AIM: To investigate the effects of curcumin on gastric microcirculation and inflammation in rats with indo- methacin-induced gastric damage. METHODS: Male Sprague-Dawley rats were randomly divided into three groups....AIM: To investigate the effects of curcumin on gastric microcirculation and inflammation in rats with indo- methacin-induced gastric damage. METHODS: Male Sprague-Dawley rats were randomly divided into three groups. Group 1 (control group, n = 5) was fed with olive oil and 5% NaHCOf (vehicle). Group 2 [indomethacin (IMN) group, n = 5] was fed with olive oil 30 min prior to indomethacin 150 mg/kg body weight (BW) dissolved in 5% NaHCO3- at time 0th and 4th h. Group 3 (INN ± Cur group, n = 4) was fed with curcumin 200 mg/kg BW dissolved in olive oil 0.5 mL, 30 min prior to indomethacin at 0th and 4th h. Leukocyte-endothelium interactions at postcapillary venules were recorded after acridine orange injection. Blood samples were determined for intercellular ad- hesion molecule (ICAM)-1 and tumor necrosis factor (TNF)-a levels using enzyme linked immunosorbent assay method. Finally, the stomach was removed for histopathological examination for gastric lesions and grading for neutrophil infiltration. RESULTS: In group 2, the leukocyte adherence in postcapillary venules was significantly increased com- pared to the control group (6.40±2.30 cells/frame vs 1.20 ± 0.83 cells/frame, P = 0.001). Pretreatment with curcumin caused leukocyte adherence to postcapil- lary venule to decline (3.00±0.81 cells/frame vs 6.40 ± 2.30 cells/frame, P = 0.027). The levels of ICAM-1 and TNF-aincreased significantly in the indomethacin- treated group compared with the control group (1106.50 ± 504.22 pg/mL vs 336.93 a= 224.82 pg/mL, P = 0.011 and 230.92±114.47 pg/mL vs 47.13±65.59 pg/mL, P = 0.009 respectively). Pretreatment with curcumin sig- nificantly decreased the elevation of ICAM-1 and TNF-a levels compared to treatment with indomethacin alone (413.66 ± 147.74 pg/mL vs 1106.50 ± 504.22 pg/mL, P = 0.019 and 58.27 ± 67.74 pg/mL vs 230.92 ± 114.47 pg/mL, P = 0.013 respectively). The histological appear- ance of the stomach in the control group was normal. In the indomethacin-treated group, the stomachs showed a mild to moderate neutrophil infiltration score. Gastric lesions were erosive and ulcerative. In rats treated with indomethacin and curcumin, stomach histopathology improved and showed only a mild neutrophil infiltration score and fewer erosive lesions in the gastric mucosa. CONCLUSION: The results indicate that curcumin pre- vents indomethacin-induced gastropathy through the improvement of gastric microcirculation by attenuating the level of ICAM-1 and TNF-a,展开更多
This study is concerned with the literary and aesthetic influences that led to Charles Sheeler's formation of a paragone in his early 20th century work. This painter, photographer, printmaker, and experimental filmma...This study is concerned with the literary and aesthetic influences that led to Charles Sheeler's formation of a paragone in his early 20th century work. This painter, photographer, printmaker, and experimental filmmaker had very specific ideas concerning the hierarchy of the visual arts. While he is known for embracing a wide range of media and materials, by 1919 his aesthetic thought reveals a desire to elevate the painting over all other media. This formation of a visual paragone was initially influenced by his involvement in the interdisciplinary circles which surrounded both Alfred Stieglitz and Walter and Louise Arensberg in New York City. In particular, his lifelong friendship with the poet and writer William Carlos Williams would shape his aesthetic thought leading to his elevation of painting over all other media. Sheeler's paragone would begin to form during his stays at the rural Doylestown House in Bucks County, Pennsylvania. This rural home, which he first rented with fellow painter Morton Schamberg in 1916, would become an artistic refuge for both artists. While commercial photography was beginning to take up more if his time in Philadelphia, it was the retreats to the Doylestown house that enabled Sheeler to continue experiments in painting and begin to think of the photograph as something other than a document of architectural work. At this early stage in his artistic career, Sheeler was beginning to form his own hierarchy and contribute to the continuing argument of painting versus photography.展开更多
A strong Mw7.0 earthquake struck Pingtung offshore of Talwan on December 26, 2006. It consisted of two major events with an 8-minute interval. The first major shock occurred at 12:26 UTC. Focal mechanism results from...A strong Mw7.0 earthquake struck Pingtung offshore of Talwan on December 26, 2006. It consisted of two major events with an 8-minute interval. The first major shock occurred at 12:26 UTC. Focal mechanism results from Harvard, USGS, and BATS all indicated that the first major shock was a normal fault earthquake and the second one was dominated by strike-slip offsets. The location of the epicenter varied greatly in depth in different analyses. The latest results showed that the focal depth of the first shock was most probably around 40-44 km, placing the epicenter in the lithospheric mantle. However, this is not a location where earthquakes usually occur. To explore the geodynamical mechanism of this event, we carded out 2D finite element method (FEM) numerical experiments. Our primary results indicate that the geodynamical background, as well as the formation of Pingtung earthquake, is a consequence of the collision between Luzon arc and Chinese continental margin. Although Taiwan Island is in the shadow of NW-SE trending compressive collision zone, the existence of ductile lower crust leads to the decoupling between upper crust and lithospheric mantle. As lithospheric mantle subducts to the depth of around 250 km, the upper part of the bending subduction slab puts itself in an extensional state. The extensional stress from bending induced the occurrence of this normal fault earthquake at the critical point.展开更多
