根据世界卫生组织从巴西国家控制规划获得的信息得知,美洲锥虫病(Chagao Disease)的传播基本上已消除。此重大成就乃是由于根据“南美国家行动”(Initiatine of the Southern ConeCountries)而采取控制措施的结果,预计将于1998年组织独...根据世界卫生组织从巴西国家控制规划获得的信息得知,美洲锥虫病(Chagao Disease)的传播基本上已消除。此重大成就乃是由于根据“南美国家行动”(Initiatine of the Southern ConeCountries)而采取控制措施的结果,预计将于1998年组织独立的考察组对阻断锥虫病媒介和输液传播的成果进行验收。巴西是美洲锥虫病的最大流行国,其患病数占锥虫总发病数的40％以上。 在1970年,最早锥虫流行地区占巴西国土的36％以上。展开更多
Pemphigus foliaceus (PF) and the endemic form Fogo Selvagem(FS)are mediated by pathogenic antibodies to the EC1-2 domains of desmoglein-1. There is a preclinical phase with antibodies to only EC5. Based on geographic ...Pemphigus foliaceus (PF) and the endemic form Fogo Selvagem(FS)are mediated by pathogenic antibodies to the EC1-2 domains of desmoglein-1. There is a preclinical phase with antibodies to only EC5. Based on geographic clustering of cases, FS is thought to have an, as yet unidentified, environmental trigger. In this study we have searched for anti-desmoglein-1 antibodies in sera from parasitic (leishmaniasis, Chagas, and onchocerciasis), and infectious diseases (leprosy and South American (SA) blastomycosis), which are prevalent in the same geographic regions of Brazil as FS. A specific and sensitive desmoglein-1 ELISA detected antibodies in 34 of 41 onchocerciasis (83%), 38 of 88 leishmaniasis (43%), 18 of 31 Chagas disease (58%), 7 of 28 SA blastomycosis (25%), and 14 of 83 leprosy sera (17%). These sera recognized epitopes restricted to the EC5 domain. These findings identify several etiological factors for FS. It is hypothesized that a component of insect vector saliva, rather than the parasite itself may trigger an antibody response to EC-5. In persons with the known HLA susceptibility alleles and living in endemic areas, a response to the EC1-2 domains may subsequently develop by epitope spreading with associated clinical signs of FS.展开更多
文摘根据世界卫生组织从巴西国家控制规划获得的信息得知,美洲锥虫病(Chagao Disease)的传播基本上已消除。此重大成就乃是由于根据“南美国家行动”(Initiatine of the Southern ConeCountries)而采取控制措施的结果,预计将于1998年组织独立的考察组对阻断锥虫病媒介和输液传播的成果进行验收。巴西是美洲锥虫病的最大流行国,其患病数占锥虫总发病数的40％以上。 在1970年,最早锥虫流行地区占巴西国土的36％以上。
文摘Pemphigus foliaceus (PF) and the endemic form Fogo Selvagem(FS)are mediated by pathogenic antibodies to the EC1-2 domains of desmoglein-1. There is a preclinical phase with antibodies to only EC5. Based on geographic clustering of cases, FS is thought to have an, as yet unidentified, environmental trigger. In this study we have searched for anti-desmoglein-1 antibodies in sera from parasitic (leishmaniasis, Chagas, and onchocerciasis), and infectious diseases (leprosy and South American (SA) blastomycosis), which are prevalent in the same geographic regions of Brazil as FS. A specific and sensitive desmoglein-1 ELISA detected antibodies in 34 of 41 onchocerciasis (83%), 38 of 88 leishmaniasis (43%), 18 of 31 Chagas disease (58%), 7 of 28 SA blastomycosis (25%), and 14 of 83 leprosy sera (17%). These sera recognized epitopes restricted to the EC5 domain. These findings identify several etiological factors for FS. It is hypothesized that a component of insect vector saliva, rather than the parasite itself may trigger an antibody response to EC-5. In persons with the known HLA susceptibility alleles and living in endemic areas, a response to the EC1-2 domains may subsequently develop by epitope spreading with associated clinical signs of FS.
