The former gas pipeline operating pressure transmission determined mostly according to the determined formula into the corresponding pipeline parameters are obtained, and the parameters of the actual pipeline due to m...The former gas pipeline operating pressure transmission determined mostly according to the determined formula into the corresponding pipeline parameters are obtained, and the parameters of the actual pipeline due to many reasons, such as measurement error, production batch, etc., is not a fixed value. This paper on pipeline integrity established limit state equation, using Monte Carlo method to calculate the gas pipeline in different pressures of reliability, according to the API （American Petroleum Institute） 579 recommended target reliability to determine the operating pressure of the different regions, and design coefficient method, the calculated results are compared, results of calculation reliability is more reasonable and improve the delivery pressure of the area, the pipeline safety management provides the basis.展开更多
The fat nano-emulsion, which has been used as a drug carrier, especially for the poorly water soluble drug, has drawn favorable attention recently. Ubenimex is a poorly soluble drug with no parenteral treatment availa...The fat nano-emulsion, which has been used as a drug carrier, especially for the poorly water soluble drug, has drawn favorable attention recently. Ubenimex is a poorly soluble drug with no parenteral treatment available for patients. This study was aimed at the manufacture of a ubenimex loaded fat nano-emulsion for intravenous delivery by SolEmuls~ technology. The formulation and the process parameters were optimized by single-factor design and the obtained ubenimex loaded fat nano-emulsion was stable even after autoclaving. The average particle size was near 200 nm with narrow size distribution and a negative zeta potential of -44 mV. The in vitro release behavior of ubenimex from the fat nano-emulsion could be described by the double phase kinetics model and expressed by the following equation： 100 - Q = 75.27e^-0.369t ＋ 15.94e^-0.0324t, Rα = 0.9863, Rβ = 0.9878. The pharmacokinetic study showed that the pharmacokinetic curves of both the ubenimex fat nano-emulsion and the i.v. ubenimex suspension, were similar and the main parameters showed no significant difference except t1/2. In conclusion, the fat nano-emulsion with ubenimex has potential as a safe and effective parenteral delivery system for poorly water soluble anti-cancer drugs.展开更多
文摘The former gas pipeline operating pressure transmission determined mostly according to the determined formula into the corresponding pipeline parameters are obtained, and the parameters of the actual pipeline due to many reasons, such as measurement error, production batch, etc., is not a fixed value. This paper on pipeline integrity established limit state equation, using Monte Carlo method to calculate the gas pipeline in different pressures of reliability, according to the API （American Petroleum Institute） 579 recommended target reliability to determine the operating pressure of the different regions, and design coefficient method, the calculated results are compared, results of calculation reliability is more reasonable and improve the delivery pressure of the area, the pipeline safety management provides the basis.
基金Shandong Province Natural Science Foundation (Grant No.ZR2009CM011)
文摘The fat nano-emulsion, which has been used as a drug carrier, especially for the poorly water soluble drug, has drawn favorable attention recently. Ubenimex is a poorly soluble drug with no parenteral treatment available for patients. This study was aimed at the manufacture of a ubenimex loaded fat nano-emulsion for intravenous delivery by SolEmuls~ technology. The formulation and the process parameters were optimized by single-factor design and the obtained ubenimex loaded fat nano-emulsion was stable even after autoclaving. The average particle size was near 200 nm with narrow size distribution and a negative zeta potential of -44 mV. The in vitro release behavior of ubenimex from the fat nano-emulsion could be described by the double phase kinetics model and expressed by the following equation： 100 - Q = 75.27e^-0.369t ＋ 15.94e^-0.0324t, Rα = 0.9863, Rβ = 0.9878. The pharmacokinetic study showed that the pharmacokinetic curves of both the ubenimex fat nano-emulsion and the i.v. ubenimex suspension, were similar and the main parameters showed no significant difference except t1/2. In conclusion, the fat nano-emulsion with ubenimex has potential as a safe and effective parenteral delivery system for poorly water soluble anti-cancer drugs.