基金Supported by The Grant of Ratchadaphiseksomphot,Faculty of Medicine,Chulalongkorn University,Bangkok,Thailand[RA53/52(2)]
文摘AIM: To investigate the effects of curcumin on gastric microcirculation and inflammation in rats with indo- methacin-induced gastric damage. METHODS: Male Sprague-Dawley rats were randomly divided into three groups. Group 1 (control group, n = 5) was fed with olive oil and 5% NaHCOf (vehicle). Group 2 [indomethacin (IMN) group, n = 5] was fed with olive oil 30 min prior to indomethacin 150 mg/kg body weight (BW) dissolved in 5% NaHCO3- at time 0th and 4th h. Group 3 (INN ± Cur group, n = 4) was fed with curcumin 200 mg/kg BW dissolved in olive oil 0.5 mL, 30 min prior to indomethacin at 0th and 4th h. Leukocyte-endothelium interactions at postcapillary venules were recorded after acridine orange injection. Blood samples were determined for intercellular ad- hesion molecule (ICAM)-1 and tumor necrosis factor (TNF)-a levels using enzyme linked immunosorbent assay method. Finally, the stomach was removed for histopathological examination for gastric lesions and grading for neutrophil infiltration. RESULTS: In group 2, the leukocyte adherence in postcapillary venules was significantly increased com- pared to the control group (6.40±2.30 cells/frame vs 1.20 ± 0.83 cells/frame, P = 0.001). Pretreatment with curcumin caused leukocyte adherence to postcapil- lary venule to decline (3.00±0.81 cells/frame vs 6.40 ± 2.30 cells/frame, P = 0.027). The levels of ICAM-1 and TNF-aincreased significantly in the indomethacin- treated group compared with the control group (1106.50 ± 504.22 pg/mL vs 336.93 a= 224.82 pg/mL, P = 0.011 and 230.92±114.47 pg/mL vs 47.13±65.59 pg/mL, P = 0.009 respectively). Pretreatment with curcumin sig- nificantly decreased the elevation of ICAM-1 and TNF-a levels compared to treatment with indomethacin alone (413.66 ± 147.74 pg/mL vs 1106.50 ± 504.22 pg/mL, P = 0.019 and 58.27 ± 67.74 pg/mL vs 230.92 ± 114.47 pg/mL, P = 0.013 respectively). The histological appear- ance of the stomach in the control group was normal. In the indomethacin-treated group, the stomachs showed a mild to moderate neutrophil infiltration score. Gastric lesions were erosive and ulcerative. In rats treated with indomethacin and curcumin, stomach histopathology improved and showed only a mild neutrophil infiltration score and fewer erosive lesions in the gastric mucosa. CONCLUSION: The results indicate that curcumin pre- vents indomethacin-induced gastropathy through the improvement of gastric microcirculation by attenuating the level of ICAM-1 and TNF-a,
文摘This study is concerned with the literary and aesthetic influences that led to Charles Sheeler's formation of a paragone in his early 20th century work. This painter, photographer, printmaker, and experimental filmmaker had very specific ideas concerning the hierarchy of the visual arts. While he is known for embracing a wide range of media and materials, by 1919 his aesthetic thought reveals a desire to elevate the painting over all other media. This formation of a visual paragone was initially influenced by his involvement in the interdisciplinary circles which surrounded both Alfred Stieglitz and Walter and Louise Arensberg in New York City. In particular, his lifelong friendship with the poet and writer William Carlos Williams would shape his aesthetic thought leading to his elevation of painting over all other media. Sheeler's paragone would begin to form during his stays at the rural Doylestown House in Bucks County, Pennsylvania. This rural home, which he first rented with fellow painter Morton Schamberg in 1916, would become an artistic refuge for both artists. While commercial photography was beginning to take up more if his time in Philadelphia, it was the retreats to the Doylestown house that enabled Sheeler to continue experiments in painting and begin to think of the photograph as something other than a document of architectural work. At this early stage in his artistic career, Sheeler was beginning to form his own hierarchy and contribute to the continuing argument of painting versus photography.
基金supported by National Natural Science Foundation of China (Grant No. 40774048)Major Research of National Natural Science Foundation of China (Grant No. 90814014)Sino-Probe Project of China and Knowledge Innovation Program of Chinese Academy of Sciences (Grant No. KZCX2-YW-123)
文摘A strong Mw7.0 earthquake struck Pingtung offshore of Talwan on December 26, 2006. It consisted of two major events with an 8-minute interval. The first major shock occurred at 12:26 UTC. Focal mechanism results from Harvard, USGS, and BATS all indicated that the first major shock was a normal fault earthquake and the second one was dominated by strike-slip offsets. The location of the epicenter varied greatly in depth in different analyses. The latest results showed that the focal depth of the first shock was most probably around 40-44 km, placing the epicenter in the lithospheric mantle. However, this is not a location where earthquakes usually occur. To explore the geodynamical mechanism of this event, we carded out 2D finite element method (FEM) numerical experiments. Our primary results indicate that the geodynamical background, as well as the formation of Pingtung earthquake, is a consequence of the collision between Luzon arc and Chinese continental margin. Although Taiwan Island is in the shadow of NW-SE trending compressive collision zone, the existence of ductile lower crust leads to the decoupling between upper crust and lithospheric mantle. As lithospheric mantle subducts to the depth of around 250 km, the upper part of the bending subduction slab puts itself in an extensional state. The extensional stress from bending induced the occurrence of this normal fault earthquake at the critical point.