Selective cyclo-oxygenase-2 (CQX-2) inhibitor, VIOXX (rofecoxib), wasvoluntarily withdrawn worldwide from drugstores by its maker Merck & Co., Inc. on September 30,2004, for its potential lethal side effects of he...Selective cyclo-oxygenase-2 (CQX-2) inhibitor, VIOXX (rofecoxib), wasvoluntarily withdrawn worldwide from drugstores by its maker Merck & Co., Inc. on September 30,2004, for its potential lethal side effects of heart attack or stroke, The Merck' s decision wasbased on new, three-year data from a prospective, multi-center, randomized, placebo-controlled,double-blind clinical trial of VIOXX with an unrelated study, the APPROVe (Adenomatous PolypPrevention on VIOXX) trial. The trial has been enrolling 2 600 patients and comparing 156 weeks(three years) of treatment with VIOXX 25 mg to placebo since 2000.展开更多
Concentrations of rare earth elements (REE) in Jurassic coal of YanAn Formation from Dongsheng coalfield located in the northeast of Ordos basin were determined by instrumental neutron activation analysis (INAA). Curv...Concentrations of rare earth elements (REE) in Jurassic coal of YanAn Formation from Dongsheng coalfield located in the northeast of Ordos basin were determined by instrumental neutron activation analysis (INAA). Curves of distribution pattern of REE were drawn, and many geochemical parameters were calculated. The result shows that 1) The contents of REE in Jurassic coal with low ash and sulfur are lower than those of Carboniferous and Permian coal from the Basin of North China; 2) Inside the Dongsheng coalfield, coal from the north has higher contents of REE than that form the south because the north is near the area of source rock which is the main supplier of REE, while the south is far away from the area of source rocks; 3) Although Jurassic coal in Dongsheng is the low ash coal with less than 10%, the contents of REE are still proportional to ash yield of ash and SiO 2 contents. 4) Although the Jurassic coal in Dongsheng were deposited in oxidative continental environment of river lake, Eu depletion of REE in coal commonly exists, and positive abnormity of Ce dose not exist. This reflects the REE distribution pattern of REE in source rock of continental area; and 5) Compared with other rocks, coal shows extremely complexity of distribution pattern of REE, which is the result of continuous alteration and redistribution of matter in coal occurred in open basin system.展开更多
文摘Selective cyclo-oxygenase-2 (CQX-2) inhibitor, VIOXX (rofecoxib), wasvoluntarily withdrawn worldwide from drugstores by its maker Merck & Co., Inc. on September 30,2004, for its potential lethal side effects of heart attack or stroke, The Merck' s decision wasbased on new, three-year data from a prospective, multi-center, randomized, placebo-controlled,double-blind clinical trial of VIOXX with an unrelated study, the APPROVe (Adenomatous PolypPrevention on VIOXX) trial. The trial has been enrolling 2 600 patients and comparing 156 weeks(three years) of treatment with VIOXX 25 mg to placebo since 2000.
文摘Concentrations of rare earth elements (REE) in Jurassic coal of YanAn Formation from Dongsheng coalfield located in the northeast of Ordos basin were determined by instrumental neutron activation analysis (INAA). Curves of distribution pattern of REE were drawn, and many geochemical parameters were calculated. The result shows that 1) The contents of REE in Jurassic coal with low ash and sulfur are lower than those of Carboniferous and Permian coal from the Basin of North China; 2) Inside the Dongsheng coalfield, coal from the north has higher contents of REE than that form the south because the north is near the area of source rock which is the main supplier of REE, while the south is far away from the area of source rocks; 3) Although Jurassic coal in Dongsheng is the low ash coal with less than 10%, the contents of REE are still proportional to ash yield of ash and SiO 2 contents. 4) Although the Jurassic coal in Dongsheng were deposited in oxidative continental environment of river lake, Eu depletion of REE in coal commonly exists, and positive abnormity of Ce dose not exist. This reflects the REE distribution pattern of REE in source rock of continental area; and 5) Compared with other rocks, coal shows extremely complexity of distribution pattern of REE, which is the result of continuous alteration and redistribution of matter in coal occurred in open basin system.
