead was found, in Petrozavodsk mercury, and in Arkhangelsk--boron and aluminium. 展开更多
关键词 Macro- and micro-elements elder people northern regions of Russia.
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Characterization of Soil Clay Minerals of the River Nile Sediments, Sohag Region, Egypt: Decomposition of X-Ray Diffraction Patterns
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作者 Abdelhamid Elshater 《Journal of Earth Science and Engineering》 2013年第1期1-13,共13页
Up till now all the clay mineral studies on the soils of the River Nile flood plain in Egypt could not trace the very rapid mineral change observed in these soils. So, the clay mineralogy of the River Nile flood plain... Up till now all the clay mineral studies on the soils of the River Nile flood plain in Egypt could not trace the very rapid mineral change observed in these soils. So, the clay mineralogy of the River Nile flood plain soils in Sohag region, Egypt, has been studied using the method of numerical analysis of X-ray diffraction recordings (curve decomposition) as a new, powerful tool for precise mineral identification. The X-ray patterns of the studied soil clay fraction show that 2:1 clay minerals are much more abundant than kaolinite and that this clay fraction contains fair amounts of K-feldspar and quartz. XRD pattems obtained on the 〈 2 μm fraction of the River Nile sediments indicate the presence of smectite, mixed-layer illite-expanding minerals, kaolinite, mica-illite and chlorite. The decomposed XRD patterns reveal significant changes in the mineralogy of the clays. The major clay phases present in the 4-11 20 range are well crystallized illite (10 A), poorly crystallized illite (10.2-10.4 A), two mixed-layer I-S (illite/smectite) minerals, one with a peak near 13.5 A (rich-smectite) and the other near 11 A (rich-illite). 展开更多
关键词 Clay minerals SOIL River Nile ILLITE SMECTITE mixed-layers.
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Microwave Digestion Sample Hydride Generation-Atomic Fluorescence Spectrometry Determines Trace Selenium of Mogroside
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作者 Xiujing Zhang 《International Journal of Technology Management》 2013年第7期128-130,共3页
0.2000g mogroside sample is digested by 7.0ml nitric acid and 3.0ml hydrogen peroxide, and generated by coprecipitation enrichment hydride - atomic fluorescence spectrometry determines trace selenium in it. Under opti... 0.2000g mogroside sample is digested by 7.0ml nitric acid and 3.0ml hydrogen peroxide, and generated by coprecipitation enrichment hydride - atomic fluorescence spectrometry determines trace selenium in it. Under optimum experiment conditions, a standard curve was produced using selenium standard solution, the linear equation is Ise=2890.6c+0.0012,compared wish the linear relaticnship is not by coprecipitation direct determination of standard series Ise=82.56c+0.0018 Selenium detection sensitivity was increased by 35.01 times,the correlation coefficient of obtained linear regression equation is 0.9996, the detection limit is 0.0012~tg/L and the relative standard deviation is 0.76% (n=5). Containing 0.1808pg.g-1 Se Luo Han Shen samples. Based on mogroside sample, add a certain of standard solution to do recovery experiment, the obtained recovery rate is in 95.8%-103.6% and the result is satisfactory. 展开更多
关键词 Hydride Generation-Atomic Fluorescence Spectrometry MOGROSIDE SELENIUM
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李卓吾批评《水浒传》容兴堂本 被引量:1
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作者 罗原觉 《广州文博》 2013年第1期137-166,共30页
本文是罗原觉先生晚年的一篇未刊稿,今征得罗先生后人的同意,由广州博物馆程存洁、宋平校对,特刊于《广州文博》。为方便读者阅读,除将文稿繁体字改用简体字、竖排版改为横排版外,谨保存,文稿原貌,以资纪念。
关键词 特刊 文稿 原貌 堂本 广州 罗原 繁体字
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汉任城武氏墓前石室测议
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作者 罗原觉 罗思穆 罗德慈 《广州文博》 2012年第1期15-54,共40页
罗原觉先生(1891-1965年),原名罗泽堂,别字韬元、弢盒、恽卢等,号“道在瓦斋”、“菜园病叟”、“平宁瓷佛庵”等,广东南海人,著名文物鉴藏家兼学者。1928年,受聘为广州市市立博物院筹备委员会委员之一,是广州博物馆的创始人之一。1945... 罗原觉先生(1891-1965年),原名罗泽堂,别字韬元、弢盒、恽卢等,号“道在瓦斋”、“菜园病叟”、“平宁瓷佛庵”等,广东南海人,著名文物鉴藏家兼学者。1928年,受聘为广州市市立博物院筹备委员会委员之一,是广州博物馆的创始人之一。1945年,被聘为广东省文献馆文物鉴定顾问。罗原觉收藏宏富,精鉴赏。他生前身后,多将藏品捐赠国家,广州博物馆即其捐赠受益者之一。本文是罗原觉先生晚年在香港完成的一篇力作,2005年由其子女罗思穆先生和罗德慈女士收集整理。今由广州博物馆程存洁、宋平、陈鸿钧编辑校对,并征得作者后人的同意,特刊于《广州文博》,以资纪念。为方便读者阅读,除将文稿繁体字改用简体字外,谨保存文稿原貌。 展开更多
