Research of competitiveness of China and the United States is of great significance to enhancing China＇s economic competitiveness and achieving the objective of national rejuvenation. By creating a competitiveness fr...Research of competitiveness of China and the United States is of great significance to enhancing China＇s economic competitiveness and achieving the objective of national rejuvenation. By creating a competitiveness framework and a system of heterogeneous indicators, this paper investigates the competitiveness of China and the US in terms of current status, historic change and global environment. Our research led to the following findings： core factors determine the level of competitiveness for China and the US; the national competitiveness of both countries is evolving towards structural homogeneity; and China and the US lead most countries in many common areas. China has the potential to overtake the US in competitiveness in the future. We suggest that China increase its competitiveness by promoting its advantages, addressing its weaknesses and focusing on core areas.展开更多
The duck circovirus （DuCV） infection in sick ducks from Fujian Province was investigated. The liver samples of 43 sick Muscovy ducks with infectious serositis were collected from 12 duck farms in Fujian Province Bas...The duck circovirus （DuCV） infection in sick ducks from Fujian Province was investigated. The liver samples of 43 sick Muscovy ducks with infectious serositis were collected from 12 duck farms in Fujian Province Based on the published sequences of DuCV, two primers were designed for the detection of DuCV and four pairs of primers were designed to amplify four overlapping fragments that cover the complete genome of DuCV. The specific PCR products were amplified from positive samples. The fragments were then cloned into pMD18-T vector and sequenced, and the full length genomic sequence of the FJ0601 isolate of DuCV was obtained. PCR analysis showed that the proportion of ducks which were positive for circovirus was 79% and 10 out of the 12 farms were positive. Sequence analysis showed that the complete genome of DuCV-FJ0601 was 1988 bp and possessed features common to the family Circoviridae which included a stem-loop structure and the Rep protein motifs. Homology analysis showed that FJ0601 isolate of DuCV had 97.3%-97.5% nucleotide sequence identity to all the four Taiwan isolates （TC1/2002, TC2/2002, TC3/2002, TC4/2002）, 82.9% identity to the America （33753-52） isolate and 82.3% identity to the Germany isolate. Phylogenetic analysis with Clustal W, however, showed that FJ0601 isolate of DuCV was on a common branch with Taiwan isolates, and Germany and America isolates belonged to the other branch.展开更多
The spectacular scenery of Glacier National Park is the result of glacial erosion as well as post-glacial mass wasting processes. Debris flow magnitude and frequency have been established through extensive fieldwork a...The spectacular scenery of Glacier National Park is the result of glacial erosion as well as post-glacial mass wasting processes. Debris flow magnitude and frequency have been established through extensive fieldwork across seven separate drainage basins in the eastern portion of the park. This paper summarizes the investigation of the hypotheses that debris flow distribution in the Glacier National Park, east of the Continental Divide is （a） not random; and Co） concentrated adjacent to the Continental Divide. The location of 2317 debris flows were identified and mapped from sixty-three 1-m resolution Digital Orthophoto Quarter Quadrangles and their spatial distribution was then analyzed using ArcView Spatial Analyst GIS software. The GIS analysis showed that the debris flows are not randomly distributed nor are they concentrated directly adjacent to the Divide. While the Continental Divide provides orographic enhancement of precipitation directly adjacent to the Divide, the debris flows are not concentrated there due to a lack of available weathered regolith. The most recent Little Ice Age glaciation removed the debris directly adjacent to the Divide, and without an adequate debris supply, these steep slopes experience few debris flows. Both abundant water and an adequate debris supply are necessary to initiate slope failure, resulting in a clustering of debris flows at the break in slope where valley walls contact talus slopes. A variety of summer storm and antecedent moisture conditions initiate slope failures in the Glacier National Park, with no distinct meteorological threshold. With over two million visitorsevery year, and millions of dollars of park infrastructure at risk, identifying the hazard of debris flows is essential to future park management plans.展开更多
