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阿魏酸芥子酸清除亚硝基自由基的动力学研究 被引量:4
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作者 张周恩 姚思德 +2 位作者 王文锋 林维真 林念芸 《环境科学学报》 CAS CSSCI CSCD 北大核心 1998年第4期396-400,共5页
利用脉冲辐解方法,研究了阿魏酸、芥子酸(HCA)快速清除NO·2的机理,测得NO·2从HCA抽氢反应的动力学常数为(72—74)×108dm3·mol-1·s-1量级,并发现在弱酸性条件下HC... 利用脉冲辐解方法,研究了阿魏酸、芥子酸(HCA)快速清除NO·2的机理,测得NO·2从HCA抽氢反应的动力学常数为(72—74)×108dm3·mol-1·s-1量级,并发现在弱酸性条件下HCA也能有效清除HNO2. 展开更多
关键词 亚硝基自由基 脉冲辐解 羟基肉酸 二氧化氮
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Stability, cytotoxicity, and saturation effect of the free radical-scavenging cinnamic acid-dopamine hybrid antioxidants 被引量:2
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作者 尹粉粉 吴争荣 +2 位作者 郑丽芳 李红玉 陈蓓宁 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2015年第3期148-155,共8页
Hybrid antioxidants cinnamoyldopamine(2a), p-coumaroyldopamine(2b), caffeoyldopamine(2c), feruloyldopamine(2d) and sinapoyldopamine(2e) were synthesized by conjugation of dopamine(DA) and hydroxycinnamic a... Hybrid antioxidants cinnamoyldopamine(2a), p-coumaroyldopamine(2b), caffeoyldopamine(2c), feruloyldopamine(2d) and sinapoyldopamine(2e) were synthesized by conjugation of dopamine(DA) and hydroxycinnamic acids(HCAs). The stabilities were studied in buffers at p H 1.3, p H 5.0, and p H 7.4 including the human plasma. All the compounds were found highly stable at acidic p H, but underwent hydrolysis at neutral p H. Furthermore, the hydrolysis proceeded much faster in plasma in the following order as indicated by half-life values(t1/2), 2c(1.21 h)〈2e(1.52 h)〈2d(1.85 h)〈2b(3.38 h)〈2a(3.88 h), correlating with the number of electron-donating groups. It has been proven by UV spectrum that 2c, 2d, and 2e displayed red shift of more than 50 nm as compared to 2a and 2b, because of the presence of OH and OCH3 groups. In addition, the compounds(2b–e) showed no cytotoxicity on normal HUVEC cells as DA, although 2a displayed a 16% inhibition of proliferation at 40 μM following 48 h incubation. Their free radical-scavenging activities were evaluated using ABTS^*+ and superoxide anion assays and the mechanisms were proposed. It was found that they all exhibited higher activities than trolox, a recognized antioxidant. Amazingly, in the case of the hybrids(2a–e), their activity was higher than that of HCAs while lower or comparable to that of DA, suggesting that there may be a "saturation effect" with the hybrid molecules in the antioxidant activities. 展开更多
关键词 DOPAMINE Hydroxycinnamic acid Free radical-scavenging activity CYTOTOXICITY STABILITY
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