关键词 文稿 测议 收集整理 先生 广州 罗原 繁体字 后人
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Primary sclerosing cholangitis and the risk of colon neoplasia in patients with Crohn’s colitis
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作者 Udayakumar Navaneethan Tarun Rai +1 位作者 Preethi GK Venkatesh Ravi P Kiran 《Gastroenterology Report》 SCIE EI 2016年第3期226-231,I0002,共7页
Background and aim:Crohn’s colitis(CC)is associated with primary sclerosing cholangitis(PSC).However the risk of colon cancer or dysplasia in CC and PSC is unclear.Our aim was to study the risk of colon neoplasia in ... Background and aim:Crohn’s colitis(CC)is associated with primary sclerosing cholangitis(PSC).However the risk of colon cancer or dysplasia in CC and PSC is unclear.Our aim was to study the risk of colon neoplasia in CC in patients with and without PSC.Methods:This is a nested,case-control cohort study of all patients diagnosed with concurrent CC and PSC,seen at the Cleveland Clinic between 1985 and 2012.Forty-three patients with both CC and PSC were compared with a random sample of 159 CC controls without PSC during the same period.Results:Seven(16.3%)of 43 CC patients with PSC developed colon cancer or dysplasia,compared with 22(13.8%)of 159 controls(P=0.98).Of seven colon neoplasia cases in the PSC group,100%occurred proximal to the splenic flexure,compared with 50%(11/22)cases of colon neoplasia in controls occurring in the proximal colon(P=0.001).Based on Cox regression analysis,male gender independently increased the risk of neoplasia[hazard ratio(HR)=2.68;95%confidence interval(CI)1.30-5.54;P=0.008],as did age at CC diagnosis(HR=1.29;95%CI 1.14-1.47;P<0.001),while the use of azathioprine/6-mercaptopurine was protective(HR=0.30;95%CI 0.13-0.70;P=0.005).The presence of PSC did not increase the risk for colon neoplasia(HR=0.45;95%CI 0.18-1.13;P=0.09).Conclusions:CC patients with PSC appear not to be at increased risk of developing colon neoplasia.Among patients in our cohort with colon neoplasia and concurrent PSC,the neoplasia occurred in the proximal colon in all cases. 展开更多
关键词 Crohn’s colitis primary sclerosing cholangitis colon neoplasia
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A stress-rifting origin of Grand Canyon
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作者 Chunan Tang Chunyan Bao +1 位作者 Sanzhong Li Kaiwen Xia 《Science Bulletin》 SCIE EI CAS CSCD 2016年第6期495-504,共10页
The Grand Canyon is a massive rift in the Colorado Plateau. How and when it developed has been debated for nearly 150 years. Most geologists believe the unusual landscape was primarily shaped by water erosion.Here we ... The Grand Canyon is a massive rift in the Colorado Plateau. How and when it developed has been debated for nearly 150 years. Most geologists believe the unusual landscape was primarily shaped by water erosion.Here we propose a stress-rifting model to provide an alternative explanation for the origin of Grand Canyon.This paper adopts a brittle–ductile double layer model to simulate the deformation and rifting of the plateau due to the mantle-melting-induced expansion. Our results show that the uplift induced by thermal expansion and its associated horizontal extension can cause open fractures that extend from the brittle surface to the underlying ductile layer in a top-down way. In addition, we find that episodic uplift can deepen and connect multiple fractures together to form a larger fracture network. Our findings suggest that the formation of the Grand Canyon might have been driven by plateau uplift and its associated rifting under crustal extension, wherein water erosion played only a minor role in shaping the course of the Colorado River. The new paradigm provides simpler explanations to some of the long-standing geological mysteries surrounding the canyon. 展开更多
关键词 UPLIFT RIFT Water erosion Thermal expansion CANYON
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New ommatids from the Late Jurassic of western Liaoning, China (Coleoptera: Archostemata) 被引量:8