AIM To investigate the impact of IL28 B and OAS gene polymorphisms on interferon treatment responses in children with chronic hepatitis B.METHODS We enrolled 52 children(between the ages of 4 and 18) with hepatitis B ...AIM To investigate the impact of IL28 B and OAS gene polymorphisms on interferon treatment responses in children with chronic hepatitis B.METHODS We enrolled 52 children(between the ages of 4 and 18) with hepatitis B e antigen-negative chronic hepatitis B(CHB), who were treated with pegylated interferon alfa for 48 wk. Single nucleotide polymorphisms in the OAS1(rs1131476), OAS2(rs1293747),OAS3(rs2072136), OASL(rs10849829) and IL28B(rs12979860, rs12980275 and rs8099917) genes were studied to examine their associations with responses to IFN treatment in paediatric patients. We adopted two criteria for the therapeutic response, achieving an hepatitis B virus(HBV) DNA level < 2000 IU/m L and normalization of ALT activity(< 40 IU/L). To perform the analyses, we compared the patients in terms of achieving a partial response(PR) and a complete response(CR) upon measurement at the 24-wk posttreatment follow-up. RESULTS The PR and CR rates were 80.8% and 42.3%, respectively. Factors such as age, gender and liver histology had no impact on the type of response(partial or complete). A statistically significant relationship between higher baseline HBV DNA and ALT activity levels and lower rates of PR and CR was shown(P < 0.05). The allele association analysis revealed that only the IL-28 B rs12979860(C vs T) and IL28 B rs12980275(A vs G) markers significantly affected the achievement of PR(P = 0.021, OR = 3.3, 95%CI: 1.2-9.2 and P = 0.014, OR = 3.7, 95%CI: 1.3-10.1, respectively). However, in the genotype analysis, only IL-28 B rs12980275 was significantly associated with PR(AA vs AG-GG, P = 0.014, OR = 10.9, 95%CI: 1.3-93.9). The association analysis for CR showed that the TT genotype of IL28 B rs12979860 was present only in the no-CR group(P = 0.033) and the AA genotype of OASL rs10849829 was significantly more frequent in the noCR group(P = 0.044, OR = 0.26, 95%CI: 0.07-0.88). The haplotype analysis revealed significant associations between PR and CR and OAS haplotype(P = 0.0002 and P = 0.001, respectively), but no association with IL28 B haplotype was observed.CONCLUSION IL28 B and OAS polymorphisms are associated with different clinical outcomes in CHB children treated with interferon.展开更多
In this study,the authors evaluated two re-motely sensed surface soil moisture datasets derived from the Advanced Microwave Scanning Radiometer of the Earth Observing System (AMSR-E) over northern China.The soil moist...In this study,the authors evaluated two re-motely sensed surface soil moisture datasets derived from the Advanced Microwave Scanning Radiometer of the Earth Observing System (AMSR-E) over northern China.The soil moisture datasets were derived from algorithms developed by the National Snow and Ice Data Center (NSIDC) and jointly developed by the Vrije Universiteit Amsterdam and NASA Goddard Space Flight Center (VUA-NASA).The NSIDC and VUA-NASA products were compared to in situ soil moisture data from nine enhanced coordinated observation stations.The VUA-NASA dataset presented a strong correlation with top layer in situ soil moisture observations,and the correla-tion coefficients ranged from 0.34 to 0.73 (p<0.01).The correlation coefficients decreased as the observed soil layer depth increased.The correlation coefficients be-tween the NSIDC retrievals and the top layer in situ ob-servations were between 0.10 and 0.62 (p<0.01).Fur-thermore,VUA-NASA soil moisture variations agreed well with in situ soil moisture dynamics and responded sensitively to precipitation events.In contrast,the NSIDC dataset failed to capture signals of soil moisture dynamics.The analyses demonstrated that the VUA-NASA product was capable of representing soil moisture conditions over northern China.展开更多
Negative skin friction (NSF) is one of the important problems when designing a pile foundation. However, the influence of loading sequence on the dragload and downdrag for pile foundation is seldom studied. In this pa...Negative skin friction (NSF) is one of the important problems when designing a pile foundation. However, the influence of loading sequence on the dragload and downdrag for pile foundation is seldom studied. In this paper, a three-dimensional numerical model was established using FLAC3D. Compared with the results of model test, the established model could be used to study the NSF of pile foundation. The influencing factors were discussed including the length-diameter ratio of pile and the loading sequence of pile head load and surcharge. A case history was analyzed using FLAC3D. The calculated results are in good agreement with the measured results. It is concluded that the dragload and downdrag are remarkably influenced by the loading sequence of pile head load and surcharge. The dragload and downdrag reach the maximum values under the condition of surcharge after pile head load.展开更多
文摘Research of competitiveness of China and the United States is of great significance to enhancing China＇s economic competitiveness and achieving the objective of national rejuvenation. By creating a competitiveness framework and a system of heterogeneous indicators, this paper investigates the competitiveness of China and the US in terms of current status, historic change and global environment. Our research led to the following findings： core factors determine the level of competitiveness for China and the US; the national competitiveness of both countries is evolving towards structural homogeneity; and China and the US lead most countries in many common areas. China has the potential to overtake the US in competitiveness in the future. We suggest that China increase its competitiveness by promoting its advantages, addressing its weaknesses and focusing on core areas.
基金Shandong Provincial Excellent YoungScientist Fund (2004BS06002)Innovation Fund ofShandong Agricultural University
文摘The duck circovirus （DuCV） infection in sick ducks from Fujian Province was investigated. The liver samples of 43 sick Muscovy ducks with infectious serositis were collected from 12 duck farms in Fujian Province Based on the published sequences of DuCV, two primers were designed for the detection of DuCV and four pairs of primers were designed to amplify four overlapping fragments that cover the complete genome of DuCV. The specific PCR products were amplified from positive samples. The fragments were then cloned into pMD18-T vector and sequenced, and the full length genomic sequence of the FJ0601 isolate of DuCV was obtained. PCR analysis showed that the proportion of ducks which were positive for circovirus was 79% and 10 out of the 12 farms were positive. Sequence analysis showed that the complete genome of DuCV-FJ0601 was 1988 bp and possessed features common to the family Circoviridae which included a stem-loop structure and the Rep protein motifs. Homology analysis showed that FJ0601 isolate of DuCV had 97.3%-97.5% nucleotide sequence identity to all the four Taiwan isolates （TC1/2002, TC2/2002, TC3/2002, TC4/2002）, 82.9% identity to the America （33753-52） isolate and 82.3% identity to the Germany isolate. Phylogenetic analysis with Clustal W, however, showed that FJ0601 isolate of DuCV was on a common branch with Taiwan isolates, and Germany and America isolates belonged to the other branch.
基金This research was partially by a Minnesota State University-Mankato Faculty Research Grant
文摘The spectacular scenery of Glacier National Park is the result of glacial erosion as well as post-glacial mass wasting processes. Debris flow magnitude and frequency have been established through extensive fieldwork across seven separate drainage basins in the eastern portion of the park. This paper summarizes the investigation of the hypotheses that debris flow distribution in the Glacier National Park, east of the Continental Divide is （a） not random; and Co） concentrated adjacent to the Continental Divide. The location of 2317 debris flows were identified and mapped from sixty-three 1-m resolution Digital Orthophoto Quarter Quadrangles and their spatial distribution was then analyzed using ArcView Spatial Analyst GIS software. The GIS analysis showed that the debris flows are not randomly distributed nor are they concentrated directly adjacent to the Divide. While the Continental Divide provides orographic enhancement of precipitation directly adjacent to the Divide, the debris flows are not concentrated there due to a lack of available weathered regolith. The most recent Little Ice Age glaciation removed the debris directly adjacent to the Divide, and without an adequate debris supply, these steep slopes experience few debris flows. Both abundant water and an adequate debris supply are necessary to initiate slope failure, resulting in a clustering of debris flows at the break in slope where valley walls contact talus slopes. A variety of summer storm and antecedent moisture conditions initiate slope failures in the Glacier National Park, with no distinct meteorological threshold. With over two million visitorsevery year, and millions of dollars of park infrastructure at risk, identifying the hazard of debris flows is essential to future park management plans.