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作者 JING-JINGTAN DONGREN MINGLIU 《Insect Science》 SCIE CAS CSCD 2005年第3期207-216,共10页
A new genus Amblomma gen. nov. of fossil beetles is erected and can be assignedto the family Ommatidae because its two procoxal cavities are contiguous and the articulations of the abdominal ventrites are abutting. Th... A new genus Amblomma gen. nov. of fossil beetles is erected and can be assignedto the family Ommatidae because its two procoxal cavities are contiguous and the articulations of the abdominal ventrites are abutting. The new genus is similar to Zygadenia Handlirsch, 1906 (=Notocupes Ponomarenko, 1964), Tetraphalerus Waterhouse, 1901,Rhobdocupes Ponomarenko, 1966 and Sinocupes Lin, 1976, but can be distinguished from other genera according to the following characters: the second segment of antennae is shorterthan the third one in length; the posterior tarsi with the basal segment is obviously shorter than the three following taken together in length; the antennae reach the posterior ridge of prothroax in length, and the sides of the prothroax with serrulate margin. Four new species of the new genus are described and figured: Amblomma psilata gen. et sp. nov., Amblomma rudis gen. et sp. nov., Amblomma epicharis gen. et sp. nov., and Amblomma stabilis gen. etsp. nov. A key to species within this new genus is provided. All the specimens are collected from the Late Jurassic Yixian Formation of western Liaoning and are now housed in the College of Life Science, Capital Normal University, Beijing, China. 展开更多
关键词 ommatidae cupedidae new genus new species JURASSIC yixian formation
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Nomogram to predict primary non-response to infliximab in patients with Crohn’s disease:a multicenter study 被引量:2
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作者 Xiao-Qi Ye Jing Cai +11 位作者 Qiao Yu Xiao-Cang Cao Yan Chen Mei-Xin Rao Bai-Li Chen Yao He Zhi-Rong Zeng Hao Chen Yi-Mou Lin Qian Cao Min-Hu Chen Sheng-Hong Zhang 《Gastroenterology Report》 SCIE EI 2021年第4期329-338,I0002,共11页
Background:Infliximab(IFX)is effective at inducing and maintaining clinical remission and mucosal healing in patients with Crohn’s disease(CD);however,9%–40%of patients do not respond to primary IFX treatment.This s... Background:Infliximab(IFX)is effective at inducing and maintaining clinical remission and mucosal healing in patients with Crohn’s disease(CD);however,9%–40%of patients do not respond to primary IFX treatment.This study aimed to construct and validate nomograms to predict IFX response in CD patients.Methods:A total of 343 patients diagnosed with CD who had received IFX induction from four tertiary centers between September 2008 and September 2019 were enrolled in this study and randomly classified into a training cohort(n=240)and a validation cohort(n=103).The primary outcome was primary non-response(PNR)and the secondary outcome was mucosal healing(MH).Nomograms were constructed from the training cohort using multivariate logistic regression.Performance of nomograms was evaluated by area under the receiver-operating characteristic curve(AUC)and calibration curve.The clinical usefulness of nomograms was evaluated by decision-curve analysis.Results:The nomogram for PNR was developed based on four independent predictors:age,C-reactive protein(CRP)at week 2,body mass index,and non-stricturing,non-penetrating behavior(B1).AUC was 0.77 in the training cohort and 0.76 in the validation cohort.The nomogram for MH included four independent factors:baseline Crohn’s Disease Endoscopic Index of Severity,CRP at week 2,B1,and disease duration.AUC was 0.79 and 0.72 in the training and validation cohorts,respectively.The two nomograms showed good calibration in both cohorts and were superior to single factors and an existing matrix model.The decision curve indicated the clinical usefulness of the PNR nomogram.Conclusions:We established and validated nomograms for the prediction of PNR to IFX and MH in CD patients.This graphical tool is easy to use and will assist physicians in therapeutic decision-making. 展开更多
关键词 Crohn’s disease INFLIXIMAB NOMOGRAM primary non-response mucosal healing
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