文摘AIM To investigate the impact of IL28 B and OAS gene polymorphisms on interferon treatment responses in children with chronic hepatitis B.METHODS We enrolled 52 children(between the ages of 4 and 18) with hepatitis B e antigen-negative chronic hepatitis B(CHB), who were treated with pegylated interferon alfa for 48 wk. Single nucleotide polymorphisms in the OAS1(rs1131476), OAS2(rs1293747),OAS3(rs2072136), OASL(rs10849829) and IL28B(rs12979860, rs12980275 and rs8099917) genes were studied to examine their associations with responses to IFN treatment in paediatric patients. We adopted two criteria for the therapeutic response, achieving an hepatitis B virus(HBV) DNA level < 2000 IU/m L and normalization of ALT activity(< 40 IU/L). To perform the analyses, we compared the patients in terms of achieving a partial response(PR) and a complete response(CR) upon measurement at the 24-wk posttreatment follow-up. RESULTS The PR and CR rates were 80.8% and 42.3%, respectively. Factors such as age, gender and liver histology had no impact on the type of response(partial or complete). A statistically significant relationship between higher baseline HBV DNA and ALT activity levels and lower rates of PR and CR was shown(P < 0.05). The allele association analysis revealed that only the IL-28 B rs12979860(C vs T) and IL28 B rs12980275(A vs G) markers significantly affected the achievement of PR(P = 0.021, OR = 3.3, 95%CI: 1.2-9.2 and P = 0.014, OR = 3.7, 95%CI: 1.3-10.1, respectively). However, in the genotype analysis, only IL-28 B rs12980275 was significantly associated with PR(AA vs AG-GG, P = 0.014, OR = 10.9, 95%CI: 1.3-93.9). The association analysis for CR showed that the TT genotype of IL28 B rs12979860 was present only in the no-CR group(P = 0.033) and the AA genotype of OASL rs10849829 was significantly more frequent in the noCR group(P = 0.044, OR = 0.26, 95%CI: 0.07-0.88). The haplotype analysis revealed significant associations between PR and CR and OAS haplotype(P = 0.0002 and P = 0.001, respectively), but no association with IL28 B haplotype was observed.CONCLUSION IL28 B and OAS polymorphisms are associated with different clinical outcomes in CHB children treated with interferon.
基金supported by the National Basic Research Program of China (Grant No.2009CB723904)
文摘In this study,the authors evaluated two re-motely sensed surface soil moisture datasets derived from the Advanced Microwave Scanning Radiometer of the Earth Observing System (AMSR-E) over northern China.The soil moisture datasets were derived from algorithms developed by the National Snow and Ice Data Center (NSIDC) and jointly developed by the Vrije Universiteit Amsterdam and NASA Goddard Space Flight Center (VUA-NASA).The NSIDC and VUA-NASA products were compared to in situ soil moisture data from nine enhanced coordinated observation stations.The VUA-NASA dataset presented a strong correlation with top layer in situ soil moisture observations,and the correla-tion coefficients ranged from 0.34 to 0.73 (p<0.01).The correlation coefficients decreased as the observed soil layer depth increased.The correlation coefficients be-tween the NSIDC retrievals and the top layer in situ ob-servations were between 0.10 and 0.62 (p<0.01).Fur-thermore,VUA-NASA soil moisture variations agreed well with in situ soil moisture dynamics and responded sensitively to precipitation events.In contrast,the NSIDC dataset failed to capture signals of soil moisture dynamics.The analyses demonstrated that the VUA-NASA product was capable of representing soil moisture conditions over northern China.
基金Supported by National Natural Science Foundation of China (No.50679015)China Postdoctoral Science Foundation (No.20090461062)
文摘Negative skin friction (NSF) is one of the important problems when designing a pile foundation. However, the influence of loading sequence on the dragload and downdrag for pile foundation is seldom studied. In this paper, a three-dimensional numerical model was established using FLAC3D. Compared with the results of model test, the established model could be used to study the NSF of pile foundation. The influencing factors were discussed including the length-diameter ratio of pile and the loading sequence of pile head load and surcharge. A case history was analyzed using FLAC3D. The calculated results are in good agreement with the measured results. It is concluded that the dragload and downdrag are remarkably influenced by the loading sequence of pile head load and surcharge. The dragload and downdrag reach the maximum values under the condition of surcharge after pile head load.
